Search Results - "Morrow, J I"

Microneedle Arrays Allow Lower Microbial Penetration Than Hypodermic Needles In Vitro by Donnelly, Ryan F., Singh, Thakur Raghu Raj, Tunney, Michael M., Morrow, Desmond I. J., McCarron, Paul A., O’Mahony, Conor, Woolfson, A. David

“…Methods In this study we determined, for the first time, the ability of microorganisms to traverse microneedle-induced holes using two different in vitro…”
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Laser-Engineered Dissolving Microneedle Arrays for Transdermal Macromolecular Drug Delivery by Migalska, Katarzyna, Morrow, Desmond I. J., Garland, Martin J., Thakur, Raj, Woolfson, A. David, Donnelly, Ryan F.

“…ABSTRACT Purpose To assess the feasibility of transdermal macromolecule delivery using novel laser-engineered dissolving microneedles (MNs) prepared from…”
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Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution by Donnelly, Ryan F., Garland, Martin J., Morrow, Desmond I.J., Migalska, Katarzyna, Singh, Thakur Raghu Raj, Majithiya, Rita, Woolfson, A. David

“…In this study, we used optical coherence tomography (OCT) to extensively investigate, for the first time, the effect that microneedle (MN) geometry (MN height,…”
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Microneedle Pre-treatment of Human Skin Improves 5-Aminolevulininc Acid (ALA)- and 5-Aminolevulinic Acid Methyl Ester (MAL)-Induced PpIX Production for Topical Photodynamic Therapy Without Increase in Pain or Erythema by Mikolajewska, Patrycja, Donnelly, Ryan F., Garland, Martin J., Morrow, Desmond I. J., Singh, Thakur Raghu Raj, Iani, Vladimir, Moan, Johan, Juzeniene, Asta

“…ABSTRACT Purpose To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as…”
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Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register by Morrow, J I, Hunt, S J, Russell, A J, Smithson, W H, Parsons, L, Robertson, I, Waddell, R, Irwin, B, Morrison, P J, Craig, J J

“…Objective: In the general population, folic acid supplementation during pregnancy has been demonstrated to reduce the frequency of neural tube defects (NTDs)…”
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Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: Potential for enhanced topical photodynamic therapy by Donnelly, Ryan F., Morrow, Desmond I.J., McCarron, Paul A., Woolfson, A. David, Morrissey, Anthony, Juzenas, Petras, Juzeniene, Asta, Iani, Vladimir, McCarthy, Helen O., Moan, Johan

“…Photodynamic therapy of deep or nodular skin tumours is currently limited by the poor tissue penetration of the porphyrin precursor 5-aminolevulinic acid…”
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Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding Technique by Donnelly, Ryan F., Majithiya, Rita, Singh, Thakur Raghu Raj, Morrow, Desmond I. J., Garland, Martin J., Demir, Yusuf K., Migalska, Katarzyna, Ryan, Elizabeth, Gillen, David, Scott, Christopher J., Woolfson, A. David

“…ABSTRACT Purpose Design and evaluation of a novel laser-based method for micromoulding of microneedle arrays from polymeric materials under ambient conditions…”
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Laser-Engineered Dissolving Microneedle Arrays for Transdermal Macromolecular Drug Delivery by MIGALSKA, Katarzyna, MORROW, Desmond I. J, GARLAND, Martin J, THAKUR, Raj, WOOLFSON, A. David, DONNELLY, Ryan F

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Processing difficulties and instability of carbohydrate microneedle arrays by Donnelly, Ryan F., Morrow, Desmond I.J., Singh, Thakur R.R., Migalska, Katarzyna, McCarron, Paul A., O'Mahony, Conor, Woolfson, A. David

“…Background: A number of reports have suggested that many of the problems currently associated with the use of microneedle (MN) arrays for transdermal drug…”
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Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: Assessments by transepidermal water loss by Gomaa, Yasmine A., Morrow, Desmond I.J., Garland, Martin J., Donnelly, Ryan F., El-Khordagui, Labiba K., Meidan, Victor M.

“…Microneedle (MN) arrays have attracted considerable attention in recent years due to their ability to facilitate effective transdermal drug delivery. Despite…”
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Microneedle Arrays Permit Enhanced Intradermal Delivery of a Preformed Photosensitizer by Donnelly, Ryan F., Morrow, Desmond I. J., McCarron, Paul A., David Woolfson, A., Morrissey, Anthony, Juzenas, Petras, Juzeniene, Asta, Iani, Vladimir, McCarthy, Helen O., Moan, Johan

“…Silicon microneedle (MN) arrays were used to puncture excised murine and porcine skin in vitro and transdermal and intradermal delivery of meso‐tetra…”
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Hexyl aminolaevulinate is a more effective topical photosensitiser precursor than methyl aminolaevulinate and 5-aminolaevulinic acids when applied in equimolar doses by Morrow, Desmond I J, McCarron, Paul A, Woolfson, A David, Juzenas, Petras, Juzeniene, Asta, Iani, Vladimir, Moan, Johan, Donnelly, Ryan F

“…Aminolaevulinic acid (ALA) is known to poorly penetrate into thick lesions, such as nodular basal cell carcinomas. Short chain ALA esters, possessing increased…”
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Anorexia nervosa remission following left thalamic stroke by Dusoir, H, Owens, C, Forbes, R B, Morrow, J I, Flynn, P A, McCarron, M O

“…Anorexia nervosa is an intense fear of weight gain, inaccurate perception of body size, weight or shape, amenorrhoea, and a body weight <85% of expected weight…”
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Adult survivors of severe cerebral hypoxia--case series survey and comparative analysis by Wilson, F C, Harpur, J, Watson, T, Morrow, J I

“…Over 16 years, Wilson [31] saw and assessed 567 patients, 18 (3.2%) had a primary diagnosis of cerebral hypoxia. The present patient survey includes all…”
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Vegetative state and minimally responsive patients--regional survey, long-term case outcomes and service recommendations by Wilson, F C, Harpur, J, Watson, T, Morrow, J I

“…A regional survey of Consultant level Neurology, Neurosurgical and Rehabilitation staff identified a retrospective estimate of patients in vegetative or…”
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In vitro phototoxicity of 5-aminolevulinic acid and its methyl ester and the influence of barrier properties on their release from a bioadhesive patch by Gilmore, Brendan F., McCarron, Paul A., Morrow, Desmond I.J., Murphy, Diarmaid J., Woolfson, A. David, Donnelly, Ryan F.

“…Topical administration of excess exogenous 5-aminolevulinic acid (ALA) leads to selective accumulation of the potent photosensitiser protoporphyrin IX (PpIX)…”
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Hydrogel-Forming and Dissolving Microneedles for Enhanced Delivery of Photosensitizers and Precursors by Donnelly, Ryan F., Morrow, Desmond I. J., McCrudden, Maelíosa T. C., Alkilani, Ahlam Zaid, Vicente-Pérez, Eva M., O'Mahony, Conor, González-Vázquez, Patricia, McCarron, Paul A., Woolfson, A. David

“…We present “one‐step application” dissolving and hydrogel‐forming microneedle arrays (MN) for enhanced delivery of photosensitizers/precursors. MN (280 μm)…”
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Acute respiratory failure in a middle aged woman by McGuigan, C, McDonnell, G, Mirakhur, M, Morrow, J I

“…A 61 year old woman presented with a one week history of headache, drowsiness, and shortness of breath. Initial examination revealed bilateral ptosis, which…”
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Primary isolated brainstem injury producing internuclear ophthalmoplegia by Gray, O. M., Forbes, R. B., Morrow, J. I.

“…Brainstem injuries are classically associated with a grave prognosis. We present a case of a male with primary isolated brainstem injury who had a right…”
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A neurological evaluation of adult phenylketonuria in Northern Ireland by McDonnell, G V, Esmonde, T F, Hadden, D R, Morrow, J I

“…To investigate the extent of neurological disease in adults with phenylketonuria and also their requirement for specialist medical services, we assessed 27…”
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