Search Results - "Morrissey, Richard E"

Phospholipidosis in Neurons Caused by Posaconazole, without Evidence for Functional Neurologic Effects by Cartwright, Mark E., Petruska, Janet, Arezzo, Joseph, Frank, Doyle, Litwak, Mona, Morrissey, Richard E., MacDonald, James, Davis, Thomas E.

“…The azole antifungal drug posaconazole caused phospholipidosis in neurons of the central nervous system, dorsal root ganglia of the spinal cord, and myenteric…”
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Rodent nonclinical safety evaluation studies of SCH 58500, an adenoviral vector for the p53 gene by MORRISSEY, Richard E, HORVATH, Christopher, SNYDER, Eileen A, PATRICK, James, MACDONALD, James S

“…SCH 58500 is a replication-defective recombinant adenoviral vector containing the cloned human wild-type (normal) tumor suppressor gene p53. SCH 58500 is in…”
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Ziracin-Induced Congenital Urogenital Malformations in Female Rats by Poulet, Frederique M., Veneziale, Robert, Vancutsem, Paul M., Losco, Patricia, Treinen, Kimberley, Morrissey, Richard E.

“…Spontaneous hypospadias is seldom observed in rats in contrast to its occurrence in 1 out of 250 human births. Ziracin, an antibacterial of the everninomycin…”
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Porcine toxicology studies of SCH 58500, an adenoviral vector for the p53 gene by MORRISSEY, Richard E, HORVATH, Christopher, SNYDER, Eileen A, PATRICK, James, COLLINS, Nathaniel, EVANS, Ellen, MACDONALD, James S

“…Adenoviral vectors are being actively investigated for their potential utility in gene therapy. SCH 58500, a replication-deficient adenoviral vector, carries…”
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Effects of perinatal loratadine exposure on male rat reproductive organ development by McIntyre, Barry S, Vancutsem, Paul M, Treinen, Kimberley A, Morrissey, Richard E

“…Normal pre- and postnatal male reproductive development and function is dependent upon testicular androgen production and is sensitive to antiandrogenic…”
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Studies by the National Toxicology Program on di(2-ethylhexyl)phthalate by Melnick, R L, Morrissey, R E, Tomaszewski, K E

“…In a 2-year feed study previously reported by the National Toxicology Program (NTP), the plasticizer di(2-ethylhexyl)phthalate (DEHP) was found to produce…”
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Developmental neurotoxicity evaluation of acrylamide in Sprague-Dawley rats by Wise, L.David, Gordon, Lea R., Soper, Keith A., Duchai, Donald M., Morrissey, Richard E.

“…Based on the literature to-date, the potential of acrylamide (ACRL) to cause developmental neurotoxicity in laboratory animals has not been assessed. We…”
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Retinoic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin selectively enhance teratogenesis in C57BL/6N mice by Birnbaum, L S, Harris, M W, Stocking, L M, Clark, A M, Morrissey, R E

“…TCDD is one of the most toxic man-made compounds and an extremely potent teratogen in mice. Many of its toxic symptoms resemble those seen during vitamin A…”
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Overview of Reproductive and Developmental Toxicity Studies of 1,3-Butadiene in Rodents by Morrissey, Richard E., Schwetz, Bernard A., Hackett, Patricia L., Sikov, Melvin R., Hardin, Bryan D., McClanahan, Beatrice J., Decker, John R., Mast, Terryl J.

“…A series of studies to further evaluate the developmental and reproductive toxicity of inhaled 1,3-butadiene was sponsored by the National Toxicology Program…”
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Developmental stages of the CD (Sprague-Dawley) rat skeleton after maternal exposure to ethylene glycol by Marr, M C, Price, C J, Myers, C B, Morrissey, R E

“…Ethylene glycol (EG), a chemical which causes skeletal malformations in rats, was administered by gavage to sperm positive CD rats on gestational days (gd) 6…”
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Arsenic-induced exencephaly in the mouse and associated lesions occurring during neurulation by Morrissey, R E, Mottet, N K

“…Early tissue damage following a teratogenic dose of arsenic to the dam was studied in mice with the objective of detecting the primary lesion associated with…”
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Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats by Field, E A, Price, C J, Sleet, R B, George, J D, Marr, M C, Myers, C B, Schwetz, B A, Morrissey, R E

“…Diethyl phthalate (DEP) and dimethyl phthalate (DMP), phthalic acid ester (PAE) plasticizers, were evaluated for developmental toxicity because of reports in…”
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Pharmacological and toxicological effects of chronic porcine growth hormone administration in dogs by Prahalada, S, Stabinski, L G, Chen, H Y, Morrissey, R E, De Burlet, G, Holder, D, Patrick, D H, Peter, C P, van Zwieten, M J

“…The purpose of this study was to evaluate the pharmacological and toxicological effects of exogenous GH administration in normal adult dogs. Because porcine GH…”
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Limited PCB antagonism of TCDD-induced malformations in mice by Morrissey, R E, Harris, M W, Diliberto, J J, Birnbaum, L S

“…C57BL/6N mice used to model induction of cleft palate and kidney malformations in offspring following maternal treatment with TCDD, were dosed on gestation day…”
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Teratogenic effects of 2,3,7,8-tetrabromodibenzo-p-dioxin and three polybrominated dibenzofurans in C57BL/6N mice by Birnbaum, L S, Morrissey, R E, Harris, M W

“…Brominated flame retardants involved in many industrial uses contain polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs) as contaminants. The…”
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Toxicokinetic and mechanistic considerations in the interpretation of the rodent bioassay by MacDonald, J S, Lankas, G R, Morrissey, R E

“…When chemicals that are nongenotoxic in conventional assays produce increases in tumor incidence in rodents in chronic bioassays, the determination of the…”
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Toxicity of the mycotoxin, cyclopiazonic acid, to Sprague-Dawley rats by Morrissey, R E, Norred, W P, Cole, R J, Dorner, J

“…Groups of male Sprague-Dawley rats received po doses of cyclopiazonic acid (CPA) on four consecutive days at 0.0, 0.2, 2.0, 4.0, or 8.0 mg kg-1 days-1…”
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Toxicity and carcinogenicity studies of nalidixic acid in rodents by Morrissey, R E, Eustis, S, Haseman, J K, Huff, J, Bucher, J R

“…Toxicity and carcinogenicity studies of nalidixic acid, an antimicrobial agent used to treat bacterial infections of the urinary tract, were conducted in…”
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Effects of long-term feeding of ammoniated, aflatoxin-contaminated corn to Fischer 344 rats by Norred, W P, Morrissey, R E

“…The effectiveness of ammonia treatment in reducing the chronic toxicity of aflatoxin-contaminated corn was determined. Fischer 344 rats were fed semi-purified…”
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Effects of cyclopiazonic acid on the ultrastructure of rat liver by Hinton, D M, Morrissey, R E, Norred, W P, Cole, R J, Dorner, J

“…Groups of Sprague-Dawley rats were dosed per os for 4 consecutive days with 0.0, 0.2, 2.0 or 4.0 mg cyclopiazonic acid (CPA)/kg body weight/day, and killed on…”
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