Search Results - "Morrison, J. J."

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches by Ding, Lei, Morrison, Sean J.

“…A study of the physiological sources of the chemokine CXCL12 in mice shows that haematopoietic stem cells occupy a perivascular niche in the bone marrow…”
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SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors by Oguro, Hideyuki, Ding, Lei, Morrison, Sean J.

“…Hematopoietic stem cells (HSCs) and multipotent hematopoietic progenitors (MPPs) are routinely isolated using various markers but remain heterogeneous. Here we…”
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The bone marrow niche for haematopoietic stem cells by Morrison, Sean J., Scadden, David T.

“…Niches are local tissue microenvironments that maintain and regulate stem cells. Haematopoiesis provides a model for understanding mammalian stem cells and…”
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Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty by Magee, Jeffrey A., Piskounova, Elena, Morrison, Sean J.

“…The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers heterogeneity to some cancers beyond that explained by clonal…”
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Ultraviolet Photodissociation Mass Spectrometry for Analysis of Biological Molecules by Brodbelt, Jennifer S, Morrison, Lindsay J, Santos, Inês

“…The development of new ion-activation/dissociation methods continues to be one of the most active areas of mass spectrometry owing to the broad applications of…”
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Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow by Zhou, Bo O., Yue, Rui, Murphy, Malea M., Peyer, James G., Morrison, Sean J.

“…Studies of the identity and physiological function of mesenchymal stromal cells (MSCs) have been hampered by a lack of markers that permit both prospective…”
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Borderline ovarian tumours: balancing risks of recurrence over decades by Morrison, J

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Endothelial and perivascular cells maintain haematopoietic stem cells by Ding, Lei, Saunders, Thomas L., Enikolopov, Grigori, Morrison, Sean J.

“…Several cell types have been proposed to create niches for haematopoietic stem cells (HSCs). However, the expression patterns of HSC maintenance factors have…”
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The role of short chain fatty acids in appetite regulation and energy homeostasis by Byrne, C S, Chambers, E S, Morrison, D J, Frost, G

“…Over the last 20 years there has been an increasing interest in the influence of the gastrointestinal tract on appetite regulation. Much of the focus has been…”
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Chromatin-remodeling links metabolic signaling to gene expression by Morrison, Ashby J.

“…ATP-dependent chromatin remodelers are evolutionarily conserved complexes that alter nucleosome positioning to influence many DNA-templated processes, such as…”
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Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health by Chambers, Edward S., Preston, Tom, Frost, Gary, Morrison, Douglas J.

“…Purpose of this Review This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease…”
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Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution by Shackleton, Mark, Quintana, Elsa, Fearon, Eric R., Morrison, Sean J.

“…The identification and characterization of cancer stem cells might lead to more effective treatments for some cancers by focusing therapy on the most malignant…”
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Asymmetric and symmetric stem-cell divisions in development and cancer by Morrison, Sean J, Kimble, Judith

“…Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate…”
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Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms? by Chambers, Edward S., Morrison, Douglas J., Frost, Gary

“…In recent years, there has been a renewed interest in the role of dietary fibre in obesity management. Much of this interest stems from animal and human…”
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Will Ebola change the game? Ten essential reforms before the next pandemic. The report of the Harvard-LSHTM Independent Panel on the Global Response to Ebola by Moon, Suerie, Dr, Sridhar, Devi, Prof, Pate, Muhammad A, MD, Jha, Ashish K, Prof, Clinton, Chelsea, DPhil, Delaunay, Sophie, MA, Edwin, Valnora, MA, Fallah, Mosoka, PhD, Fidler, David P, Prof, Garrett, Laurie, PhD, Goosby, Eric, Prof, Gostin, Lawrence O, Prof, Heymann, David L, Prof, Lee, Kelley, Prof, Leung, Gabriel M, Prof, Morrison, J Stephen, PhD, Saavedra, Jorge, MD, Tanner, Marcel, Prof, Leigh, Jennifer A, MPH, Hawkins, Benjamin, PhD, Woskie, Liana R, MSc, Piot, Peter, Prof

“…The west African Ebola epidemic that began in 2013 exposed deep inadequacies in the national and international institutions responsible for protecting the…”
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Drugs Are Not Microchips: Whither Industrial Policy In The Life Sciences? by Morrison, J Stephen, Simoneau, Michaela

“…Events such as Russia's invasion of Ukraine in February 2022 have heightened global awareness of the potential for sudden market upheaval and the need for…”
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Lymph protects metastasizing melanoma cells from ferroptosis by Ubellacker, Jessalyn M., Tasdogan, Alpaslan, Ramesh, Vijayashree, Shen, Bo, Mitchell, Evann C., Martin-Sandoval, Misty S., Gu, Zhimin, McCormick, Michael L., Durham, Alison B., Spitz, Douglas R., Zhao, Zhiyu, Mathews, Thomas P., Morrison, Sean J.

“…Cancer cells, including melanoma cells, often metastasize regionally through the lymphatic system before metastasizing systemically through the blood 1 – 4 ;…”
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Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow by Comazzetto, Stefano, Murphy, Malea M., Berto, Stefano, Jeffery, Elise, Zhao, Zhiyu, Morrison, Sean J.

“…Hematopoietic stem cells (HSCs) are maintained in a perivascular niche in bone marrow, in which leptin receptor+ (LepR) stromal cells and endothelial cells…”
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Genome maintenance functions of the INO80 chromatin remodeller by Morrison, Ashby J.

“…Chromatin modification is conserved in all eukaryotes and is required to facilitate and regulate DNA-templated processes. For example, chromatin manipulation,…”
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Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF by Zhou, Bo O., Yu, Hua, Yue, Rui, Zhao, Zhiyu, Rios, Jonathan J., Naveiras, Olaia, Morrison, Sean J.

“…Endothelial cells and leptin receptor + (LepR + ) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell…”
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