Search Results - "Morris, Christopher J"

Circadian misalignment increases cardiovascular disease risk factors in humans by Morris, Christopher J., Purvis, Taylor E., Hu, Kun, Scheer, Frank A. J. L.

“…Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. This increased risk cannot be fully explained by classic risk factors…”
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Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans by Morris, Christopher J., Yang, Jessica N., Garcia, Joanna I., Myers, Samantha, Bozzi, Isadora, Wang, Wei, Buxton, Orfeu M., Shea, Steven A., Scheer, Frank A. J. L.

“…Significance It is established that glucose tolerance decreases from the morning to the evening, and that shift work is a risk factor for diabetes. However,…”
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Sex differences in the circadian misalignment effects on energy regulation by Qian, Jingyi, Morris, Christopher J., Caputo, Rosanna, Wang, Wei, Garaulet, Marta, Scheer, Frank A. J. L.

“…Shift work causes circadian misalignment and is a risk factor for obesity. While some characteristics of the human circadian system and energy metabolism…”
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Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans by Qian, Jingyi, Morris, Christopher J., Caputo, Rosanna, Garaulet, Marta, Scheer, Frank A. J. L.

“…The human circadian system regulates hunger independently of behavioral factors, resulting in a trough in the biological morning and a peak in the biological…”
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The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors by Scheer, Frank A.J.L., Morris, Christopher J., Shea, Steven A.

“…Objective: Despite the extended overnight fast, paradoxically, people are typically not ravenous in the morning and breakfast is typically the smallest meal of…”
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Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers by Morris, Christopher J, Purvis, Taylor E, Mistretta, Joseph, Scheer, Frank A. J. L

“…Context: Shift work is a risk factor for diabetes. The separate effects of the endogenous circadian system and circadian misalignment (ie, misalignment between…”
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Circadian misalignment increases 24‐hour acylated ghrelin in chronic shift workers: a randomized crossover trial by Qian, Jingyi, Morris, Christopher J., Caputo, Rosanna, Scheer, Frank A. J. L.

“…Objective Shift workers typically experience misalignment between their circadian system and behavioral/environmental cycles and have an increased risk for…”
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Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers by Morris, Christopher J., Purvis, Taylor E., Mistretta, Joseph, Hu, Kun, Scheer, Frank A. J. L.

“…Shift work is a risk factor for inflammation, hypertension, and cardiovascular disease. This increased risk cannot be fully explained by classical risk…”
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Rapid and low power laser actuation of sputter-deposited NiTi shape memory alloy (SMA) MEMS thermal bimorph actuators by Knick, Cory R., Smith, Gabriel L., Morris, Christopher J., Bruck, Hugh A.

“…[Display omitted] •Device characterization of sub-micron thin NiTi SMA bimorph actuators created using standard MEMS processing in cleanroom.•New fabrication…”
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The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet‐Induced Thermogenesis by Morris, Christopher J., Garcia, Joanna I., Myers, Samantha, Yang, Jessica N., Trienekens, Noortje, Scheer, Frank A.J.L.

“…Objective Diet‐induced thermogenesis (DIT) is lower in the evening and at night than in the morning. This may help explain why meal timing affects body weight…”
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Effects of circadian misalignment on cognition in chronic shift workers by Chellappa, Sarah L., Morris, Christopher J., Scheer, Frank A. J. L.

“…Shift work is associated with increased human operational errors, presumably due to the circadian timing system that inhibits optimal cognitive function during…”
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ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection by Mistry, Jayna J., Marlein, Christopher R., Moore, Jamie A., Hellmich, Charlotte, Wojtowicz, Edyta E., Smith, James G. W., Macaulay, Iain, Sun, Yu, Morfakis, Adam, Patterson, Angela, Horton, Rebecca H., Divekar, Devina, Morris, Christopher J., Haestier, Anna, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.

“…Hematopoietic stem cells (HSCs) undergo rapid expansion in response to stress stimuli. Here we investigate the bioenergetic processes which facilitate the HSC…”
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Daily circadian misalignment impairs human cognitive performance task-dependently by Chellappa, Sarah L., Morris, Christopher J., Scheer, Frank A. J. L.

“…Shift work increases the risk for human errors, such that drowsiness due to shift work has contributed to major industrial disasters, including Space Shuttle…”
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The impact of the circadian timing system on cardiovascular and metabolic function by Morris, Christopher J, Yang, Jessica N, Scheer, Frank A J L

“…Epidemiological studies show that adverse cardiovascular events peak in the morning (i.e., between 6 AM and noon) and that shift work is associated with…”
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Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions by Arble, Deanna M, Bass, Joseph, Behn, Cecilia Diniz, Butler, Matthew P, Challet, Etienne, Czeisler, Charles, Depner, Christopher M, Elmquist, Joel, Franken, Paul, Grandner, Michael A, Hanlon, Erin C, Keene, Alex C, Joyner, Michael J, Karatsoreos, Ilia, Kern, Philip A, Klein, Samuel, Morris, Christopher J, Pack, Allan I, Panda, Satchidananda, Ptacek, Louis J, Punjabi, Naresh M, Sassone-Corsi, Paolo, Scheer, Frank A, Saxena, Richa, Seaquest, Elizabeth R, Thimgan, Matthew S, Van Cauter, Eve, Wright, Kenneth P

“…A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on…”
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Structural insights into i-motif DNA structures in sequences from the insulin-linked polymorphic region by Guneri, Dilek, Alexandrou, Effrosyni, El Omari, Kamel, Dvořáková, Zuzana, Chikhale, Rupesh V., Pike, Daniel T. S., Waudby, Christopher A., Morris, Christopher J., Haider, Shozeb, Parkinson, Gary N., Waller, Zoë A. E.

“…The insulin-linked polymorphic region is a variable number of tandem repeats region of DNA in the promoter of the insulin gene that regulates transcription of…”
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Using a multi-omic approach to investigate the mechanism of 12-bis-THA activity against Burkholderia thailandensis by Pattinson, Adam, Bahia, Sandeep, Le Gall, Gwénaëlle, Morris, Christopher J, Harding, Sarah V, McArthur, Michael

“…is the causative agent of the tropical disease, melioidosis. It is intrinsically resistant to many antimicrobials and treatment requires an onerous regimen of…”
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Pegylation of Antimicrobial Peptides Maintains the Active Peptide Conformation, Model Membrane Interactions, and Antimicrobial Activity while Improving Lung Tissue Biocompatibility following Airway Delivery by Morris, Christopher J, Beck, Konrad, Fox, Marc A, Ulaeto, David, Clark, Graeme C, Gumbleton, Mark

“…Antimicrobial peptides (AMPs) have therapeutic potential, particularly for localized infections such as those of the lung. Here we show that airway…”
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Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment by Morris, Christopher J., Rolf, Michael G., Starnes, Linda, Villar, Inmaculada C., Pointon, Amy, Kimko, Holly, Di Veroli, Giovanni Y.

“…Pharmaceutical companies routinely screen compounds for hemodynamics related safety risk. In vitro secondary pharmacology is initially used to prioritize…”
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Understanding the Influence of a Bifunctional Polyethylene Glycol Derivative in Protein Corona Formation around Iron Oxide Nanoparticles by Ruiz, Amalia, Alpízar, Adán, Beola, Lilianne, Rubio, Carmen, Gavilán, Helena, Marciello, Marzia, Rodríguez-Ramiro, Ildefonso, Ciordia, Sergio, Morris, Christopher J, Morales, María Del Puerto

“…Superparamagnetic iron oxide nanoparticles are one of the most prominent agents used in theranostic applications, with MRI imaging the main application…”
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