Search Results - "Morrison, Helena W"

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion by Morrison, Helena W, Filosa, Jessica A

“…Microglia cells continuously survey the healthy brain in a ramified morphology and, in response to injury, undergo progressive morphological and functional…”
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Discovering novel plasma biomarkers for ischemic stroke: Lipidomic and metabolomic analyses in an aged mouse model by Becktel, Danielle A., Frye, Jennifer B., Le, Elizabeth H., Whitman, Susan A., Schnellmann, Rick G., Morrison, Helena W., Doyle, Kristian P.

“…Ischemic stroke remains a leading cause of mortality and long-term disability worldwide, necessitating efforts to identify biomarkers for diagnosis, prognosis,…”
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Can quantifying morphology and TMEM119 expression distinguish between microglia and infiltrating macrophages after ischemic stroke and reperfusion in male and female mice? by Young, Kimberly F, Gardner, Rebeca, Sariana, Victoria, Whitman, Susan A, Bartlett, Mitchell J, Falk, Torsten, Morrison, Helena W

“…Ischemic stroke is an acquired brain injury with gender-dependent outcomes. A persistent obstacle in understanding the sex-specific neuroinflammatory…”
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Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain by Loppi, Sanna H, Tavera-Garcia, Marco A, Scholpa, Natalie E, Maiyo, Boaz K, Becktel, Danielle A, Morrison, Helena W, Schnellmann, Rick G, Doyle, Kristian P

“…Following ischemic stroke, the degradation of myelin and other cellular membranes surpasses the lipid-processing capabilities of resident microglia and…”
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Experimental Traumatic Brain Injury Induces Chronic Glutamatergic Dysfunction in Amygdala Circuitry Known to Regulate Anxiety-Like Behavior by Beitchman, Joshua A, Griffiths, Daniel R, Hur, Yerin, Ogle, Sarah B, Bromberg, Caitlin E, Morrison, Helena W, Lifshitz, Jonathan, Adelson, P David, Thomas, Theresa Currier

“…Up to 50% of traumatic brain injury (TBI) survivors demonstrate persisting and late-onset anxiety disorders indicative of limbic system dysregulation, yet the…”
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Chronic consequences of ischemic stroke: Profiling brain injury and inflammation in a mouse model with reperfusion by Murphy, Devin P., Dickson, Denali C., Fatema, Arisha N., Carrasco, Nolan G., Doyle, Kristian P., Trouard, Theodore P., Morrison, Helena W.

“…Stroke is a pervasive and debilitating global health concern, necessitating innovative therapeutic strategies, especially during recovery. While existing…”
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Corrigendum: Experimental Traumatic Brain Injury Induces Chronic Glutamatergic Dysfunction in Amygdala Circuitry Known to Regulate Anxiety-Like Behavior by Beitchman, Joshua A, Griffiths, Daniel R, Hur, Yerin, Ogle, Sarah B, Bromberg, Caitlin E, Morrison, Helena W, Lifshitz, Jonathan, Adelson, P David, Currier Thomas, Theresa

“…[This corrects the article DOI: 10.3389/fnins.2019.01434.]…”
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Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice by Morrison, Helena W, Filosa, Jessica A

“…Highlights • Astrocyte Ca2+ dynamics are different in male and female mice after ischemia. • Sex differences in astrocyte AQP4 polarity and non-somatic S100β…”
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Stroke and the neurovascular unit: glial cells, sex differences, and hypertension by Morrison, Helena W, Filosa, Jessica A

“…A functional neurovascular unit (NVU) is central to meeting the brain's dynamic metabolic needs. Poststroke damage to the NVU within the ipsilateral hemisphere…”
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PACAP glycosides promote cell outgrowth in vitro and reduce infarct size after stroke in a preclinical model by Bernard, Kelsey, Dickson, Denali, Anglin, Bobbi L., Leandro Heien, M., Polt, Robin, Morrison, Helena W., Falk, Torsten

“…Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) is a pleiotropic peptide known to promote many beneficial processes following neural damage and cell…”
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Acute Post-Traumatic Sleep May Define Vulnerability to a Second Traumatic Brain Injury in Mice by Rowe, Rachel K, Harrison, Jordan L, Morrison, Helena W, Subbian, Vignesh, Murphy, Sean M, Lifshitz, Jonathan

“…Chronic neurological impairments can manifest from repetitive traumatic brain injury (rTBI), particularly when subsequent injuries occur before the initial…”
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Evaluation of microglia in a rodent model of Parkinson’s disease primed with L-DOPA after sub-anesthetic ketamine treatment by Pottenger, Ayumi E., Bartlett, Mitchell J., Sherman, Scott J., Falk, Torsten, Morrison, Helena W.

“…•We replicate that ketamine attenuates development of L-DOPA-induced dyskinesia.•Ketamine treatment leads to an increase of striatal interleukin-6 in…”
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Aging with Toxoplasma gondii results in pathogen clearance, resolution of inflammation, and minimal consequences to learning and memory by McGovern, Kathryn E., Cabral, Carla M., Morrison, Helena W., Koshy, Anita A.

“…Persistent inflammation has been identified as a contributor to aging-related neurodegenerative disorders such as Alzheimer’s disease. Normal aging, in the…”
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Examining the Associations between Post-Stroke Cognitive Function and Common Comorbid Conditions among Stroke Survivors by Morrison, Helena W, White, Melissa M, Rothers, Janet L, Taylor-Piliae, Ruth E

“…A considerable complication for stroke survivors is the subsequent development of cognitive decline or dementia. In this study, the relationship between the…”
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PNA5, A Novel Mas Receptor Agonist, Improves Neurovascular and Blood-Brain-Barrier Function in a Mouse Model of Vascular Cognitive Impairment and Dementia by Hoyer-Kimura, Christina, Hay, Meredith, Konhilas, John P, Morrison, Helena W, Methajit, Methawasin, Strom, Joshua, Polt, Robin, Salcedo, Victoria, Fricks, Joshua P, Kalya, Anjna, Pires, Paulo W

“…It is well established that decreased brain blood flow, increased reactive oxygen species production (ROS), and pro-inflammatory mechanisms accelerate…”
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Post-Stroke Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Attenuates Chronic Changes in Brain Metabolism, Increases Neurotransmitter Levels, and Improves Recovery by Nguyen, Thuy-Vi V, Crumpacker, Rachel H, Calderon, Kylie E, Garcia, Frankie G, Zbesko, Jacob C, Frye, Jennifer B, Gonzalez, Selena, Becktel, Danielle A, Yang, Tao, Tavera-Garcia, Marco A, Morrison, Helena W, Schnellmann, Rick G, Longo, Frank M, Doyle, Kristian P

“…The aim of this study was to test whether poststroke oral administration of a small molecule p75 neurotrophin receptor (p75 ) modulator (LM11A-31) can augment…”
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The Feasibility of Tai Chi Exercise as a Beneficial Mind-Body Intervention in a Group of Community-Dwelling Stroke Survivors with Symptoms of Depression by Taylor-Piliae, Ruth E., Morrison, Helena W., Hsu, Chiu-Hsieh (Paul), Whitman, Susan, Grandner, Michael

“…Depression is prevalent among one-third to two-thirds of acute and chronic stroke survivors. Despite the availability of pharmacotherapies and/or…”
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Assessment and Quantification of Foam Cells and Lipid Droplet–Accumulating Microglia in Mouse Brain Tissue Using BODIPY Staining by Maiyo, Boaz, Loppi, Sanna, Morrison, Helena, Doyle, Kristian

“…This paper presents a refined, user-friendly protocol for using boron-dipyrromethene (BODIPY) to assess and quantify foam cells and lipid droplet-accumulating…”
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Experiences of dual PHD-DNP nursing students during doctoral education by May, Jennifer T., Littzen, Chloe O.R., Morrison, Helena W., Loescher, Lois J.

“…Nursing doctoral education now includes an option with a growing national interest: the PhD-DNP dual degree. Although programs have existed for 10 years,…”
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Design and Synthesis of Brain Penetrant Glycopeptide Analogues of PACAP With Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism by Apostol, Christopher R, Bernard, Kelsey, Tanguturi, Parthasaradhireddy, Molnar, Gabriella, Bartlett, Mitchell J, Szabò, Lajos, Liu, Chenxi, Ortiz, J Bryce, Saber, Maha, Giordano, Katherine R, Green, Tabitha R F, Melvin, James, Morrison, Helena W, Madhavan, Lalitha, Rowe, Rachel K, Streicher, John M, Heien, Michael L, Falk, Torsten, Polt, Robin

“…There is an unmet clinical need for curative therapies to treat neurodegenerative disorders. Most mainstay treatments currently on the market only alleviate…”
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