Search Results - "Morrow, Jon S."

The loss of βΙ spectrin alters synaptic size and composition in the ja/ja mouse by Stankewich, Michael C, Peters, Luanne L, Morrow, Jon S

“…Deletion or mutation of members of the spectrin gene family contributes to many neurologic and neuropsychiatric disorders. While each spectrinopathy may…”
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Age-dependent ataxia and neurodegeneration caused by an αII spectrin mutation with impaired regulation of its calpain sensitivity by Miazek, Arkadiusz, Zalas, Michał, Skrzymowska, Joanna, Bogin, Bryan A., Grzymajło, Krzysztof, Goszczynski, Tomasz M., Levine, Zachary A., Morrow, Jon S., Stankewich, Michael C.

“…The neuronal membrane-associated periodic spectrin skeleton (MPS) contributes to neuronal development, remodeling, and organization. Post-translational…”
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Publisher Correction: Age-dependent ataxia and neurodegeneration caused by an αII spectrin mutation with impaired regulation of its calpain sensitivity by Miazek, Arkadiusz, Zalas, Michał, Skrzymowska, Joanna, Bogin, Bryan A., Grzymajło, Krzysztof, Goszczynski, Tomasz M., Levine, Zachary A., Morrow, Jon S., Stankewich, Michael C.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney by Stankewich, Michael C, Moeckel, Gilbert W, Ji, Lan, Ardito, Thomas, Morrow, Jon S

“…The kidney displays specialized regions devoted to filtration, selective reabsorption, and electrolyte and metabolite trafficking. The polarized membrane…”
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Targeted deletion of βIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes by Stankewich, Michael C, Gwynn, Babette, Ardito, Thomas, Ji, Lan, Kim, Jung, Robledo, Raymond F, Lux, Samuel E, Peters, Luanne L, Morrow, Jon S

“…The spectrin membrane skeleton controls the disposition of selected membrane channels, receptors, and transporters. In the brain βIII spectrin binds directly…”
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Fatal case of cutaneous‐sparing orolaryngeal zoster in a renal transplant recipient by Helou, Elie, Grant, Matthew, Landry, Marie, Wu, Xinyu, Morrow, Jon S., Malinis, Maricar F.

“…Herpesvirus infections in solid organ transplant (SOT) recipients are a significant cause of morbidity and mortality. We report a case of herpes zoster (HZ) in…”
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Rad9 Phosphorylation Sites Couple Rad53 to the Saccharomyces cerevisiae DNA Damage Checkpoint by Schwartz, Marc F, Duong, Jimmy K, Sun, Zhaoxia, Morrow, Jon S, Pradhan, Deepti, Stern, David F

“…Rad9 is required for the MEC1/ TEL1-dependent activation of Saccharomyces cerevisiae DNA damage checkpoint pathways mediated by Rad53 and Chk1. DNA damage…”
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Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale by Morrow, Jon S., Gershkovich, Peter, Gibson, Joanna, Gilshannon, Margaret, Kowalski, Diane, Levi, Angelique W., Nguyen, Don X., Rimm, David L., Xu, Mina L., Sinard, John

“…US medical schools increasingly seek ways to reduce costs and improve productivity. One aspect of this effort has been the development of performance-based…”
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Finding Your CAR: The Road Ahead for Engineered T Cells by Chen, Po-Han, Raghunandan, Rianna, Morrow, Jon S, Katz, Samuel G

“…Adoptive cellular therapy using chimeric antigen receptors (CARs) has transformed immunotherapy by engineering T cells to target specific antigens on tumor…”
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CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression by Zhang, Meiling, Liu, Zongzhi Z, Aoshima, Keisuke, Cai, Wesley L, Sun, Hongyin, Xu, Tianrui, Zhang, Yangyi, An, Yongyan, Chen, Jocelyn F, Chan, Lok Hei, Aoshima, Asako, Lang, Sabine M, Tang, Zhenwei, Che, Xuanlin, Li, Yao, Rutter, Sara J, Bossuyt, Veerle, Chen, Xiang, Morrow, Jon S, Pusztai, Lajos, Rimm, David L, Yin, Mingzhu, Yan, Qin

“…Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies. Emerging evidence suggests that certain epigenetic and…”
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Disrupted Synaptic Development in the Hypoxic Newborn Brain by Curristin, Sheila M., Cao, Anjun, Stewart, William B., Zhang, Heping, Madri, Joseph A., Morrow, Jon S., Ment, Laura R.

“…Infants born prematurely risk significant life-long cognitive disability, representing a major pediatric health crisis. The neuropathology of this cohort is…”
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Cell organization, growth, and neural and cardiac development require αII-spectrin by Stankewich, Michael C, Cianci, Carol D, Stabach, Paul R, Ji, Lan, Nath, Anjali, Morrow, Jon S

“…Spectrin α2 (αII-spectrin) is a scaffolding protein encoded by the Spna2 gene and constitutively expressed in most tissues. Exon trapping of Spna2 in C57BL/6…”
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Outer hair cell function is normal in βV spectrin knockout mice by Stankewich, Michael C., Bai, Jun-Ping, Stabach, Paul R., Khan, Saaim, Tan, Winston J.T., Surguchev, Alexei, Song, Lei, Morrow, Jon S., Santos-Sacchi, Joseph, Navaratnam, Dhasakumar S.

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Training Pathology Residents to Practice 21st Century Medicine by Black-Schaffer, W. Stephen, Morrow, Jon S., Prystowsky, Michael B., Steinberg, Jacob J.

“…Scientific advances, open information access, and evolving health-care economics are disrupting extant models of health-care delivery. Physicians increasingly…”
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Na,K-ATPase Transport from Endoplasmic Reticulum to Golgi Requires the Golgi Spectrin--Ankyrin G119 Skeleton in Madin Darby Canine Kidney Cells by Devarajan, Prasad, Stabach, Paul R., De Matteis, Maria Antonietta, Morrow, Jon S.

“…Spectrin (β IΣ * ) and ankyrin (AnkG119) associate with Golgi membranes and the dynactin complex, but their role in vesicle trafficking remains uncertain. We…”
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A Case of Fulminant Right Heart Failure Owing to Tumoral Pulmonary Hypertension by Wang, Kedong, Verma, Anuj, Fish, Kaitlin E., Hu, Jiun-Ruey, Miller, P. Elliott, Morrow, Jon S., Singh, Inderjit, Young, Lawrence H.

“…Tumoral pulmonary hypertension is a rare cause of pulmonary hypertension. We report a patient who was thought to have idiopathic pulmonary arterial…”
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The structure of the ankyrin-binding site of β-spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties by Stabach, Paul R., Simonović, Ivana, Ranieri, Miranda A., Aboodi, Michael S., Steitz, Thomas A., Simonović, Miljan, Morrow, Jon S.

“…Spectrin and ankyrin participate in membrane organization, stability, signal transduction, and protein targeting; their interaction is critical for erythrocyte…”
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Dynamic Regulation of CD45 Lateral Mobility by the Spectrin-Ankyrin Cytoskeleton of T Cells by Cairo, Christopher W., Das, Raibatak, Albohy, Amgad, Baca, Quentin J., Pradhan, Deepti, Morrow, Jon S., Coombs, Daniel, Golan, David E.

“…The leukocyte common antigen, CD45, is a critical immune regulator whose activity is modulated by cytoskeletal interactions. Components of the spectrin-ankyrin…”
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Reactive protoplasmic and fibrous astrocytes contain high levels of calpain-cleaved alpha 2 spectrin by Kim, Jung H., Kwon, Soojung J., Stankewich, Michael C., Huh, Gi-Yeong, Glantz, Susan B., Morrow, Jon S.

“…Calpain, a family of calcium-dependent neutral proteases, plays important roles in neurophysiology and pathology through the proteolytic modification of…”
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Training Pathology Residents to Practice 21st Century Medicine: A Proposal by Black-Schaffer, W. Stephen, Morrow, Jon S., Prystowsky, Michael B., Steinberg, Jacob J.

“…Scientific advances, open information access, and evolving health-care economics are disrupting extant models of health-care delivery. Physicians increasingly…”
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