Search Results - "Morris, John C"

Transforming growth factor-β: A therapeutic target for cancer by Haque, Sulsal, Morris, John C.

“…Transforming growth factor-β (TGF-β) regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and…”
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Alzheimer's disease: the challenge of the second century by Holtzman, David M, Morris, John C, Goate, Alison M

“…Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most common cause of dementia with an estimated prevalence of 30…”
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Open access series of imaging studies: longitudinal MRI data in nondemented and demented older adults by Marcus, Daniel S, Fotenos, Anthony F, Csernansky, John G, Morris, John C, Buckner, Randy L

“…The Open Access Series of Imaging Studies is a series of neuroimaging data sets that are publicly available for study and analysis. The present MRI data set…”
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Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease by Musiek, Erik S, Bhimasani, Meghana, Zangrilli, Margaret A, Morris, John C, Holtzman, David M, Ju, Yo-El S

“…Circadian rhythm disturbances occur in symptomatic Alzheimer disease (AD) and have been hypothesized to contribute to disease pathogenesis. However, it is…”
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Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease by Aschenbrenner, Andrew J, Gordon, Brian A, Benzinger, Tammie L.S, Morris, John C, Hassenstab, Jason J

“…OBJECTIVETo examine the independent and interactive influences of neuroimaging biomarkers on retrospective cognitive decline. METHODSA total of 152 middle-aged…”
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Interleukin-15 biology and its therapeutic implications in cancer by Steel, Jason C, Waldmann, Thomas A, Morris, John C

“…Cancer immunotherapy is designed to stimulate the immune system to reject and destroy tumors. Recently, interleukin-15 (IL-15), a member of the four α-helix…”
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Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells by Morrison, Brian J, Steel, Jason C, Morris, John C

“…It has been proposed that cancer establishment, maintenance, and recurrence may be attributed to a unique population of tumor cells termed cancer-initiating…”
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Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction by Nation, Daniel A., Sweeney, Melanie D., Montagne, Axel, Sagare, Abhay P., D’Orazio, Lina M., Pachicano, Maricarmen, Sepehrband, Farshid, Nelson, Amy R., Buennagel, David P., Harrington, Michael G., Benzinger, Tammie L. S., Fagan, Anne M., Ringman, John M., Schneider, Lon S., Morris, John C., Chui, Helena C., Law, Meng, Toga, Arthur W., Zlokovic, Berislav V.

“…Vascular contributions to cognitive impairment are increasingly recognized 1 – 5 as shown by neuropathological 6 , 7 , neuroimaging 4 , 8 – 11 , and…”
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Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study by Vos, Stephanie JB, MSc, Xiong, Chengjie, Prof, Visser, Pieter Jelle, MD, Jasielec, Mateusz S, MS, Hassenstab, Jason, PhD, Grant, Elizabeth A, PhD, Cairns, Nigel J, Prof, Morris, John C, Prof, Holtzman, David M, Prof, Fagan, Anne M, Prof

“…Summary Background New research criteria for preclinical Alzheimer's disease have been proposed, which include stages for cognitively normal individuals with…”
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Assessment of Racial Disparities in Biomarkers for Alzheimer Disease by Morris, John C, Schindler, Suzanne E, McCue, Lena M, Moulder, Krista L, Benzinger, Tammie L S, Cruchaga, Carlos, Fagan, Anne M, Grant, Elizabeth, Gordon, Brian A, Holtzman, David M, Xiong, Chengjie

“…Racial differences in molecular biomarkers for Alzheimer disease may suggest race-dependent biological mechanisms. To ascertain whether there are racial…”
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Sleep quality and preclinical Alzheimer disease by Ju, Yo-El S, McLeland, Jennifer S, Toedebusch, Cristina D, Xiong, Chengjie, Fagan, Anne M, Duntley, Stephen P, Morris, John C, Holtzman, David M

“…Sleep and circadian problems are very common in Alzheimer disease (AD). Recent animal studies suggest a bidirectional relationship between sleep and β-amyloid…”
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Loss of Brain Aerobic Glycolysis in Normal Human Aging by Goyal, Manu S., Vlassenko, Andrei G., Blazey, Tyler M., Su, Yi, Couture, Lars E., Durbin, Tony J., Bateman, Randall J., Benzinger, Tammie L.-S., Morris, John C., Raichle, Marcus E.

“…The normal aging human brain experiences global decreases in metabolism, but whether this affects the topography of brain metabolism is unknown. Here we…”
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Does institutional location matter? The effect of agency type on resource distribution for nonpoint water pollution by Aistrup, Joseph A., Morris, John C.

“…ABSTRACT With the rejuvenated emphasis on nonpoint pollution under the Water Quality Act (WQA) of 1987, states seek ways to address nonpoint pollution sources…”
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Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury by Suárez-Calvet, Marc, Araque Caballero, Miguel Ángel, Kleinberger, Gernot, Bateman, Randall J, Fagan, Anne M, Morris, John C, Levin, Johannes, Danek, Adrian, Ewers, Michael, Haass, Christian

“…Emerging evidence supports a role for innate immunity and microglia in Alzheimer's disease (AD) pathophysiology. However, no marker related to microglia has…”
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Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease by Tarawneh, Rawan, D'Angelo, Gina, Crimmins, Dan, Herries, Elizabeth, Griest, Terry, Fagan, Anne M, Zipfel, Gregory J, Ladenson, Jack H, Morris, John C, Holtzman, David M

“…Synaptic loss is an early pathologic substrate of Alzheimer disease (AD). Neurogranin is a postsynaptic neuronal protein that has demonstrated utility as a…”
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Version 3 of the National Alzheimer’s Coordinating Center’s Uniform Data Set by Besser, Lilah, Kukull, Walter, Knopman, David S, Chui, Helena, Galasko, Douglas, Weintraub, Sandra, Jicha, Gregory, Carlsson, Cynthia, Burns, Jeffrey, Quinn, Joseph, Sweet, Robert A, Rascovsky, Katya, Teylan, Merilee, Beekly, Duane, Thomas, George, Bollenbeck, Mark, Monsell, Sarah, Mock, Charles, Zhou, Xiao Hua, Thomas, Nicole, Robichaud, Elizabeth, Dean, Margaret, Hubbard, Janene, Jacka, Mary, Schwabe-Fry, Kristen, Wu, Joylee, Phelps, Creighton, Morris, John C

“…INTRODUCTION:In 2015, the US Alzheimer’s Disease Centers (ADC) implemented Version 3 of the Uniform Data Set (UDS). This paper describes the history of Version…”
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Functional connectivity and graph theory in preclinical Alzheimer's disease by Brier, Matthew R, Thomas, Jewell B, Fagan, Anne M, Hassenstab, Jason, Holtzman, David M, Benzinger, Tammie L, Morris, John C, Ances, Beau M

“…Abstract Alzheimer's disease (AD) has a long preclinical phase in which amyloid and tau cerebral pathology accumulate without producing cognitive symptoms…”
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Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging by Schindler, Suzanne E., Gray, Julia D., Gordon, Brian A., Xiong, Chengjie, Batrla-Utermann, Richard, Quan, Marian, Wahl, Simone, Benzinger, Tammie L.S., Holtzman, David M., Morris, John C., Fagan, Anne M.

“…Levels of amyloid β peptide 42 (Aβ42), total tau, and phosphorylated tau-181 are well-established cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease,…”
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Persistent metabolic youth in the aging female brain by Goyal, Manu S., Blazey, Tyler M., Su, Yi, Couture, Lars E., Durbin, Tony J., Bateman, Randall J., Benzinger, Tammie L.-S., Morris, John C., Raichle, Marcus E., Vlassenko, Andrei G.

“…Sex differences influence brain morphology and physiology during both development and aging. Here we apply a machine learning algorithm to a multiparametric…”
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Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders by Yang, Chengran, Farias, Fabiana H. G., Ibanez, Laura, Suhy, Adam, Sadler, Brooke, Fernandez, Maria Victoria, Wang, Fengxian, Bradley, Joseph L., Eiffert, Brett, Bahena, Jorge A., Budde, John P., Li, Zeran, Dube, Umber, Sung, Yun Ju, Mihindukulasuriya, Kathie A., Morris, John C., Fagan, Anne M., Perrin, Richard J., Benitez, Bruno A., Rhinn, Herve, Harari, Oscar, Cruchaga, Carlos

“…Understanding the tissue-specific genetic controls of protein levels is essential to uncover mechanisms of post-transcriptional gene regulation. In this study,…”
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