Search Results - "Morrison, Brad E"

Parkinson’s disease and enhanced inflammatory response by Stojkovska, Iva, Wagner, Brandon M, Morrison, Brad E

“…Parkinson’s disease (PD) is the first and second most prevalent motor and neurodegenerative disease, respectively. The clinical symptoms of PD result from a…”
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Signaling and other functions of lipids in autophagy: a review by Soto-Avellaneda, Alejandro, Morrison, Brad E

“…The process of autophagy is integral to cellular function. In this process, proteins, organelles, and metabolites are engulfed in a lipid vesicle and…”
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Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity by Pfister, Jason A, Ma, Chi, Morrison, Brad E, D'Mello, Santosh R

“…Growing evidence suggests that sirtuins, a family of seven distinct NAD-dependent enzymes, are involved in the regulation of neuronal survival. Indeed, SIRT1…”
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FABP5-binding lipids regulate autophagy in differentiated SH-SY5Y cells by Soto-Avellaneda, Alejandro, Oxford, Alexandra E, Halla, Fabio, Vasquez, Peyton, Oe, Emily, Pugel, Anton D, Schoenfeld, Alyssa M, Tillman, Matthew C, Cuevas, André, Ortlund, Eric A, Morrison, Brad E

“…The motor features of Parkinson's disease result from loss of dopaminergic neurons in the substantia nigra with autophagy dysfunction being closely linked to…”
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Nonhistone Lysine Methylation as a Protein Degradation Signal by Lehning, Nicholas A., Morrison, Brad E.

“…Protein degradation is a fundamental feature of cellular life, and malfunction of this process is implicated in human disease. Ubiquitin tagging is the best…”
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The Role of NAD + and NAD + -Boosting Therapies in Inflammatory Response by IL-13 by Pugel, Anton D, Schoenfeld, Alyssa M, Alsaifi, Sara Z, Holmes, Jocelyn R, Morrison, Brad E

“…The essential role of nicotinamide adenine dinucleotide (NAD ) in redox reactions during oxidative respiration is well known, yet the coenzyme and regulator…”
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Central nervous system and peripheral cell labeling by vascular endothelial cadherin-driven lineage tracing in adult mice by Soto-Avellaneda, Alejandro, Morrison, Brad

“…Understanding the contribution of endothelial cells to the progenitor pools of adult tissues has the potential to inform therapies for human disease. To…”
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Discovery of nigral dopaminergic neurogenesis in adult mice by Morrison, Brad

“…Parkinson＇s disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms…”
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HDAC4 inhibits cell‐cycle progression and protects neurons from cell death by Majdzadeh, Nazanin, Wang, Lulu, Morrison, Brad E., Bassel‐Duby, Rhonda, Olson, Eric N., D'Mello, Santosh R.

“…HDAC4 is a Class II histone deacetylase (HDAC) that is highly expressed in the brain, but whose functional significance in the brain is not known. We show that…”
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Endothelial Cell Contributions to COVID-19 by Oxford, Alexandra E, Halla, Fabio, Robertson, Evan B, Morrison, Brad E

“…Understanding of the clinical, histological and molecular features of the novel coronavirus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2))…”
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Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis by Morrison, Brad E, Park, Stacy J, Mooney, Jill M, Mehrad, Borna

“…Invasive aspergillosis is a severe pneumonia that is usually fatal despite currently available therapy. The disease disproportionately afflicts…”
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Repurposing Drugs to Treat Heart and Brain Illness by Cantrell, Maranda S., Soto-Avellaneda, Alejandro, Wall, Jackson D., Ajeti, Aaron D., Morrison, Brad E., Warner, Lisa R., McDougal, Owen M.

“…Drug development is a complicated, slow and expensive process with high failure rates. One strategy to mitigate these factors is to recycle existing drugs with…”
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Neuroprotection by Histone Deacetylase-Related Protein by Morrison, Brad E., Majdzadeh, Nazanin, Zhang, Xiaoguang, Lyles, Aaron, Bassel-Duby, Rhonda, Olson, Eric N., D'Mello, Santosh R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Contributions of VPS35 Mutations to Parkinson’s Disease by Rahman, Abir A., Morrison, Brad E.

“…•A mutation in the retromer protein, VPS35, is known to cause PD.•VPS35 mutation affects retromer function, protein homeostasis and mitochondria.•Cell culture…”
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Nigral dopaminergic neuron replenishment in adult mice through VE-cadherin-expressing neural progenitor cells by Rahman, Abir A, Lai, Nathan K, Albright, Joshua E, Urquhart, Paige E, Webb, Abby R, Morrison, Brad E

“…The function of dopaminergic neurons in the substantia nigra is of central importance to the coordination of movement by the brain＇s basal ganglia circuitry…”
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Nestin-positive/SOX2−negative cells mediate adult neurogenesis of nigral dopaminergic neurons in mice by Albright, Joshua E., Stojkovska, Iva, Rahman, Abir A., Brown, Connor J., Morrison, Brad E.

“…[Display omitted] •Novel model developed for cell lineage tracing of dopaminergic neuron progenitors.•Nestin+ neural progenitors are responsible for…”
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Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide by Morrison, Brad E, Marcondes, Maria Cecilia Garibaldi, Nomura, Daniel K, Sanchez-Alavez, Manuel, Sanchez-Gonzalez, Alejandro, Saar, Indrek, Kim, Kwang-Soo, Bartfai, Tamas, Maher, Pamela, Sugama, Shuei, Conti, Bruno

“…Inflammation and its mediators, including cytokines and reactive oxygen species, are thought to contribute to neurodegeneration. In the mouse brain, we found…”
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Enhanced Hyaluronan Signaling and Autophagy Dysfunction by VPS35 D620N by Rahman, Abir A., Soto-Avellaneda, Alejandro, Yong Jin, Hyun, Stojkovska, Iva, Lai, Nathan K., Albright, Joshua E., Webb, Abby R., Oe, Emily, Valarde, Jacob P., Oxford, Alexandra E., Urquhart, Paige E., Wagner, Brandon, Brown, Connor, Amado, Isabella, Vasquez, Peyton, Lehning, Nicholas, Grozdanov, Veselin, Pu, Xinzhu, Danzer, Karin M., Morrison, Brad E.

“…•VPS35 D620N inhibits autophagy in a loss-of-function manner.•RNA Seq identifies extracellular matrix-receptor and PI3K-AKT pathways affected by VPS35…”
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Cutting Edge: IL-13R alpha 1 Expression in Dopaminergic Neurons Contributes to Their Oxidative Stress-Mediated Loss following Chronic Peripheral Treatment with Lipopolysaccharide by Morrison, Brad E, Marcondes, Maria Cecilia Garibaldi, Nomura, Daniel K, Sanchez-Alavez, Manuel, Sanchez-Gonzalez, Alejandro, Saar, Indrek, Kim, Kwang-Soo, Bartfai, Tamas, Maher, Pamela, Sugama, Shuei, Conti, Bruno

“…Inflammation and its mediators, including cytokines and reactive oxygen species, are thought to contribute to neurodegeneration. In the mouse brain, we found…”
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A Fragment of Apolipoprotein E4 Leads to the Downregulation of a CXorf56 Homologue, a Novel ER-Associated Protein, and Activation of BV2 Microglial Cells by Rohn, Troy T., Hayden, Eric J., Oxford, Alexandra E., Brown, Raquel J., Isho, Noail F., Day, Ryan J., Mack, Jacob M., Pollock, Tanner B., Morrison, Brad E.

“…Despite the fact that harboring the apolipoprotein E4 (APOE4) allele represents the single greatest risk factor for late-onset Alzheimer’s disease (AD), the…”
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