Search Results - "Morrin, Helen R."

Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels by Campbell, Elizabeth J, Dachs, Gabi U, Morrin, Helen R, Davey, Valerie C, Robinson, Bridget A, Vissers, Margreet C M

“…The transcription factor hypoxia inducible factor (HIF) -1 drives tumor growth and metastasis and is associated with poor prognosis in breast cancer. Ascorbate…”
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Ascorbate content of clinical glioma tissues is related to tumour grade and to global levels of 5-hydroxymethyl cytosine by Crake, Rebekah L. I., Burgess, Eleanor R., Wiggins, George A. R., Magon, Nicholas J., Das, Andrew B., Vissers, Margreet C. M., Morrin, Helen R., Royds, Janice A., Slatter, Tania L., Robinson, Bridget A., Phillips, Elisabeth, Dachs, Gabi U.

“…Gliomas are incurable brain cancers with poor prognosis, with epigenetic dysregulation being a distinctive feature. 5-hydroxymethylcytosine (5-hmC), an…”
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Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics by White, Rebecca, Nonis, Maria, Pearson, John F, Burgess, Eleanor, Morrin, Helen R, Pullar, Juliet M, Spencer, Emma, Vissers, Margreet C M, Robinson, Bridget A, Dachs, Gabi U

“…Vitamin C (ascorbate) acts as an antioxidant and enzyme cofactor, and plays a vital role in human health. Vitamin C status can be affected by illness, with low…”
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Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in Patients With Colon Cancer: A Clinical Intervention Study by Dachs, Gabi U, Gandhi, Jamish, Wohlrab, Christina, Carr, Anitra C, Morrin, Helen R, Pullar, Juliet M, Bayer, Simone B, Eglinton, Tim W, Robinson, Bridget A, Vissers, Margreet C M

“…The use of high dose ascorbate infusions in cancer patients is widespread, but without evidence of efficacy. Several mechanisms whereby ascorbate could affect…”
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Increased Ascorbate Content of Glioblastoma Is Associated With a Suppressed Hypoxic Response and Improved Patient Survival by Burgess, Eleanor R, Crake, Rebekah L I, Phillips, Elisabeth, Morrin, Helen R, Royds, Janice A, Slatter, Tania L, Wiggins, George A R, Vissers, Margreet C M, Robinson, Bridget A, Dachs, Gabi U

“…Glioblastoma multiforme is a challenging disease with limited treatment options and poor survival. Glioblastoma tumours are characterised by hypoxia that…”
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Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: relationships with markers of tumor hypoxia and microvascularity by Currie, Margaret J., PhD, Beardsley, Brooke E., MBChB, Harris, Gavin C., FRCPath, Gunningham, Sarah P., PhD, Dachs, Gabi U., PhD, Dijkstra, Birgit, FRACS, Morrin, Helen R., BSc, Wells, J. Elisabeth, PhD, Robinson, Bridget A., MD

“…Summary We performed immunohistochemical analysis of 3 cancer stem cell–related markers (CD44+ /CD24−/low , aldehyde dehydrogenase [ALDH]-1, CD133) in 94…”
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The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression by Hanrahan, Vickie, Currie, Margaret J, Gunningham, Sarah P, Morrin, Helen R, Scott, Prudence AE, Robinson, Bridget A, Fox, Stephen B

“…Angiogenesis is essential for tumour growth and metastasis. It is controlled by angiogenic factors, one of the most important being vascular endothelial growth…”
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Research Use of Biospecimens from Deceased Individuals: A Call for Greater Regulatory Harmonization by Bledsoe, Marianna J, Lawlor, Rita T, Morrin, Helen R

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A profile of prognostic and molecular factors in European and Māori breast cancer patients by Dachs, Gabi U, Kano, Maiko, Volkova, Ekaterina, Morrin, Helen R, Davey, Valerie C L, Harris, Gavin C, Cheale, Michelle, Frampton, Christopher, Currie, Margaret J, Wells, J Elisabeth, Robinson, Bridget A

“…New Zealand Māori have a poorer outcome from breast cancer than non-Māori, yet prognostic data are sparse. The objective of this study was to quantify levels…”
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APC Mutations Are Not Confined to Hotspot Regions in Early-Onset Colorectal Cancer by Aitchison, Alan, Hakkaart, Christopher, Day, Robert C, Morrin, Helen R, Frizelle, Frank A, Keenan, Jacqueline I

“…While overall colorectal cancer (CRC) cases have been declining worldwide there has been an increase in the incidence of the disease among patients under 50…”
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The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer by Kazantseva, Marina, Mehta, Sunali, Eiholzer, Ramona A., Gimenez, Gregory, Bowie, Sara, Campbell, Hamish, Reily-Bell, Ashley L., Roth, Imogen, Ray, Sankalita, Drummond, Catherine J., Reid, Glen, Joruiz, Sebastien M., Wiles, Anna, Morrin, Helen R., Reader, Karen L., Hung, Noelyn A., Baird, Margaret A., Slatter, Tania L., Braithwaite, Antony W.

“…Prostate cancer is the second most common cancer in men, for which there are no reliable biomarkers or targeted therapies. Here we demonstrate that elevated…”
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Phosphohistone H3 outperforms Ki67 as a marker of outcome for breast cancer patients by Gerring, Zac, Pearson, John F, Morrin, Helen R, Robinson, Bridget A, Harris, Gavin C, Walker, Logan C

“…Aims The proliferation marker Ki67 has been extensively investigated as a prognostic factor in breast cancer, but has not gained widespread clinical…”
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RNAscope compatibility with image analysis platforms for the quantification of tissue-based colorectal cancer biomarkers in archival formalin-fixed paraffin-embedded tissue by Morley-Bunker, Arthur E., Wiggins, George A.R., Currie, Margaret J., Morrin, Helen R., Whitehead, Martin R., Eglinton, Tim, Pearson, John, Walker, Logan C.

“…•RNA in situ expression quantification reliably achieved with image analysis methods.•Image analysis methods perform at similar levels to…”
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Intronic TP53 Polymorphisms Are Associated with Increased [DELTA]133TP53 Transcript, Immune Infiltration and Cancer Risk by Eiholzer, Ramona A, Mehta, Sunali, Kazantseva, Marina, Drummond, Catherine J, McKinney, Cushla, Young, Katie, Slater, David, Morten, Brianna C, Avery-Kiejda, Kelly A, Lasham, Annette, Fleming, Nicholas, Morrin, Helen R, Reader, Karen, Royds, Janice A, Landmann, Michael, Petrich, Simone, Reddel, Roger, Huschtscha, Lily, Taha, Ahmad, Hung, Noelyn A, Slatter, Tania L, Braithwaite, Antony W

“…We investigated the influence of genetic variants, called single nucleotide polymorphisms (SNP) in the TP53 tumour suppressor gene, on cancer risk, clinical…”
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The G-Protein―Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis by NIKITENKO, Leonid L, LEEK, Russell, HARRIS, Adrian L, FOX, Stephen B, HENDERSON, Stephen, PILLAY, Nischalan, TURLEY, Helen, GENERALI, Daniele, GUNNINGHAM, Sarah, MORRIN, Helen R, PELLAGATTI, Andrea, REES, Margaret C. P

“…The G-protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) and its ligand peptide adrenomedullin (encoded by ADM gene) are implicated in…”
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Intronic TP53 Polymorphisms Are Associated with Increased Δ133TP53 Transcript, Immune Infiltration and Cancer Risk by Eiholzer, Ramona A., Mehta, Sunali, Kazantseva, Marina, Drummond, Catherine J., McKinney, Cushla, Young, Katie, Slater, David, Morten, Brianna C., Avery-Kiejda, Kelly A., Lasham, Annette, Fleming, Nicholas, Morrin, Helen R., Reader, Karen, Royds, Janice A., Landmann, Michael, Petrich, Simone, Reddel, Roger, Huschtscha, Lily, Taha, Ahmad, Hung, Noelyn A., Slatter, Tania L., Braithwaite, Antony W.

“…We investigated the influence of selected TP53 SNPs in exon 4 and intron 4 on cancer risk, clinicopathological features and expression of TP53 isoforms. The…”
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The rs11515 Polymorphism Is More Frequent and Associated With Aggressive Breast Tumors with Increased ANRIL and Decreased p16 (INK4a) Expression by Royds, Janice A, Pilbrow, Anna P, Ahn, Antonio, Morrin, Helen R, Frampton, Chris, Russell, I Alasdair, Moravec, Christine S, Sweet, Wendy E, Tang, W H Wilson, Currie, Margaret J, Hung, Noelyn A, Slatter, Tania L

“…Chromosome position 9p21 encodes three-tumor suppressors p16(INK4a), p14(ARF), and p15(INK4b) and the long non-coding RNA ANRIL (antisense non-coding RNA in…”
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Sustaining a biobank through a series of earthquake swarms: lessons learned from our New Zealand experience by Morrin, Helen R, Robinson, Bridget A

“…In the early hours of September 4, 2010, the city of Christchurch in New Zealand was awakened by a major magnitude 7.1 earthquake event that was the start of a…”
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Caspase Recruitment Domain-Containing protein 15 mutations in patients with colorectal cancer by ROBERTS, Rebecca L, GEARRY, Richard B, ALLINGTON, Melanie D. E, MORRIN, Helen R, ROBINSON, Bridget A, FRIZELLE, Frank A

“…The caspase recruitment domain-containing protein 15 (CARD15) plays a crucial role in mediating the innate immune response. Mutations within this protein have…”
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Phosphohistone H 3 outperforms K i67 as a marker of outcome for breast cancer patients by Gerring, Zac, Pearson, John F, Morrin, Helen R, Robinson, Bridget A, Harris, Gavin C, Walker, Logan C

“…Aims The proliferation marker Ki67 has been extensively investigated as a prognostic factor in breast cancer, but has not gained widespread clinical…”
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