Search Results - "Morrow, John P."

Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction by Wan, Elaine, Yeap, Xin Yi, Dehn, Shirley, Terry, Rachael, Novak, Margaret, Zhang, Shuang, Iwata, Shinichi, Han, Xiaoqiang, Homma, Shunichi, Drosatos, Konstantinos, Lomasney, Jon, Engman, David M., Miller, Stephen D., Vaughan, Douglas E., Morrow, John P., Kishore, Raj, Thorp, Edward B.

“…RATIONALE:Efficient clearance of apoptotic cells (efferocytosis) is a prerequisite for inflammation resolution and tissue repair. After myocardial infarction,…”
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Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes by Joseph, Leroy C, Barca, Emanuele, Subramanyam, Prakash, Komrowski, Michael, Pajvani, Utpal, Colecraft, Henry M, Hirano, Michio, Morrow, John P

“…Obesity and high saturated fat intake increase the risk of heart failure and arrhythmias. The molecular mechanisms are poorly understood. We hypothesized that…”
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Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation by Choi, Jason C, Muchir, Antoine, Wu, Wei, Iwata, Shinichi, Homma, Shunichi, Morrow, John P, Worman, Howard J

“…Mutations in the lamin A/C gene (LMNA), which encodes A-type lamins, cause a diverse range of diseases collectively called laminopathies, the most common of…”
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Clinical and cardiac characteristics of COVID‐19 mortalities in a diverse New York City Cohort by Abrams, Mark P., Wan, Elaine Y., Waase, Marc P., Morrow, John P., Dizon, Jose M., Yarmohammadi, Hirad, Berman, Jeremy P., Rubin, Geoffrey A., Kushnir, Alexander, Poterucha, Timothy J., Elias, Pierre A., Rubin, David A., Ehlert, Frederick, Biviano, Angelo, Uriel, Nir, Garan, Hasan, Saluja, Deepak

“…Introduction Electrocardiographic characteristics in COVID‐19‐related mortality have not yet been reported, particularly in racial/ethnic minorities. Methods…”
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Clinical Overview of Obesity and Diabetes Mellitus as Risk Factors for Atrial Fibrillation and Sudden Cardiac Death by Homan, Edwin A, Reyes, Michael V, Hickey, Kathleen T, Morrow, John P

“…The epidemics of obesity and diabetes mellitus are associated with an increased incidence of both atrial fibrillation (AF), the most common sustained…”
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ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene by Chatzifrangkeskou, Maria, Le Dour, Caroline, Wu, Wei, Morrow, John P, Joseph, Leroy C, Beuvin, Maud, Sera, Fusako, Homma, Shunichi, Vignier, Nicolas, Mougenot, Nathalie, Bonne, Gisèle, Lipson, Kenneth E, Worman, Howard J, Muchir, Antoine

“…Cardiomyopathy caused by lamin A/C gene mutations (LMNA cardiomyopathy) is characterized by increased myocardial fibrosis, which impairs left ventricular…”
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Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia by Joseph, Leroy C., PhD, Subramanyam, Prakash, PhD, Radlicz, Christopher, BS, Trent, Chad M., PhD, Iyer, Vivek, MD, MSE, Colecraft, Henry M., PhD, Morrow, John P., MD, FHRS

“…Background Diabetes and obesity are associated with an increased risk of arrhythmia and sudden cardiac death. Abnormal lipid accumulation is observed in…”
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The mitochondrial calcium uniporter promotes arrhythmias caused by high-fat diet by Joseph, Leroy C., Reyes, Michael V., Homan, Edwin A., Gowen, Blake, Avula, Uma Mahesh R., Goulbourne, Chris N., Wan, Elaine Y., Elrod, John W., Morrow, John P.

“…Obesity and diabetes increase the risk of arrhythmia and sudden cardiac death. However, the molecular mechanisms of arrhythmia caused by metabolic…”
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Admission Cardiac Diagnostic Testing with Electrocardiography and Troponin Measurement Prognosticates Increased 30-Day Mortality in COVID-19 by Poterucha, Timothy J, Elias, Pierre, Jain, Sneha S, Sayer, Gabriel, Redfors, Bjorn, Burkhoff, Daniel, Rosenblum, Hannah, DeFilippis, Ersilia M, Gupta, Aakriti, Lawlor, Matthew, Madhavan, Mahesh V, Griffin, Jan, Raikhelkar, Jayant, Fried, Justin, Clerkin, Kevin J, Kim, Andrea, Perotte, Adler, Maurer, Mathew S, Saluja, Deepak, Dizon, José, Ehlert, Frederick A, Morrow, John P, Yarmohammadi, Hirad, Biviano, Angelo B, Garan, Hasan, Rabbani, LeRoy, Leon, Martin B, Schwartz, Allan, Uriel, Nir, Wan, Elaine Y

“…Background Cardiovascular involvement in coronavirus disease 2019 (COVID-19) is common and leads to worsened mortality. Diagnostic cardiovascular studies may…”
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Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function by Joseph, Leroy C, Kokkinaki, Dimitra, Valenti, Mesele-Christina, Kim, Grace J, Barca, Emanuele, Tomar, Dhanendra, Hoffman, Nicholas E, Subramanyam, Prakash, Colecraft, Henry M, Hirano, Michio, Ratner, Adam J, Madesh, Muniswamy, Drosatos, Konstantinos, Morrow, John P

“…Cardiomyopathy frequently complicates sepsis and is associated with increased mortality. Increased cardiac oxidative stress and mitochondrial dysfunction have…”
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Editorial: Arrhythmogenic Substrates in Diabetes and Obesity by Morrow, John P, Akar, Fadi G, Aromolaran, Ademuyiwa S

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Correction: Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes by Joseph, Leroy C, Barca, Emanuele, Subramanyam, Prakash, Komrowski, Michael, Pajvani, Utpal, Colecraft, Henry M, Hirano, Michio, Morrow, John P

“…[This corrects the article DOI: 10.1371/journal.pone.0145750.]…”
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Cardiac electrophysiology consultative experience at the epicenter of the COVID-19 pandemic in the United States by Berman, Jeremy P., Abrams, Mark P., Kushnir, Alexander, Rubin, Geoffrey A., Ehlert, Frederick, Biviano, Angelo, Morrow, John P., Dizon, Jose, Wan, Elaine Y., Yarmohammadi, Hirad, Waase, Marc P., Rubin, David A., Garan, Hasan, Saluja, Deepak

“…The COVID-19 pandemic has greatly altered the practice of cardiac electrophysiology around the world for the foreseeable future. Professional organizations…”
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Combined metabolomic and transcriptomic profiling approaches reveal the cardiac response to high-fat diet by Joseph, Leroy C., Shi, Jianting, Nguyen, Quynh N., Pensiero, Victoria, Goulbourne, Chris, Bauer, Robert C., Zhang, Hanrui, Morrow, John P.

“…The response of vital organs to different types of nutrition or diet is a fundamental question in physiology. We examined the cardiac response to 4 weeks of…”
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Mechanisms of Chronic Metabolic Stress in Arrhythmias by Gowen, Blake H., Reyes, Michael V., Joseph, Leroy C., Morrow, John P.

“…Cardiac arrhythmias are responsible for many cardiovascular disease-related deaths worldwide. While arrhythmia pathogenesis is complex, there is increasing…”
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Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac Repair by Zhang, Shuang, BS, Yeap, Xin-Yi, MS, DeBerge, Matthew, PhD, Naresh, Nivedita K., PhD, Wang, Kevin, BS, Jiang, Zhengxin, PhD, Wilcox, Jane E., MD, White, Steven M., MD, PhD, Morrow, John P., MD, Burridge, Paul W., PhD, Procissi, Daniel, PhD, Scott, Evan A., PhD, Frazier, William, PhD, Thorp, Edward B., PhD

“…Visual Abstract…”
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Novel approaches to examine the regulation of voltage-gated calcium channels in the heart by Morrow, John P, Marx, Steven O

“…The cardiac L-type Ca(2+) channel plays a key role in cardiac excitation-contraction coupling, action potential duration, and gene expression. Abnormalities in…”
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Wide Complex Tachycardia Observed During Pregnancy by Lavelle, Michael P, Morrow, John P, Reiffel, James A

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Activation of the BK (SLO1) Potassium Channel by Mallotoxin by Zakharov, Sergey I., Morrow, John P., Liu, Guoxia, Yang, Lin, Marx, Steven O.

“…Pharmacologic approaches to activate K+ channels represent an emerging strategy to regulate membrane excitability. Here we report the identification and…”
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Paracardial fat and vitamin A: a mechanism for regulating exercise performance by Joseph, Leroy C, Morrow, John P

“…Different fat depots have different physiologic functions. In a provocative study published in this issue of the JCI, Petrosino et al. investigate the role of…”
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