Blood glucose and epicardial adipose tissue at the hospital admission as possible predictors for COVID-19 severity

Blood glucose and epicardial adipose tissue at the hospital admission as possible predictors for COVID-19 severity

Purpose To study the possible association of CT-derived quantitative epicardial adipose tissue (EAT) and glycemia at the admission, with severe outcomes in patients with COVID-19. Methods Two hundred and twenty-nine patients consecutively hospitalized for COVID-19 from March 1st to June 30th 2020 we...

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Bibliographic Details
Published in:Endocrine Vol. 75; no. 1; pp. 10 - 18
Main Authors: Guarisco, G., Fasolo, M., Capoccia, D., Morsello, G., Carraro, A., Zuccalà, P., Marocco, R., Del Borgo, C., Pelle, G., Iannarelli, A., Orlando, E., Spagnoli, A., Carbone, I., Lichtner, M., Iacobellis, G., Leonetti, F.
Format: Journal Article
Language:English
Published: New York Springer US 01-01-2022
Subjects:
Adipose Tissue - diagnostic imaging
Blood Glucose
COVID-19
Diabetes
Endocrinology
Hospital Mortality
Hospitals
Humanities and Social Sciences
Humans
Internal Medicine
Medicine
Medicine & Public Health
multidisciplinary
Original
Original Article
Pericardium - diagnostic imaging
SARS-CoV-2
Science
COVID-19
Visceral fat
Hyperglycemia
Adiposity
Epicardial adipose tissue
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Summary:Purpose To study the possible association of CT-derived quantitative epicardial adipose tissue (EAT) and glycemia at the admission, with severe outcomes in patients with COVID-19. Methods Two hundred and twenty-nine patients consecutively hospitalized for COVID-19 from March 1st to June 30th 2020 were studied. Non contrast chest CT scans, to confirm diagnosis of pneumonia, were performed. EAT volume (cm 3 ) and attenuation (Hounsfield units) were measured using a CT post-processing software. The primary outcome was acute respiratory distress syndrome (ARDS) or in-hospital death. Results The primary outcome occurred in 56.8% patients. Fasting blood glucose was significantly higher in the group ARDS/death than in the group with better prognosis [114 (98–144) vs. 101 (91–118) mg/dl, p  = 0.001]. EAT volume was higher in patients with vs without the primary outcome [103 (69.25; 129.75) vs. 78.95 (50.7; 100.25) cm 3 , p  < 0.001] and it was positively correlated with glycemia, PCR, fibrinogen, P / F ratio. In the multivariable logistic regression analysis, age and EAT volume were independently associated with ARDS/death. Glycemia and EAT attenuation would appear to be factors involved in ARDS/death with a trend of statistical significance. Conclusions Our findings suggest that both blood glucose and EAT, easily measurable and modifiable targets, could be important predisposing factors for severe Covid-19 complications.
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ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-021-02925-5