Search Results - "Mors Ole"

Inflammation in Depression and the Potential for Anti-Inflammatory Treatment by Kohler, Ole, Krogh, Jesper, Mors, Ole, Benros, Michael Eriksen

“…Accumulating evidence supports an association between depression and inflammatory processes, a connection that seems to be bidirectional. Clinical trials have…”
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A major role for common genetic variation in anxiety disorders by Purves, Kirstin L., Coleman, Jonathan R. I., Meier, Sandra M., Rayner, Christopher, Davis, Katrina A. S., Cheesman, Rosa, Bækvad-Hansen, Marie, Børglum, Anders D., Wan Cho, Shing, Jürgen Deckert, J., Gaspar, Héléna A., Bybjerg-Grauholm, Jonas, Hettema, John M., Hotopf, Matthew, Hougaard, David, Hübel, Christopher, Kan, Carol, McIntosh, Andrew M., Mors, Ole, Bo Mortensen, Preben, Nordentoft, Merete, Werge, Thomas, Nicodemus, Kristin K., Mattheisen, Manuel, Breen, Gerome, Eley, Thalia C.

“…Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30–60%. We conducted a genome-wide association study of Lifetime…”
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A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment by Schork, Andrew J., Won, Hyejung, Appadurai, Vivek, Nudel, Ron, Gandal, Mike, Delaneau, Olivier, Revsbech Christiansen, Malene, Hougaard, David M., Bækved-Hansen, Marie, Bybjerg-Grauholm, Jonas, Giørtz Pedersen, Marianne, Agerbo, Esben, Bøcker Pedersen, Carsten, Neale, Benjamin M., Daly, Mark J., Wray, Naomi R., Nordentoft, Merete, Mors, Ole, Børglum, Anders D., Bo Mortensen, Preben, Buil, Alfonso, Thompson, Wesley K., Geschwind, Daniel H., Werge, Thomas

“…There is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but the biological substrates mediating this overlap are not…”
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Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap by Gandal, Michael J, Haney, Jillian R, Parikshak, Neelroop N, Leppa, Virpi, Ramaswami, Gokul, Hartl, Chris, Schork, Andrew J, Appadurai, Vivek, Buil, Alfonso, Werge, Thomas M, Liu, Chunyu, White, Kevin P, Horvath, Steve, Geschwind, Daniel H

“…The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic…”
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A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders by Pedersen, Carsten Bøcker, Mors, Ole, Bertelsen, Aksel, Waltoft, Berit Lindum, Agerbo, Esben, McGrath, John J, Mortensen, Preben Bo, Eaton, William W

“…Understanding the epidemiologic profile of the life course of mental disorders is fundamental for research and planning for health care. Although previous…”
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Increased mortality among people with anxiety disorders: total population study by Meier, Sandra M., Mattheisen, Manuel, Mors, Ole, Mortensen, Preben B., Laursen, Thomas M., Penninx, Brenda W.

“…Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has…”
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Exploring Comorbidity Within Mental Disorders Among a Danish National Population by Plana-Ripoll, Oleguer, Pedersen, Carsten Bøcker, Holtz, Yan, Benros, Michael E, Dalsgaard, Søren, de Jonge, Peter, Fan, Chun Chieh, Degenhardt, Louisa, Ganna, Andrea, Greve, Aja Neergaard, Gunn, Jane, Iburg, Kim Moesgaard, Kessing, Lars Vedel, Lee, Brian K, Lim, Carmen C W, Mors, Ole, Nordentoft, Merete, Prior, Anders, Roest, Annelieke M, Saha, Sukanta, Schork, Andrew, Scott, James G, Scott, Kate M, Stedman, Terry, Sørensen, Holger J, Werge, Thomas, Whiteford, Harvey A, Laursen, Thomas Munk, Agerbo, Esben, Kessler, Ronald C, Mortensen, Preben Bo, McGrath, John J

“…Individuals with mental disorders often develop comorbidity over time. Past studies of comorbidity have often restricted analyses to a subset of disorders and…”
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Are depressive disorders caused by psychosocial stressors at work? A systematic review with metaanalysis by Mikkelsen, Sigurd, Coggon, David, Andersen, Johan Hviid, Casey, Patricia, Flachs, Esben Meulengracht, Kolstad, Henrik Albert, Mors, Ole, Bonde, Jens Peter

“…In the last decade, many studies have examined associations between poor psychosocial work environment and depression. We aimed to assess the evidence for a…”
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Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants by Satterstrom, F. Kyle, Walters, Raymond K., Singh, Tarjinder, Wigdor, Emilie M., Lescai, Francesco, Demontis, Ditte, Kosmicki, Jack A., Grove, Jakob, Stevens, Christine, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Palmer, Duncan S., Maller, Julian B., Nordentoft, Merete, Mors, Ole, Robinson, Elise B., Hougaard, David M., Werge, Thomas M., Bo Mortensen, Preben, Neale, Benjamin M., Børglum, Anders D., Daly, Mark J.

“…The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000…”
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FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses by Ahluwalia, Tarunveer S., Eliasen, Anders U., Sevelsted, Astrid, Pedersen, Casper-Emil T., Stokholm, Jakob, Chawes, Bo, Bork-Jensen, Jette, Grarup, Niels, Pedersen, Oluf, Hansen, Torben, Linneberg, Allan, Sharma, Amitabh, Weiss, Scott T., Evans, Michael D., Jackson, Daniel J., Morin, Andreanne, Krogfelt, Karen A., Schjørring, Susanne, Mortensen, Preben B., Hougaard, David M., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Mors, Ole, Nordentoft, Merete, Børglum, Anders D., Werge, Thomas, Agerbo, Esben, Gern, James E., Lemanske, Robert F., Ober, Carole, Pedersen, Anders G., Bisgaard, Hans, Bønnelykke, Klaus

“…Asthma with severe exacerbation is the most common cause of hospitalization among young children. We aim to increase the understanding of this clinically…”
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Experimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq by Rajkumar, Anto P, Qvist, Per, Lazarus, Ross, Lescai, Francesco, Ju, Jia, Nyegaard, Mette, Mors, Ole, Børglum, Anders D, Li, Qibin, Christensen, Jane H

“…Massively parallel cDNA sequencing (RNA-seq) experiments are gradually superseding microarrays in quantitative gene expression profiling. However, many…”
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Long-term trajectories of positive and negative symptoms in first episode psychosis: A 10year follow-up study in the OPUS cohort by Austin, Stephen F., Mors, Ole, Budtz-Jørgensen, Esben, Secher, Rikke Gry, Hjorthøj, Carsten R., Bertelsen, Mette, Jeppesen, Pia, Petersen, Lone, Thorup, Anne, Nordentoft, Merete

“…Knowledge about course of illness can help clinicians to develop effective interventions and improve treatment outcomes. The goal of this study was to…”
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The genetic architecture of sporadic and multiple consecutive miscarriage by Laisk, Triin, Soares, Ana Luiza G., Ferreira, Teresa, Painter, Jodie N., Censin, Jenny C., Laber, Samantha, Bacelis, Jonas, Chen, Chia-Yen, Lepamets, Maarja, Lin, Kuang, Liu, Siyang, Millwood, Iona Y., Ramu, Avinash, Southcombe, Jennifer, Andersen, Marianne S., Yang, Ling, Becker, Christian M., Børglum, Anders D., Gordon, Scott D., Bybjerg-Grauholm, Jonas, Helgeland, Øyvind, Hougaard, David M., Jin, Xin, Johansson, Stefan, Juodakis, Julius, Kartsonaki, Christiana, Kukushkina, Viktorija, Lind, Penelope A., Metspalu, Andres, Montgomery, Grant W., Morris, Andrew P., Mors, Ole, Mortensen, Preben B., Njølstad, Pål R., Nordentoft, Merete, Nyholt, Dale R., Lippincott, Margaret, Seminara, Stephanie, Salumets, Andres, Snieder, Harold, Zondervan, Krina, Werge, Thomas, Chen, Zhengming, Conrad, Donald F., Jacobsson, Bo, Li, Liming, Martin, Nicholas G., Neale, Benjamin M., Nielsen, Rasmus, Walters, Robin G., Granne, Ingrid, Medland, Sarah E., Mägi, Reedik, Lawlor, Deborah A., Lindgren, Cecilia M.

“…Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association…”
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Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors by Krebs, Morten Dybdahl, Themudo, Gonçalo Espregueira, Benros, Michael Eriksen, Mors, Ole, Børglum, Anders D., Hougaard, David, Mortensen, Preben Bo, Nordentoft, Merete, Gandal, Michael J., Fan, Chun Chieh, Geschwind, Daniel H., Schork, Andrew J., Werge, Thomas, Thompson, Wesley K.

“…Schizophrenia is a heterogeneous disorder, exhibiting variability in presentation and outcomes that complicate treatment and recovery. To explore this…”
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Combining clinical variables to optimize prediction of antidepressant treatment outcomes by Iniesta, Raquel, Malki, Karim, Maier, Wolfgang, Rietschel, Marcella, Mors, Ole, Hauser, Joanna, Henigsberg, Neven, Dernovsek, Mojca Zvezdana, Souery, Daniel, Stahl, Daniel, Dobson, Richard, Aitchison, Katherine J, Farmer, Anne, Lewis, Cathryn M, McGuffin, Peter, Uher, Rudolf

“…Abstract The outcome of treatment with antidepressants varies markedly across people with the same diagnosis. A clinically significant prediction of outcomes…”
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Adverse reactions to antidepressants by Uher, Rudolf, Farmer, Anne, Henigsberg, Neven, Rietschel, Marcella, Mors, Ole, Maier, Wolfgang, Kozel, Dejan, Hauser, Joanna, Souery, Daniel, Placentino, Anna, Strohmaier, Jana, Perroud, Nader, Zobel, Astrid, Rajewska-Rager, Aleksandra, Dernovsek, Moica Z., Larsen, Erik Roj, Kalember, Petra, Giovannini, Caterina, Barreto, Mara, McGuffin, Peter, Aitchison, Katherine J.

“…Adverse drug reactions are important determinants of non-adherence to antidepressant treatment, but their assessment is complicated by overlap with depressive…”
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Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis by Wils, Regitze Sølling, MD, Gotfredsen, Ditte Resendal, MD, Hjorthøj, Carsten, MSci, PhD, Austin, Stephen F., MSci, PhD, Albert, Nikolai, MD, Secher, Rikke Gry, MSci, PhD, Thorup, Anne Amalie Elgaard, MD, PhD, Mors, Ole, MD, PhD, Nordentoft, Merete, MD, PhD, Dr. Med.Sci

“…Abstract Background Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of…”
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Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups by Mattheisen, Manuel, Grove, Jakob, Als, Thomas D., Martin, Joanna, Voloudakis, Georgios, Meier, Sandra, Demontis, Ditte, Bendl, Jaroslav, Walters, Raymond, Carey, Caitlin E., Rosengren, Anders, Strom, Nora I., Hauberg, Mads Engel, Zeng, Biao, Hoffman, Gabriel, Zhang, Wen, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Agerbo, Esben, Cormand, Bru, Nordentoft, Merete, Werge, Thomas, Mors, Ole, Hougaard, David M., Buxbaum, Joseph D., Faraone, Stephen V., Franke, Barbara, Dalsgaard, Søren, Mortensen, Preben B., Robinson, Elise B., Roussos, Panos, Neale, Benjamin M., Daly, Mark J., Børglum, Anders D.

“…Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable neurodevelopmental conditions, with considerable…”
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Common Genetic Variation and Antidepressant Efficacy in Major Depressive Disorder: A Meta-Analysis of Three Genome-Wide Pharmacogenetic Studies by Uher, Rudolf, Tansey, Katherine E., Henigsberg, Neven, Wolfgang, Maier, Mors, Ole, Hauser, Joanna, Placentino, Anna, Souery, Daniel, Farmer, Anne, Aitchison, Katherine J., Craig, Ian, Peter, McGuffin, Lewis, Cathryn M., Ising, Marcus, Lucae, Susanne, Binder, Elisabeth B., Kloiber, Stefan, Holsboer, Florian, Müller-Myhsok, Bertram, Ripke, Stephan, Hamilton, Steven P., Soundy, Jared, Laje, Gonzalo, McMahon, Francis J., Fava, Maurizio, Rush, A. John, Perlis, Roy H.

“…ObjectiveIndirect evidence suggests that common genetic variation contributes to individual differences in antidepressant efficacy among individuals with major…”
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Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum by Ganna, Andrea, Satterstrom, F. Kyle, Zekavat, Seyedeh M., Das, Indraniel, Kurki, Mitja I., Churchhouse, Claire, Alfoldi, Jessica, Martin, Alicia R., Havulinna, Aki S., Byrnes, Andrea, Thompson, Wesley K., Nielsen, Philip R., Karczewski, Konrad J., Saarentaus, Elmo, Rivas, Manuel A., Gupta, Namrata, Pietiläinen, Olli, Emdin, Connor A., Lescai, Francesco, Bybjerg-Grauholm, Jonas, Flannick, Jason, Mercader, Josep M., Udler, Miriam, Laakso, Markku, Salomaa, Veikko, Hultman, Christina, Ripatti, Samuli, Hämäläinen, Eija, Moilanen, Jukka S., Körkkö, Jarmo, Kuismin, Outi, Nordentoft, Merete, Hougaard, David M., Mors, Ole, Werge, Thomas, Mortensen, Preben Bo, MacArthur, Daniel, Daly, Mark J., Sullivan, Patrick F., Locke, Adam E., Palotie, Aarno, Børglum, Anders D., Kathiresan, Sekar, Neale, Benjamin M.

“…There is a limited understanding about the impact of rare protein-truncating variants across multiple phenotypes. We explore the impact of this class of…”
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