Search Results - "Morris, Gavin E"

Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides by Dixon, James E., Osman, Gizem, Morris, Gavin E., Markides, Hareklea, Rotherham, Michael, Bayoussef, Zahia, Haj, Alicia J. El, Denning, Chris, Shakesheff, Kevin M.

“…Protein transduction domains (PTDs) are powerful nongenetic tools that allow intracellular delivery of conjugated cargoes to modify cell behavior. Their use in…”
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In vitro , in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss by Chernyavsky, Igor L, Russell, Richard J, Saunders, Ruth M, Morris, Gavin E, Berair, Rachid, Singapuri, Amisha, Chachi, Latifa, Mansur, Adel H, Howarth, Peter H, Dennison, Patrick, Chaudhuri, Rekha, Bicknell, Stephen, Rose, Felicity R A J, Siddiqui, Salman, Brook, Bindi S, Brightling, Christopher E

“…Bronchial thermoplasty is a treatment for asthma. It is currently unclear whether its histopathological impact is sufficiently explained by the proportion of…”
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An automated fabrication strategy to create patterned tubular architectures at cell and tissue scales by Othman, Rebeen, E Morris, Gavin, Shah, Disheet A, Hall, Stephen, Hall, Graham, Wells, Keith, Shakesheff, Kevin M, Dixon, James E

“…The use of materials to impose tissue-like architecture at cell resolution will be important if engineered functional replacements for damaged cardiovascular,…”
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Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses by Morris, Gavin E, Parker, Lisa C, Ward, Jon R, Jones, Elizabeth C, Whyte, Moira K.B, Brightling, Christopher E, Bradding, Peter, Dower, Steven K, Sabroe, Ian

“…Viral and bacterial pathogens cause inflammation via Toll-like receptor (TLR) signaling. We have shown that effective responses to LPS may depend on…”
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Agonists of Toll-like Receptors 2 and 4 Activate Airway Smooth Muscle via Mononuclear Leukocytes by Morris, Gavin E, Whyte, Moira K. B, Martin, Gillian F, Jose, Peter J, Dower, Steven K, Sabroe, Ian

“…Toll-like receptors 2 and 4 (TLR2, TLR4) enable cellular responses to bacterial lipoproteins, LPS, and endogenous mediators of cell damage. They have an…”
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The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis by Karamanavi, Elisavet, McVey, David G., van der Laan, Sander W., Stanczyk, Paulina J., Morris, Gavin E., Wang, Yifan, Yang, Wei, Chan, Kenneth, Poston, Robin N., Luo, Jun, Zhou, Xinmiao, Gong, Peng, Jones, Peter D., Cao, Junjun, Kostogrys, Renata B., Webb, Tom R., Pasterkamp, Gerard, Yu, Haojie, Xiao, Qingzhong, Greer, Peter A., Stringer, Emma J., Samani, Nilesh J., Ye, Shu

“…Genome-wide association studies have discovered a link between genetic variants on human chromosome 15q26.1 and increased coronary artery disease (CAD)…”
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Coronary Artery Disease–Associated LIPA Coding Variant rs1051338 Reduces Lysosomal Acid Lipase Levels and Activity in Lysosomes by Morris, Gavin E, Braund, Peter S, Moore, Jasbir S, Samani, Nilesh J, Codd, Veryan, Webb, Tom R

“…OBJECTIVE—Genome-wide association studies have linked variants at chromosome 10q23 with increased coronary artery disease risk. The disease-associated variants…”
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HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis by Aravani, Dimitra, Morris, Gavin E, Jones, Peter D, Tattersall, Helena K, Karamanavi, Elisavet, Kaiser, Michael A, Kostogrys, Renata B, Ghaderi Najafabadi, Maryam, Andrews, Sarah L, Nath, Mintu, Ye, Shu, Stringer, Emma J, Samani, Nilesh J, Webb, Tom R

“…BACKGROUND:Genome-wide association studies have identified chromosome 14q32 as a locus for coronary artery disease. The disease-associated variants fall in a…”
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The integrin ligand SVEP1 regulates GPCR‐mediated vasoconstriction via integrins α9β1 and α4β1 by Morris, Gavin E., Denniff, Matthew J., Karamanavi, Elisavet, Andrews, Sarah A., Kostogrys, Renata B., Bountziouka, Vasiliki, Ghaderi‐Najafabadi, Maryam, Shamkhi, Noor, McConnell, George, Kaiser, Michael A., Carleton, Laura, Schofield, Christine, Kessler, Thorsten, Rainbow, Richard D., Samani, Nilesh J., Webb, Thomas R.

“…Background and Purpose Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells (VSMCs). Several integrins directly…”
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A novel technique for the production of electrospun scaffolds with tailored three-dimensional micro-patterns employing additive manufacturing by Rogers, Catherine M, Morris, Gavin E, Gould, Toby W A, Bail, Robert, Toumpaniari, Sotiria, Harrington, Helen, Dixon, James E, Shakesheff, Kevin M, Segal, Joel, Rose, Felicity R A J

“…Electrospinning is a common technique used to fabricate fibrous scaffolds for tissue engineering applications. There is now growing interest in assessing the…”
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Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2 by Morris, Gavin E., Nelson, Carl P., Standen, Nicholas B., Challiss, R.A. John, Willets, Jonathon M.

“…Aims Prolonged endothelin (ET) receptor signalling causes vasoconstriction and can lead to hypertension, vascular smooth muscle hypertrophy, and hyperplasia…”
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G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling by MORRIS, Gavin E, NELSON, Carl P, EVERITT, Diane, BRIGHTON, Paul J, STANDEN, Nicholas B, CHALLISS, R. A. John, WILLETS, Jonathon M

“…prolonged P2Y-receptor signalling can cause vasoconstriction leading to hypertension, vascular smooth muscle hypertrophy, and hyperplasia. G protein-coupled…”
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Regulation of Oxytocin Receptor Responsiveness by G Protein-Coupled Receptor Kinase 6 in Human Myometrial Smooth Muscle by Willets, Jonathon M, Brighton, Paul J, Mistry, Rajendra, Morris, Gavin E, Konje, Justin C, Challiss, R. A. John

“…Oxytocin plays an important role in the progression, timing, and modulation of uterine contraction during labor and is widely used as an uterotonic agent. We…”
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Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall by Bridge, Jack C, Aylott, Jonathan W, Brightling, Christopher E, Ghaemmaghami, Amir M, Knox, Alan J, Lewis, Mark P, Rose, Felicity R A J, Morris, Gavin E

“…Electrospinning is a highly adaptable method producing porous 3D fibrous scaffolds that can be exploited in in vitro cell culture. Alterations to intrinsic…”
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The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis by Karamanavi, Elisavet, McVey, David G., van der Laan, Sander W., Stanczyk, Paulina J., Morris, Gavin E., Wang, Yifan, Yang, Wei, Chan, Kenneth, Poston, Robin N., Luo, Jun, Zhou, Xinmiao, Gong, Peng, Jones, Peter D., Cao, Junjun, Kostogrys, Renata B., Webb, Tom R., Pasterkamp, Gerard, Yu, Haojie, Xiao, Qingzhong, Greer, Peter A., Stringer, Emma J., Samani, Nilesh J., Ye, Shu

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Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall by Bridge, Jack C., Aylott, Jonathan W., Brightling, Christopher E., Ghaemmaghami, Amir M., Knox, Alan J., Lewis, Mark P., Rose, Felicity R.A.J., Morris, Gavin E.

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Purinoceptor Signaling in Arterial Smooth Muscle is Regulated by G-Protein-Coupled Recptor Kinase-2 by Morris, Gavin E., Everitt, Diane E., Challiss, John, Willets, John M.

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Arrestins 2 and 3 differentially regulate ETA and P2Y2 receptor-mediated cell signaling and migration in arterial smooth muscle by Morris, Gavin E, Nelson, Carl P, Brighton, Paul J, Standen, Nicholas B, Challiss, R A John, Willets, Jonathon M

“…Overstimulation of endothelin type A (ET(A)) and nucleotide (P2Y) Gα(q)-coupled receptors in vascular smooth muscle causes vasoconstriction, hypertension, and,…”
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