Search Results - "Morsink, Folkert H.M."

Pancreatic ductal adenocarcinoma in hereditary diffuse gastric cancer. A case report by Ottenhof, Niki A., MSc, de Wilde, Roeland F., MD, Morsink, Folkert H.M., BSc, de Leng, Wendy W.J., PhD, Ausems, Margreet G.E.M., MD, PhD, Morreau, Hans, MD, PhD, van Hillegersberg, Richard, MD, Offerhaus, G. Johan A., MD, PhD, Milne, Anya N., MD, PhD

“…Summary Hereditary diffuse gastric cancer is an autosomal dominant cancer syndrome characterized by highly penetrant diffuse gastric cancer. It is caused by…”
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Graft-versus-host-like disease complicating thymoma: Lack of AIRE expression as a cause of non-hereditary autoimmunity? by Offerhaus, G. Johan, Schipper, Marguerite E.I, Lazenby, Audrey J, Montgomery, Elizabeth, Morsink, Folkert H.M, Bende, Richard J, Musler, Alex R, van Lier, Rene A.W, van Noesel, Carel J.M

“…Abstract Three patients with graft-versus-host-like enterocolonopathy are reported. Their history was remarkable for thymoma and other autoimmune…”
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Well-differentiated Pancreatic Neuroendocrine Tumor in a Patient With Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM) by Noë, Michaël, Hackeng, Wenzel M, de Leng, Wendy W.J, Vergeer, Menno, Vleggaar, Frank P, Morsink, Folkert H.M, Wood, Laura D, Hruban, Ralph H, Offerhaus, G. Johan A, Brosens, Lodewijk A.A

“…Germline mutations in CDKN2A result in Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM), which is associated with an increased risk for pancreatic…”
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Stem cell dynamics and pretumor progression in the intestinal tract by Ma, Huiying, Morsink, Folkert H. M., Offerhaus, George Johan Arnold, de Leng, Wendy W. J.

“…Colorectal carcinogenesis is a process that follows a stepwise cascade that goes from the normal to an invisible pretumor stage ultimately leading to grossly…”
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Pancreatic intraepithelial neoplasia and pancreatic tumorigenesis: of mice and men by Ottenhof, Niki A, Milne, Anya N A, Morsink, Folkert H M, Drillenburg, Paul, Ten Kate, Fiebo J W, Maitra, Anirban, Offerhaus, G Johan

“…Pancreatic cancer has a poor prognosis with a 5-year survival of less than 5%. Early detection is at present the only way to improve this outlook. This review…”
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Monoclonal origin of primary unilateral multifocal pleomorphic adenoma of the parotid gland by van Egmond, Sylvia L., MD, de Leng, Wendy W.J., PhD, Morsink, Folkert H.M., BA, Offerhaus, G. Johan A., MD, PhD, MPH, Brosens, Lodewijk A.A., MD, PhD

“…Summary Primary multiple pleomorphic adenomas in a unilateral parotid gland in previously untreated patients is a rare finding, and little is known about the…”
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Mice lacking functional CD95-ligand display reduced proliferation of the intestinal epithelium without gross homeostatic alterations by Trumpi, Kari, Steller, Ernst J. A., de Leng, Wendy W., Raats, Daniëlle A., Nijman, Isaäc J., Morsink, Folkert H. M., Borel Rinkes, Inne H. M., Kranenburg, Onno

“…Homeostasis of the continuously self-renewing intestinal tract involves cell proliferation, migration, differentiation along the crypt-villus-axis and shedding…”
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Multiple Colorectal Neoplasms in X-Linked Agammaglobulinemia by Brosens, Lodewijk A.A, Tytgat, Kristien M.A.J, Morsink, Folkert H.M, Sinke, Richard J, Ten Berge, Ineke J.M, Giardiello, Francis M, Offerhaus, G. Johan A, Keller, Josbert J

“…X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disorder caused by germline mutation of the Bruton tyrosine kinase ( BTK ) gene. It is…”
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Organoid Models of Human and Mouse Ductal Pancreatic Cancer by Boj, Sylvia F., Hwang, Chang-Il, Baker, Lindsey A., Chio, Iok In Christine, Engle, Dannielle D., Corbo, Vincenzo, Jager, Myrthe, Ponz-Sarvise, Mariano, Tiriac, Hervé, Spector, Mona S., Gracanin, Ana, Oni, Tobiloba, Yu, Kenneth H., van Boxtel, Ruben, Huch, Meritxell, Rivera, Keith D., Wilson, John P., Feigin, Michael E., Öhlund, Daniel, Handly-Santana, Abram, Ardito-Abraham, Christine M., Ludwig, Michael, Elyada, Ela, Alagesan, Brinda, Biffi, Giulia, Yordanov, Georgi N., Delcuze, Bethany, Creighton, Brianna, Wright, Kevin, Park, Youngkyu, Morsink, Folkert H.M., Molenaar, I. Quintus, Borel Rinkes, Inne H., Cuppen, Edwin, Hao, Yuan, Jin, Ying, Nijman, Isaac J., Iacobuzio-Donahue, Christine, Leach, Steven D., Pappin, Darryl J., Hammell, Molly, Klimstra, David S., Basturk, Olca, Hruban, Ralph H., Offerhaus, George Johan, Vries, Robert G.J., Clevers, Hans, Tuveson, David A.

“…Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and…”
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Degree and site of chromosomal instability define its oncogenic potential by Hoevenaar, Wilma H. M., Janssen, Aniek, Quirindongo, Ajit I., Ma, Huiying, Klaasen, Sjoerd J., Teixeira, Antoinette, van Gerwen, Bastiaan, Lansu, Nico, Morsink, Folkert H. M., Offerhaus, G. Johan A., Medema, René H., Kops, Geert J. P. L., Jelluma, Nannette

“…Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy…”
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Diagnostic Utility of Menin Immunohistochemistry in Patients With Multiple Endocrine Neoplasia Type 1 Syndrome by Verschuur, Anna Vera D., Kok, Aranxa S.M., Morsink, Folkert H.M., de Leng, Wendy W.J., van den Broek, Medard F.M, Koudijs, Marco J., Offerhaus, Johan A., Valk, Gerlof D., Vriens, Menno R., van Nesselrooij, Bernadette P.M., Hackeng, Wenzel M., Brosens, Lodewijk A.A.

“…A clinical diagnosis of multiple endocrine neoplasia type 1 (MEN1) syndrome is usually confirmed with genetic testing in the germline. It is expected that…”
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Metastatic Patterns of Duodenopancreatic Neuroendocrine Tumors in Patients With Multiple Endocrine Neoplasia Type 1 by Hackeng, Wenzel M., van Beek, Dirk-Jan, Kok, Aranxa S.M., van Emst, Madelon, Morsink, Folkert H.M., van Treijen, Mark J.C., Borel Rinkes, Inne H.M., Dreijerink, Koen M.A., Offerhaus, G. Johan A., Valk, Gerlof D., Vriens, Menno R., Brosens, Lodewijk A.A.

“…Patients with multiple endocrine neoplasia 1 syndrome (MEN1) often develop multifocal duodenopancreatic neuroendocrine tumors (dpNETs). Nonfunctional…”
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High-Throughput Sequencing of Gastric Cancer Patients: Unravelling Genetic Predispositions Towards an Early-Onset Subtype by Machlowska, Julita, Kapusta, Przemysław, Baj, Jacek, Morsink, Folkert H. M., Wołkow, Paweł, Maciejewski, Ryszard, Offerhaus, G. Johan A., Sitarz, Robert

“…Background: Gastric cancer is the fourth most common cause of cancer-related death. Currently, it is broadly accepted that the molecular complexity and…”
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Genome Methylation Accurately Predicts Neuroendocrine Tumor Origin: An Online Tool by Hackeng, Wenzel M, Dreijerink, Koen M A, de Leng, Wendy W J, Morsink, Folkert H M, Valk, Gerlof D, Vriens, Menno R, Offerhaus, G Johan A, Geisenberger, Christoph, Brosens, Lodewijk A A

“…The primary origin of neuroendocrine tumor metastases can be difficult to determine by histopathology alone, but is critical for therapeutic decision making…”
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Diagnostic Utility of Menin Immunohistochemistry in Patients With Multiple Endocrine Neoplasia Type 1 Syndrome by Verschuur, Anna Vera D., Kok, Aranxa S.M., Morsink, Folkert H.M., de Leng, Wendy W.J., van den Broek, Medard F.M, Koudijs, Marco J., Offerhaus, Johan A., Valk, Gerlof D., Vriens, Menno R., van Nesselrooij, Bernadette P.M., Hackeng, Wenzel M., Brosens, Lodewijk A.A.

“…A clinical diagnosis of multiple endocrine neoplasia type 1 (MEN1) syndrome is usually confirmed with genetic testing in the germline. It is expected that…”
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Assessment of ARX expression, a novel biomarker for metastatic risk in pancreatic neuroendocrine tumors, in endoscopic ultrasound fine‐needle aspiration by Hackeng, Wenzel M., Morsink, Folkert H. M., Moons, Leon M. G., Heaphy, Christopher M., Offerhaus, G. Johan A., Dreijerink, Koen M. A., Brosens, Lodewijk A. A.

“…Background The transcription factors ARX and PDX1, and alternative lengthening of telomeres (ALT) were recently described as prognostic markers for resected…”
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Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review by Kryklyva, Valentyna, Haj Mohammad, Nadia, Morsink, Folkert H M, Ligtenberg, Marjolijn J L, Offerhaus, G Johan A, Nagtegaal, Iris D, de Leng, Wendy W J, Brosens, Lodewijk A A

“…Acinar cell carcinoma (ACC) is a rare pancreatic neoplasm with dismal prognosis. Insights into the molecular basis of ACC can pave the way for the application…”
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Metastatic Patterns of Duodenopancreatic Neuroendocrine Tumors in Patients With Multiple Endocrine Neoplasia Type 1 by Hackeng, Wenzel M., van Beek, Dirk-Jan, Kok, Aranxa S.M., van Emst, Madelon, Morsink, Folkert H.M., van Treijen, Mark J.C., Borel Rinkes, Inne H.M., Dreijerink, Koen M.A., Offerhaus, G. Johan A., Valk, Gerlof D., Vriens, Menno R., Brosens, Lodewijk A.A.

“…Patients with multiple endocrine neoplasia 1 syndrome (MEN1) often develop multifocal duodenopancreatic neuroendocrine tumors (dpNETs). Nonfunctional…”
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Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas by Hackeng, Wenzel M., Schelhaas, Willemien, Morsink, Folkert H. M., Heidsma, Charlotte M., van Eeden, Susanne, Valk, Gerlof D., Vriens, Menno R., Heaphy, Christopher M., Nieveen van Dijkum, Els J. M., Offerhaus, G. Johan A., Dreijerink, Koen M. A., Brosens, Lodewijk A. A.

“…Insulin-producing pancreatic neuroendocrine tumors (PanNETs)/insulinomas are generally considered to be indolent tumors with an excellent prognosis after…”
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Abstract 3570: Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer by Heerma van Voss, Marise R., Vesuna, Farhad, Trumpi, Kari, Brilliant, Justin, Kodach, Liudmila L., Morsink, Folkert H.M., Offerhaus, G. Johan A., Buerger, Horst, van der Wall, Elsken, van Diest, Paul J., Raman, Venu

“…Over 85% of colorectal cancers is driven by aberrations in the Wnt-signaling pathway. Thus, identifying druggable targets in this pathway can be beneficial for…”
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