Search Results - "Mort, John"

The role of aggrecan in normal and osteoarthritic cartilage by Roughley, Peter J, Mort, John S

“…Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand…”
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Cole-Carpenter Syndrome Is Caused by a Heterozygous Missense Mutation in P4HB by Rauch, Frank, Fahiminiya, Somayyeh, Majewski, Jacek, Carrot-Zhang, Jian, Boudko, Sergei, Glorieux, Francis, Mort, John S., Bächinger, Hans-Peter, Moffatt, Pierre

“…Cole-Carpenter syndrome is a severe bone fragility disorder that is characterized by frequent fractures, craniosynostosis, ocular proptosis, hydrocephalus, and…”
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Recessive Osteogenesis Imperfecta Caused by Missense Mutations in SPARC by Mendoza-Londono, Roberto, Fahiminiya, Somayyeh, Majewski, Jacek, Tétreault, Martine, Nadaf, Javad, Kannu, Peter, Sochett, Etienne, Howard, Andrew, Stimec, Jennifer, Dupuis, Lucie, Roschger, Paul, Klaushofer, Klaus, Palomo, Telma, Ouellet, Jean, Al-Jallad, Hadil, Mort, John S., Moffatt, Pierre, Boudko, Sergei, Bächinger, Hans-Peter, Rauch, Frank

“…Secreted protein, acidic, cysteine-rich (SPARC) is a glycoprotein that binds to collagen type I and other proteins in the extracellular matrix. Using…”
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Mutations in WNT1 are a cause of osteogenesis imperfecta by Fahiminiya, Somayyeh, Majewski, Jacek, Mort, John, Moffatt, Pierre, Glorieux, Francis H, Rauch, Frank

“…Osteogenesis imperfecta (OI) is a heritable bone fragility disorder that is usually due to dominant mutations in COL1A1 or COL1A2. Rare recessive forms of OI,…”
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Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage by Dejica, Valeria M, Mort, John S, Laverty, Sheila, Antoniou, John, Zukor, David J, Tanzer, Michael, Poole, A Robin

“…The intra-helical cleavage of type II collagen by proteases, including collagenases and cathepsin K, is increased with aging and osteoarthritis (OA) in…”
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Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation by Boraschi-Diaz, Iris, Mort, John S., Brömme, Dieter, Senis, Yotis A., Mazharian, Alexandra, Komarova, Svetlana V.

“…The major organic component of bone is collagen type I. Osteoclasts are terminally differentiated multinucleated cells of hematopoietic origin that are…”
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Reduction in Disease Progression by Inhibition of Transforming Growth Factor α–CCL2 Signaling in Experimental Posttraumatic Osteoarthritis by Appleton, C. Thomas G., Usmani, Shirine E., Pest, Michael A., Pitelka, Vasek, Mort, John S., Beier, Frank

“…Objective Transforming growth factor α (TGFα) is increased in osteoarthritic (OA) cartilage in rats and humans and modifies chondrocyte phenotype. CCL2 is…”
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Reduction in Disease Progression by Inhibition of Transforming Growth Factor [alpha]-CCL2 Signaling in Experimental Posttraumatic Osteoarthritis by Appleton, C Thomas G, Usmani, Shirine E, Pest, Michael A, Pitelka, Vasek, Mort, John S, Beier, Frank

“…Objective Transforming growth factor [alpha] (TGF[alpha]) is increased in osteoarthritic (OA) cartilage in rats and humans and modifies chondrocyte phenotype…”
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MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein by Durigova, Michaela, Nagase, Hideaki, Mort, John S., Roughley, Peter J.

“…Aggrecan degradation in articular cartilage occurs predominantly through proteolysis and has been attributed to the action of members of the matrix…”
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Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis by Mort, John S, Geng, Yeqing, Fisher, William D, Roughley, Peter J

“…Aggrecan degradation is the hallmark of cartilage degeneration in osteoarthritis (OA), though it is unclear whether a common proteolytic process occurs in all…”
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Rho/ROCK and MEK/ERK activation by transforming growth factor-α induces articular cartilage degradation by Appleton, C Thomas G, Usmani, Shirine E, Mort, John S, Beier, Frank

“…Identification and characterization of therapeutic targets for joint conditions, such as osteoarthritis (OA), is exceedingly important for addressing the…”
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Structural basis for the recognition and cleavage of histone H3 by cathepsin L by Mort, John S, Min, Jinrong, Adams-Cioaba, Melanie A, Krupa, Joanne C, Xu, Chao

“…Proteolysis of eukaryotic histone tails has emerged as an important factor in the modulation of cell-cycle progression and cellular differentiation. The…”
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Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4 by Schelbergen, Rik F. P., Blom, Arjen B., van den Bosch, Martijn H. J., Slöetjes, Annet, Abdollahi-Roodsaz, Shahla, Schreurs, B. Wim, Mort, John S., Vogl, Thomas, Roth, Johannes, van den Berg, Wim B., van Lent, Peter L. E. M.

“…Objective S100A8 and S100A9 are two Ca2+ binding proteins classified as damage‐associated molecular patterns or alarmins that are found in high amounts in the…”
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Repeated Exposure to High‐Frequency Low‐Amplitude Vibration Induces Degeneration of Murine Intervertebral Discs and Knee Joints by McCann, Matthew R., Patel, Priya, Pest, Michael A., Ratneswaran, Anusha, Lalli, Gurkeet, Beaucage, Kim L., Backler, Garth B., Kamphuis, Meg P., Esmail, Ziana, Lee, Jimin, Barbalinardo, Michael, Mort, John S., Holdsworth, David W., Beier, Frank, Dixon, S. Jeffrey, Séguin, Cheryle A.

“…Objective High‐frequency, low‐amplitude whole‐body vibration (WBV) is being used to treat a range of musculoskeletal disorders; however, there is surprisingly…”
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A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis by Martin, Dianna C., Atmuri, Vasantha, Hemming, Richard J., Farley, Judith, Mort, John S., Byers, Sharon, Hombach-Klonisch, Sabine, Stern, Robert, Triggs-Raine, Barbara L.

“…Hyaluronidases are endoglycosidases that hydrolyze hyaluronan (HA), an abundant component of the extracellular matrix of vertebrate connective tissues. Six…”
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Glycosaminoglycan-Mediated Loss of Cathepsin K Collagenolytic Activity in MPS I Contributes to Osteoclast and Growth Plate Abnormalities by Wilson, Susan, Hashamiyan, Saadat, Clarke, Lorne, Saftig, Paul, Mort, John, Dejica, Valeria M, Brömme, Dieter

“…Mucopolysaccharidoses are a group of lysosomal storage diseases characterized by the build-up of glycosaminoglycans (GAGs) and severe skeletal abnormalities…”
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Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage by Dejica, Valeria M, Mort, John S, Laverty, Sheila, Percival, M. David, Antoniou, John, Zukor, David J, Poole, A. Robin

“…Cathepsin K is a cysteine protease of the papain family that cleaves triple-helical type II collagen, the major structural component of the extracellular…”
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The Pattern Recognition Receptor CD36 Is a Chondrocyte Hypertrophy Marker Associated with Suppression of Catabolic Responses and Promotion of Repair Responses to Inflammatory Stimuli by Cecil, Denise L, Appleton, C. Thomas G, Polewski, Monika D, Mort, John S, Schmidt, Ann Marie, Bendele, Alison, Beier, Frank, Terkeltaub, Robert

“…Multiple inflammatory mediators in osteoarthritis (OA) cartilage, including S100/calgranulin ligands of receptor for advanced glycation end products (RAGE),…”
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The structure and degradation of aggrecan in human intervertebral disc by Roughley, Peter J, Melching, Lee I, Heathfield, Terrence F, Pearce, Richard H, Mort, John S

“…The ability of the intervertebral disc to resist compression is dependent on its high proteoglycan concentration. The disc proteoglycans are classified as…”
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Efficient processing of procathepsin K to the mature form by Emmott, Alexander A., Mort, John S.

“…•Procathepsin K is well expressed in Pichia pastoris.•Processing to the mature active form has proven unpredictable.•Efficient autoprocessing occurs under…”
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