Search Results - "Mortari, Márcia R."

Oral delivery of fish oil in oil-in-water nanoemulsion: development, colloidal stability and modulatory effect on in vivo inflammatory induction in mice by Santos, Débora S., Morais, José Athayde V., Vanderlei, Ísis A.C., Santos, Alexandre S., Azevedo, Ricardo B., Muehlmann, Luís A., Júnior, Osmindo R.P., Mortari, Márcia R., da Silva, Jaqueline R., da Silva, Sebastião W., Longo, João P.F.

“…We designed a dietary supplement strategy based on a nanoemulsified formulation of fish oil that was able to improve the absorption of hydrophobic fish oil in…”
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Alzheimer’s Disease: Innovative Therapeutic Approaches Based on Peptides and Nanoparticles by Mota, Isabela F. L., de Lima, Larissa S., Santana, Bruna de M., Gobbo, Giovanna de A. M., Bicca, João V. M. L., Azevedo, Juliana R. M., Veras, Letícia G., Taveira, Rodrigo de A. A., Pinheiro, Gabriela B., Mortari, Márcia R.

“…Alzheimer’s disease (AD) is the main cause of dementia in the world and its etiology is not yet fully understood. The pathology of AD is primarily…”
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Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom by Galante, Priscilla, Campos, Gabriel A. A., Moser, Jacqueline C. G., Martins, Danubia B., dos Santos Cabrera, Marcia P., Rangel, Marisa, Coelho, Luiza C., Simon, Karina S., Amado, Veronica M., de A. I. Muller, Jessica, Koehbach, Johannes, Lohman, Rink-Jan, Cabot, Peter J., Vetter, Irina, Craik, David J., Toffoli-Kadri, Monica C., Monge-Fuentes, Victoria, Goulart, Jair T., Schwartz, Elisabeth F., Silva, Luciano P., Bocca, Anamelia L., Mortari, Márcia R.

“…Animal venoms are rich sources of neuroactive compounds, including anti-inflammatory, antiepileptic, and antinociceptive molecules. Our study identified a…”
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New insights in the mode of action of (+)-erythravine and (+)-11α-hydroxy-erythravine alkaloids by Gelfuso, Erica A., Reis, Suelen L., Aguiar, Daiane S.R., Faggion, Silmara A., Gomes, Flávia M.M., Galan, Diogo T., Peigneur, Steve, Pereira, Ana M.S., Mortari, Márcia R., Cunha, Alexandra O.S., Tytgat, Jan, Beleboni, Renê O.

“…Erythrinian alkaloids ((+)-erythravine and (+)-11-α-hydroxy-erythravine) have been pointed as the main responsible agents for the anticonvulsant and anxiolytic…”
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Antimicrobial and Chemotactic Activity of Scorpion-Derived Peptide, ToAP2, against Mycobacterium massiliensis by Marques-Neto, Lázaro M, Trentini, Monalisa M, das Neves, Rogério C, Resende, Danilo P, Procopio, Victor O, da Costa, Adeliane C, Kipnis, André, Mortari, Márcia R, Schwartz, Elisabeth F, Junqueira-Kipnis, Ana Paula

“…is a rapid growing, multidrug-resistant, non-tuberculous mycobacteria that is responsible for a wide spectrum of skin and soft tissue infections, as well as…”
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Anxiolytic-like effect of a novel peptide isolated from the venom of the social wasp Synoeca surinama by Gomes, Flávia M.M., Paniago, Cássia K., Freire, Daniel O., Souza, Adolfo C.B., Lima, Marcos R., Oliveira-Júnior, Nelson G., Franco, Octavio L., Mortari, Márcia R.

“…Pathological anxiety is among the most common psychiatric illnesses, but current treatment is highly limited. In this study, we investigated the potential…”
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Venomic and pharmacological activity of Acanthoscurria paulensis (Theraphosidae) spider venom by Mourão, Caroline Barbosa F., Oliveira, Fagner Neves, e Carvalho, Andréa C., Arenas, Claudia J., Duque, Harry Morales, Gonçalves, Jacqueline C., Macêdo, Jéssica K.A., Galante, Priscilla, Schwartz, Carlos A., Mortari, Márcia R., Almeida Santos, Maria de Fátima M., Schwartz, Elisabeth F.

“…In the present study we conducted proteomic and pharmacological characterizations of the venom extracted from the Brazilian tarantula Acanthoscurria paulensis,…”
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Wasp venom peptide, synoeca‐MP, from Synoeca surinama shows antimicrobial activity against human and animal pathogenic microorganisms by Freire, Daniel O., da Cunha, Nicolau B., Leite, Michel L., Kostopoulos, Alessandra G. C., da Silva, Sheila N. B., Souza, Adolfo C. B., Nolasco, Diego O., Franco, Octávio L., Mortari, Márcia R., Dias, Simoni C.

“…The rising number of multidrug‐resistant microorganisms has triggered interest in the prospection of biocompounds with antimicrobial activities. Synoeca‐MP…”
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Acute and subchronic toxicity of the antitumor agent rhodium (II) citrate in Balb/c mice after intraperitoneal administration by Carneiro, Marcella L B, Lopes, Cláudio A P, Miranda-Vilela, Ana L, Joanitti, Graziella A, da Silva, Izabel C R, Mortari, Márcia R, de Souza, Aparecido R, Báo, Sônia N

“…This study aimed to investigate potential acute and subchronic toxicity of rhodium (II) citrate in female Balb/c mice after intraperitoneal injections. In the…”
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Animal venoms: therapeutic tools for tackling Parkinson’s disease by de Oliveira Amaral, Henrique, Monge-Fuentes, Victoria, Biolchi Mayer, Andréia, Alves Campos, Gabriel Avohay, Soares Lopes, Kamila, Camargo, Luana C., Ferroni Schwartz, Matheus, Galante, Priscilla, Mortari, Márcia R.

“…•Parkinson’s disease (PD) is the fastest growing neurological disorder, surpassing Alzheimer’s disease.•PD remains incurable and pharmacological treatment is…”
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Evaluation of the antimicrobial activity of the mastoparan Polybia-MPII isolated from venom of the social wasp Pseudopolybia vespiceps testacea (Vespidae, Hymenoptera) by Silva, Juliana Castro e, Neto, Lázaro Moreira Marques, Neves, Rogério Coutinho das, Gonçalves, Jaqueline Coimbra, Trentini, Monalisa Martins, Mucury-Filho, Ricardo, Smidt, Karina Simon, Fensterseifer, Isabel Cristina Marques, Silva, Osmar Nascimento, Lima, Lilian Daiene Mota, Clissa, Patricia Bianca, Vilela, Nathália, Guilhelmelli, Fernanda, Silva, Luciano Paulino, Rangel, Marisa, Kipnis, André, Silva-Pereira, Ildinete, Franco, Octavio Luiz, Junqueira-Kipnis, Ana Paula, Bocca, Anamelia Lorenzetti, Mortari, Márcia Renata

“…Highlights • Polybia-MPII demonstrated potent activity against Staphylococcus aureus. • Topical application of Polybia-MPII reduced the number of S. aureus in…”
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Label-free quantitative proteomics of rat hypothalamus under fever induced by LPS and PGE2 by Firmino, Marina, Weis, Simone N., Souza, Jaques M.F., Gomes, Bruna R.B., Mól, Alan R., Mortari, Márcia R., Souza, Gloria E.P., Coca, Guilherme C., Williams, Thomas C.R., Fontes, Wagner, Ricart, Carlos André O., de Sousa, Marcelo V., Veiga-Souza, Fabiane H.

“…Fever is a brain-mediated increase in body temperature mainly during inflammatory or infectious challenges. Although there is considerable data regarding the…”
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Activity of Scorpion Venom-Derived Antifungal Peptides against Planktonic Cells of Candida spp. and Cryptococcus neoformans and Candida albicans Biofilms by Guilhelmelli, Fernanda, Vilela, Nathália, Smidt, Karina S, de Oliveira, Marco A, da Cunha Morales Álvares, Alice, Rigonatto, Maria C L, da Silva Costa, Pedro H, Tavares, Aldo H, de Freitas, Sônia M, Nicola, André M, Franco, Octávio L, Derengowski, Lorena da Silveira, Schwartz, Elisabeth F, Mortari, Márcia R, Bocca, Anamélia L, Albuquerque, Patrícia, Silva-Pereira, Ildinete

“…The incidence of fungal infections has been increasing in the last decades, while the number of available antifungal classes remains the same. The natural and…”
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Ceftriaxone pretreatment confers neuroprotection in rats with acute glaucoma and reduces the score of seizures induced by pentylenotetrazole in mice by Fachim, Helene A., Guizzo, Renato, Cunha, Alexandra O. S., Pereira, Adriana C., Anjos, Lilian C., Mortari, Márcia R., Santos, Wagner F.

“…β‐Lactam antibiotics such as ceftriaxone, are potent stimulators of the expression of l‐glutamate transporter GLT‐1 and may exert neuroprotective effects when…”
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Arthropod venoms: A vast arsenal of insecticidal neuropeptides by Schwartz, Elisabeth F., Mourão, Caroline B. F., Moreira, Karla G., Camargos, Thalita S., Mortari, Márcia R.

“…Arthropods are the most diverse animal group on the planet, and occupy almost all ecological niches. Venomous arthropods are a rich source of bioactive…”
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Non-disulfide-Bridge Peptide 5.5 from the Scorpion Hadrurus gertschi Inhibits the Growth of Mycobacterium abscessus subsp. massiliense by Trentini, Monalisa M, das Neves, Rogério C, Santos, Bruno de Paula Oliveira, DaSilva, Roosevelt A, de Souza, Adolfo C Barros, Mortari, Márcia R, Schwartz, Elisabeth F, Kipnis, André, Junqueira-Kipnis, Ana P

“…Multi-drug resistant microorganisms have been a growing concern during the last decades due to their contribution in mortality rates worldwide. Antimicrobial…”
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Parawixin2, a novel non-selective GABA uptake inhibitor from Parawixia bistriata spider venom, inhibits pentylenetetrazole-induced chemical kindling in rats by Gelfuso, Erica A., Liberato, José L., Cunha, Alexandra O.S., Mortari, Márcia R., Beleboni, Renê O., Lopes, Norberto P., dos Santos, Wagner F.

“…•We investigated the effects of Parawixin2 in kindling acquisition.•We used sub-convulsive doses of PTZ until fully kindled animals were observed.•We compared…”
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Towards Therapeutic Applications of Arthropod Venom K^+-Channel Blockers in CNS Neurologic Diseases Involving Memory Acquisition and Storage by Gati, Christiano D. C., Mortari, Márcia R., Schwartz, Elisabeth F.

“…Potassium channels are the most heterogeneous and widely distributed group of ion channels and play important functions in all cells, in both normal and…”
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Neuropharmacological Effects in Mice of Lychnophora Species (Vernonieae, Asteraceae) and Anticonvulsant Activity of 4,5‐di‐O‐[E]‐caffeoylquinic Acid Isolated From the Stem of L. rupestris and L. staavioides by Taleb‐Contini, Silvia H., Santos, Wagner F., Mortari, Márcia R., Lopes, Norberto P., Lopes, João L. C.

“…:   Aiming at contributing with the search for neuroactive substances from natural sources, we report for the first time antinociceptive and anticonvulsant…”
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Antimicrobial and Anticancer Properties of Synthetic Peptides Derived from the Wasp Parachartergus fraternus by Muller, Jessica A. I., Lawrence, Nicole, Chan, Lai Yue, Harvey, Peta J., Elliott, Alysha G., Blaskovich, Mark A. T., Gonçalves, Jacqueline C., Galante, Priscilla, Mortari, Marcia R., Toffoli‐Kadri, Mônica C., Koehbach, Johannes, Craik, David J.

“…Agelaia‐MPI and protonectin are antimicrobial peptides isolated from the wasp Parachartergus fraternus that show antimicrobial and neuroactive activities…”
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