Search Results - "Morrissey, James H."

Polyphosphate is a cofactor for the activation of factor XI by thrombin by Choi, Sharon H., Smith, Stephanie A., Morrissey, James H.

“…Factor XI deficiency is associated with a bleeding diathesis, but factor XII deficiency is not, indicating that, in normal hemostasis, factor XI must be…”
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Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4 by Semeraro, Fabrizio, Ammollo, Concetta T., Morrissey, James H., Dale, George L., Friese, Paul, Esmon, Naomi L., Esmon, Charles T.

“…The release of histones from dying cells is associated with microvascular thrombosis and, because histones activate platelets, this could represent a possible…”
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Bacterial polyphosphates interfere with the innate host defense to infection by Roewe, Julian, Stavrides, Georgios, Strueve, Marcel, Sharma, Arjun, Marini, Federico, Mann, Amrit, Smith, Stephanie A., Kaya, Ziya, Strobl, Birgit, Mueller, Mathias, Reinhardt, Christoph, Morrissey, James H., Bosmann, Markus

“…Polyphosphates are linear polymers and ubiquitous metabolites. Bacterial polyphosphates are long chains of hundreds of phosphate units. Here, we report that…”
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Polyphosphate enhances fibrin clot structure by Smith, Stephanie A., Morrissey, James H.

“…Polyphosphate, a linear polymer of inorganic phosphate, is present in platelet dense granules and is secreted on platelet activation. We recently reported that…”
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Genetic duplication of tissue factor reveals subfunctionalization in venous and arterial hemostasis by Grzegorski, Steven J, Zhao, Yakun, Richter, Catherine E, Ku, Chia-Jui, Lavik, Kari I, Paul, Divyani, Morrissey, James H, Shavit, Jordan A

“…Tissue factor (TF) is an evolutionarily conserved protein necessary for initiation of hemostasis. Zebrafish have two copies of the tissue factor gene (f3a and…”
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Inhibitors of Polyphosphate and Neutrophil Extracellular Traps by Vappala, Sreeparna, Smith, Stephanie A, Kizhakkedathu, Jayachandran N, Morrissey, James H

“…The contact pathway of blood clotting has received intense interest in recent years as studies have linked it to thrombosis, inflammation, and innate immunity…”
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Polyphosphate exerts differential effects on blood clotting, depending on polymer size by Smith, Stephanie A., Choi, Sharon H., Davis-Harrison, Rebecca, Huyck, Jillian, Boettcher, John, Rienstra, Chad M., Morrissey, James H.

“…Polyphosphate, a linear polymer of inorganic phosphate, is secreted by activated platelets and accumulates in many infectious microorganisms. We recently…”
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Polyphosphate and RNA Differentially Modulate the Contact Pathway of Blood Clotting by Gajsiewicz, Joshua M., Smith, Stephanie A., Morrissey, James H.

“…The contact pathway of the plasma clotting cascade is dispensable for normal hemostasis, but contributes to thrombosis and serves as a bridge between…”
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Polyphosphate: a link between platelets, coagulation and inflammation by Morrissey, James H.

“…Inorganic polyphosphate (polyP) is abundant in biological organisms. PolyP is a major component of dense granules of human platelets and is secreted upon…”
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Factor XII inhibition reduces thrombus formation in a primate thrombosis model by Matafonov, Anton, Leung, Philberta Y., Gailani, Adam E., Grach, Stephanie L., Puy, Cristina, Cheng, Qiufang, Sun, Mao-fu, McCarty, Owen J.T., Tucker, Erik I., Kataoka, Hiroaki, Renné, Thomas, Morrissey, James H., Gruber, Andras, Gailani, David

“…The plasma zymogens factor XII (fXII) and factor XI (fXI) contribute to thrombosis in a variety of mouse models. These proteins serve a limited role in…”
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Polyphosphate, Zn2+ and high molecular weight kininogen modulate individual reactions of the contact pathway of blood clotting by Wang, Yuqi, Ivanov, Ivan, Smith, Stephanie A., Gailani, David, Morrissey, James H.

“…Background Inorganic polyphosphate modulates the contact pathway of blood clotting, which is implicated in thrombosis and inflammation. Polyphosphate polymer…”
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Polyphosphate in thrombosis, hemostasis, and inflammation by Baker, Catherine J., Smith, Stephanie A., Morrissey, James H.

“…This illustrated review focuses on polyphosphate as a potent modulator of the plasma clotting cascade, with possible roles in hemostasis, thrombosis, and…”
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Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis by Travers, Richard J., Shenoi, Rajesh A., Kalathottukaren, Manu Thomas, Kizhakkedathu, Jayachandran N., Morrissey, James H.

“…Polyphosphate (polyP) is secreted by activated platelets and has been shown to contribute to thrombosis, suggesting that it could be a novel antithrombotic…”
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Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design by La, Chanel C., Smith, Stephanie A., Vappala, Sreeparna, Adili, Reheman, Luke, Catherine E., Abbina, Srinivas, Luo, Haiming D., Chafeeva, Irina, Drayton, Matthew, Creagh, Louise A., de Guadalupe Jaraquemada-Peláez, Maria, Rhoads, Nicole, Kalathottukaren, Manu Thomas, Henke, Peter K., Straus, Suzana K., Du, Caigan, Conway, Edward M., Holinstat, Michael, Haynes, Charles A., Morrissey, James H., Kizhakkedathu, Jayachandran N.

“…Current treatments to prevent thrombosis, namely anticoagulants and platelets antagonists, remain complicated by the persistent risk of bleeding. Improved…”
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Diversification of polyphosphate end-labeling via bridging molecules by Baker, Catherine J, Smith, Stephanie A, Morrissey, James H

“…Investigation of the biological roles of inorganic polyphosphate has been facilitated by our previous development of a carbodiimide-based method for covalently…”
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Polyphosphate Modulates Blood Coagulation and Fibrinolysis by Smith, Stephanie A., Mutch, Nicola J., Baskar, Deepak, Rohloff, Peter, Docampo, Roberto, Morrissey, James H.

“…Inorganic polyphosphate is an abundant component of acidocalcisomes of bacteria and unicellular eukaryotes. Human platelet dense granules strongly resemble…”
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Size-Controlled Synthesis of Granular Polyphosphate Nanoparticles at Physiologic Salt Concentrations for Blood Clotting by Donovan, Alexander J, Kalkowski, Joseph, Smith, Stephanie A, Morrissey, James H, Liu, Ying

“…Size-controlled granular polyphosphate (PolyP) nanoparticles were synthesized by precipitation in aqueous solutions containing physiological concentrations of…”
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Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor by Wijeyewickrema, Lakshmi C., Lameignere, Emilie, Hor, Lilian, Duncan, Renee C., Shiba, Toshikazu, Travers, Richard J., Kapopara, Piyushkumar R., Lei, Victor, Smith, Stephanie A., Kim, Hugh, Morrissey, James H., Pike, Robert N., Conway, Edward M.

“…The complement system plays a key role in innate immunity, inflammation, and coagulation. The system is delicately balanced by negative regulatory mechanisms…”
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Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease by Hajeyah, Ali A, Protty, Majd B, Paul, Divyani, Costa, Daniela, Omidvar, Nader, Morgan, Bethan, Iwasaki, Yugo, McGill, Beth, Jenkins, P Vincent, Yousef, Zaheer, Allen-Redpath, Keith, Soyama, Shin, Choudhury, Anirban, Mitra, Rito, Yaqoob, Parveen, Morrissey, James H, Collins, Peter W, O'Donnell, Valerie B

“…Aminophospholipids (aPL) such as phosphatidylserine are essential for supporting the activity of coagulation factors, circulating platelets, and blood cells…”
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Tissue factor residues that putatively interact with membrane phospholipids by Ke, Ke, Yuan, Jian, Morrissey, James H

“…Blood clotting is initiated by the two-subunit enzyme consisting of the plasma protease, factor VIIa (the catalytic subunit), bound to the integral membrane…”
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