Search Results - "Mort, Richard L"

The melanocyte lineage in development and disease by Mort, Richard L, Jackson, Ian J, Patton, E Elizabeth

“…Melanocyte development provides an excellent model for studying more complex developmental processes. Melanocytes have an apparently simple aetiology,…”
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Hierarchical patterning modes orchestrate hair follicle morphogenesis by Glover, James D, Wells, Kirsty L, Matthäus, Franziska, Painter, Kevin J, Ho, William, Riddell, Jon, Johansson, Jeanette A, Ford, Matthew J, Jahoda, Colin A B, Klika, Vaclav, Mort, Richard L, Headon, Denis J

“…Two theories address the origin of repeating patterns, such as hair follicles, limb digits, and intestinal villi, during development. The Turing…”
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A Multi-stage Representation of Cell Proliferation as a Markov Process by Yates, Christian A., Ford, Matthew J., Mort, Richard L.

“…The stochastic simulation algorithm commonly known as Gillespie’s algorithm (originally derived for modelling well-mixed systems of chemical reactions) is now…”
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Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates by Riddell, Jon, Noureen, Shahzeb Raja, Sedda, Luigi, Glover, James D, Ho, William K. W, Bain, Connor A, Berbeglia, Arianna, Brown, Helen, Anderson, Calum, Chen, Yuhang, Crichton, Michael L, Yates, Christian A, Mort, Richard L, Headon, Denis J

“…Embryonic mesenchymal cells are dispersed within an extracellular matrix but can coalesce to form condensates with key developmental roles. Cells within…”
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Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model by Mort, Richard L., Ross, Robert J. H., Hainey, Kirsten J., Harrison, Olivia J., Keighren, Margaret A., Landini, Gabriel, Baker, Ruth E., Painter, Kevin J., Jackson, Ian J., Yates, Christian A.

“…Bands of colour extending laterally from the dorsal to ventral trunk are a common feature of mouse chimeras. These stripes were originally taken as evidence of…”
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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis by Lindsay, Colin R., Lawn, Samuel, Campbell, Andrew D., Faller, William J., Rambow, Florian, Mort, Richard L., Timpson, Paul, Li, Ang, Cammareri, Patrizia, Ridgway, Rachel A., Morton, Jennifer P., Doyle, Brendan, Hegarty, Shauna, Rafferty, Mairin, Murphy, Ian G., McDermott, Enda W., Sheahan, Kieran, Pedone, Katherine, Finn, Alexander J., Groben, Pamela A., Thomas, Nancy E., Hao, Honglin, Carson, Craig, Norman, Jim C., Machesky, Laura M., Gallagher, William M., Jackson, Ian J., Van Kempen, Leon, Beermann, Friedrich, Der, Channing, Larue, Lionel, Welch, Heidi C., Ozanne, Brad W., Sansom, Owen J.

“…Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the Western world. Molecular…”
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PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins by Hall, Emma A., Nahorski, Michael S., Murray, Lyndsay M., Shaheen, Ranad, Perkins, Emma, Dissanayake, Kosala N., Kristaryanto, Yosua, Jones, Ross A., Vogt, Julie, Rivagorda, Manon, Handley, Mark T., Mali, Girish R., Quidwai, Tooba, Soares, Dinesh C., Keighren, Margaret A., McKie, Lisa, Mort, Richard L., Gammoh, Noor, Garcia-Munoz, Amaya, Davey, Tracey, Vermeren, Matthieu, Walsh, Diana, Budd, Peter, Aligianis, Irene A., Faqeih, Eissa, Quigley, Alan J., Jackson, Ian J., Kulathu, Yogesh, Jackson, Mandy, Ribchester, Richard R., von Kriegsheim, Alex, Alkuraya, Fowzan S., Woods, C. Geoffrey, Maher, Eamonn R., Mill, Pleasantine

“…During neurotransmission, synaptic vesicles undergo multiple rounds of exo-endocytosis, involving recycling and/or degradation of synaptic proteins. While…”
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Rac1 Drives Melanoblast Organization during Mouse Development by Orchestrating Pseudopod- Driven Motility and Cell-Cycle Progression by Li, Ang, Ma, Yafeng, Yu, Xinzi, Mort, Richard L., Lindsay, Colin R., Stevenson, David, Strathdee, Douglas, Insall, Robert H., Chernoff, Jonathan, Snapper, Scott B., Jackson, Ian J., Larue, Lionel, Sansom, Owen J., Machesky, Laura M.

“…During embryogenesis, melanoblasts proliferate and migrate ventrally through the developing dermis and epidermis as single cells. Targeted deletion of Rac1 in…”
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Maintenance of distinct melanocyte populations in the interfollicular epidermis by Glover, James D., Knolle, Stefan, Wells, Kirsty L., Liu, Dianbo, Jackson, Ian J., Mort, Richard L., Headon, Denis J.

“…Summary Hair follicles and sweat glands are recognized as reservoirs of melanocyte stem cells (MSCs). Unlike differentiated melanocytes, undifferentiated MSCs…”
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Increased corneal epithelial turnover contributes to abnormal homeostasis in the Pax6(+/-) mouse model of aniridia by Douvaras, Panagiotis, Mort, Richard L, Edwards, Dominic, Ramaesh, Kanna, Dhillon, Baljean, Morley, Steven D, Hill, Robert E, West, John D

“…We aimed to test previous predictions that limbal epithelial stem cells (LESCs) are quantitatively deficient or qualitatively defective in Pax6(+/-) mice and…”
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Melanins as Sustainable Resources for Advanced Biotechnological Applications by Galeb, Hanaa A., Wilkinson, Emma L., Stowell, Alison F., Lin, Hungyen, Murphy, Samuel T., Martin‐Hirsch, Pierre L., Mort, Richard L., Taylor, Adam M., Hardy, John G.

“…Melanins are a class of biopolymers that are widespread in nature and have diverse origins, chemical compositions, and functions. Their chemical, electrical,…”
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Effects of aberrant Pax6 gene dosage on mouse corneal pathophysiology and corneal epithelial homeostasis by Mort, Richard L, Bentley, Adam J, Martin, Francis L, Collinson, J Martin, Douvaras, Panagiotis, Hill, Robert E, Morley, Steven D, Fullwood, Nigel J, West, John D

“…Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6⁺/⁻ heterozygotes suffer from aniridia and aniridia-related…”
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Computer simulation of neutral drift among limbal epithelial stem cells of mosaic mice by West, John D., Mort, Richard L., Hill, Robert E., Morley, Steven D., Collinson, J. Martin

“…The use of mice that are mosaic for reporter gene expression underlies many lineage-tracing studies in stem cell biology. For example, using mosaic LacZ…”
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Stem cells and corneal epithelial maintenance: insights from the mouse and other animal models by Mort, Richard L, Douvaras, Panagiotis, Morley, Steven D, Dorà, Natalie, Hill, Robert E, Collinson, J Martin, West, John D

“…Maintenance of the corneal epithelium is essential for vision and is a dynamic process incorporating constant cell production, movement and loss. Although…”
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The melanocyte lineage in development and disease by Mort, Richard L, Jackson, Ian J, Patton, E Elizabeth

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Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration by Aloia, Luigi, McKie, Mikel Alexander, Vernaz, Grégoire, Cordero-Espinoza, Lucía, Aleksieva, Niya, van den Ameele, Jelle, Antonica, Francesco, Font-Cunill, Berta, Raven, Alexander, Aiese Cigliano, Riccardo, Belenguer, German, Mort, Richard L., Brand, Andrea H., Zernicka-Goetz, Magdalena, Forbes, Stuart J., Miska, Eric A., Huch, Meritxell

“…Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangiocytes. We…”
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Activated Mutant NRasQ61K Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism by Li, Ang, Ma, Yafeng, Jin, Meng, Mason, Susan, Mort, Richard L., Blyth, Karen, Larue, Lionel, Sansom, Owen J., Machesky, Laura M.

“…Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor…”
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The invasion speed of cell migration models with realistic cell cycle time distributions by Gavagnin, Enrico, Ford, Matthew J., Mort, Richard L., Rogers, Tim, Yates, Christian A.

“…•Given the average cell-cycle time, the minimum invasion speed is obtained when the cell-cycle time is Dirac-delta distributed;•We find the range of…”
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A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice by Ford, Matthew J., Yeyati, Patricia L., Mali, Girish R., Keighren, Margaret A., Waddell, Scott H., Mjoseng, Heidi K., Douglas, Adam T., Hall, Emma A., Sakaue-Sawano, Asako, Miyawaki, Atsushi, Meehan, Richard R., Boulter, Luke, Jackson, Ian J., Mill, Pleasantine, Mort, Richard L.

“…The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM)…”
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Fingerprinting of skin cells by live cell Raman spectroscopy reveals melanoma cell heterogeneity and cell‐type‐specific responses to UVR by Wilkinson, Emma L., Ashton, Lorna, Kerns, Jemma G., Allinson, Sarah L., Mort, Richard L.

“…Raman spectroscopy is an emerging dermatological technique with the potential to discriminate biochemically between cell types in a label‐free and non‐invasive…”
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