Search Results - "Morrison, J. H."

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease by GIANNAKOPOULOS, P, HERRMANN, F. R, BUSSIERE, T, BOURAS, C, KÖVARI, E, PERL, D. P, MORRISON, J. H, GOLD, G, HOF, P. R

“…To examine the relationship between stereologic estimates of AD-related pathology and severity of cognitive deficits in brain aging. Previous studies reported…”
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Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery by Goldwater, D.S, Pavlides, C, Hunter, R.G, Bloss, E.B, Hof, P.R, McEwen, B.S, Morrison, J.H

“…Abstract Chronic stress has been shown in animal models to result in altered dendritic morphology of pyramidal neurons of the medial prefrontal cortex (mPFC)…”
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Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex by Radley, J.J, Sisti, H.M, Hao, J, Rocher, A.B, McCall, T, Hof, P.R, McEwen, B.S, Morrison, J.H

“…Both the hippocampus and the medial prefrontal cortex (mPFC) play an important role in the negative feedback regulation of hypothalamic–pituitary–adrenal (HPA)…”
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Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey by Young, M.E, Ohm, D.T, Dumitriu, D, Rapp, P.R, Morrison, J.H

“…Highlights • Unlike neurons in dlPFC, neurons in V1 do not lose spines with age in rhesus monkeys. • Aging decreases the proportion of thin spines in macaque…”
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Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala by Johnson, L.R., Farb, C., Morrison, J.H., McEwen, B.S., Ledoux, J.E.

“…Glucocorticoids, released in high concentrations from the adrenal cortex during stressful experiences, bind to glucocorticoid receptors in nuclear and…”
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Life and Death of Neurons in the Aging Brain by Morrison, John H., Hof, Patrick R.

“…Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional…”
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Activity-regulated cytoskeletal-associated protein is localized to recently activated excitatory synapses by Moga, D.E., Calhoun, M.E., Chowdhury, A., Worley, P., Morrison, J.H., Shapiro, M.L.

“…Activity-regulated, cytoskeletal-associated protein (Arc) is an immediate early gene induced in excitatory circuits following behavioral episodes. Arc mRNA is…”
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The neurobiology of aging by Kelly, K.M., Nadon, N.L., Morrison, J.H., Thibault, O., Barnes, C.A., Blalock, E.M.

“…Basic principles of the neurobiology of aging were reviewed within selected topic areas chosen for their potential relevance to epileptogenesis in the aging…”
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Continuously delivered ovarian steroids do not alter dendritic spine density or morphology in macaque dorsolateral prefrontal cortical neurons by Young, M.E, Ohm, D.T, Janssen, W.G.M, Gee, N.A, Lasley, B.L, Morrison, J.H

“…Highlights • Continuous estradiol does not alter spine density or morphology in macaque dlPFC. • Adding cyclic progesterone to continuous estradiol does not…”
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α-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A– and NR2B–containing N -methyl- d -aspartate receptors in hippocampus by Park, C.S, Elgersma, Y, Grant, S.G.N, Morrison, J.H

“…Abstract N -methyl- d -aspartate receptors (NMDARs) are critical determinants of bidirectional synaptic plasticity, however, studies of NMDAR function have…”
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Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer’s disease by Bussire, T, Gold, G, Kvari, E, Giannakopoulos, P, Bouras, C, Perl, D.P, Morrison, J.H, Hof, P.R

“…Alzheimer’s disease (AD) is characterized neuropathologically by several features including extensive neuronal death in the cerebral cortex. In fact, while…”
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Estrogen and aging affect synaptic distribution of phosphorylated LIM kinase (pLIMK) in CA1 region of female rat hippocampus by Yildirim, M, Janssen, W.G.M, Tabori, N.E, Adams, M.M, Yuen, G.S, Akama, K.T, McEwen, B.S, Milner, T.A, Morrison, J.H

“…Abstract 17β-Estradiol (E) increases axospinous synapse density in the hippocampal CA1 region of young female rats, but not in aged rats. This may be linked to…”
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Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein by Grant, Seth G. N, Migaud, Martine, Charlesworth, Paul, Dempster, Maureen, Webster, Lorna C, Watabe, Ayako M, Makhinson, Michael, He, Yong, Ramsay, Mark F, Morris, Richard G. M, Morrison, John H, O'Dell, Thomas J

“…Specific patterns of neuronal firing induce changes in synaptic strength that may contribute to learning and memory. If the postsynaptic NMDA…”
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Quantitative analysis of the dendritic morphology of corticocortical projection neurons in the macaque monkey association cortex by Duan, H, Wearne, S.L, Morrison, J.H, Hof, P.R

“…The polymodal association areas of the primate cerebral cortex are heavily interconnected and play a crucial role in cognition. Area 46 of the prefrontal…”
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Different Modes of Hippocampal Plasticity in Response to Estrogen in Young and Aged Female Rats by Adams, Michelle M., Shah, Ravi A., William G. M. Janssen, Morrison, John H.

“…Estrogen regulates hippocampal dendritic spine density and synapse number in an N-methyl-D-aspartate (NMDA) receptor-dependent manner, and these effects may be…”
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Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer’s disease by Bussière, T., Friend, P.D., Sadeghi, N., Wicinski, B., Lin, G.I., Bouras, C., Giannakopoulos, P., Robakis, N.K., Morrison, J.H., Perl, D.P., Hof, P.R.

“…Although the presence of amyloid deposits is required to establish the neuropathologic diagnosis of Alzheimer’s disease, from a clinical point of view, a…”
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Regional, Cellular, and Ultrastructural Distribution of N-Methyl-D- Aspartate Receptor Subunit 1 in Monkey Hippocampus by Siegel, S. J., Brose, N., Janssen, W. G., Gasic, G. P., Jahn, R., Heinemann, S. F., Morrison, J. H.

“…The regional, cellular, and subcellular distributions of N-methyl-D-aspartate (NMDA) receptor subunit 1, NMDAR-1, were investigated in monkey hippocampus by…”
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Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders by BUEE, L, HOF, P. R, BOURAS, C, DELACOURTE, A, PERL, D. P, MORRISON, J. H, FILLIT, H. M

“…Alterations of the cerebral microvasculature have been reported in aging and in neurodegenerative disorders such as Alzheimer's disease. However, the exact…”
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Transgenic Mice Expressing an Altered Murine Superoxide Dismutase Gene Provide an Animal Model of Amyotrophic Lateral Sclerosis by Ripps, Michael E., Huntley, George W., Hof, Patrick R., Morrison, John H., Gordon, Jon W.

“…Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder primarily involving motoneurons. A subset of individuals with familial autosomal…”
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Circuit-Specific Alterations of N-Methyl-D-Aspartate Receptor Subunit 1 in the Dentate Gyrus of Aged Monkeys by Gazzaley, A. H., Siegel, S. J., Kordower, J. H., Mufson, E. J., Morrison, J. H.

“…Age-associated memory impairment occurs frequently in primates. Based on the established importance of both the perforant path and N-methyl-D-aspartate (NMDA)…”
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