Safety Aspects and Rational Use of Single Intramuscular Dose Ceftriaxone: Clinical Insights on the Management of Uncomplicated Gonococcal Infections

Safety Aspects and Rational Use of Single Intramuscular Dose Ceftriaxone: Clinical Insights on the Management of Uncomplicated Gonococcal Infections

Gonorrhea, a sexually transmitted infection caused by Neisseria gonorrhoeae, is a grave public health concern. Gonorrhea is the second most reported sexually transmitted infection worldwide. The treatment of uncomplicated gonococcal infections has evolved dramatically in response to the emergence of...

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Bibliographic Details
Published in:Drug, healthcare and patient safety Vol. 15; pp. 159 - 170
Main Authors: Allen, George P, Morrill, Haley L
Format: Journal Article
Language:English
Published: Dove Medical Press Limited 30-11-2023
Dove
Dove Medical Press
Subjects:
antimicrobial resistance
Beta lactamases
Care and treatment
Ceftriaxone
Ceftriaxone sodium
Disease transmission
Drug resistance in microorganisms
gonorrhea
neisseria gonorrhoeae
Penicillin G
Practice guidelines (Medicine)
Public health
Review
Safety and security measures
Sexually transmitted diseases
Tetracycline
Tetracyclines
United Kingdom
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Summary:Gonorrhea, a sexually transmitted infection caused by Neisseria gonorrhoeae, is a grave public health concern. Gonorrhea is the second most reported sexually transmitted infection worldwide. The treatment of uncomplicated gonococcal infections has evolved dramatically in response to the emergence of antimicrobial resistance. Multiple resistance mechanisms (for example, beta-lactamase production, antimicrobial efflux, and target site modification) exist, some of which may cause multidrug-resistance. Ceftriaxone was first recommended as an option for uncomplicated gonococcal infections in 1985, and it is now a mainstay of therapy in all clinical practice guidelines. Ceftriaxone has consistently shown high microbiologic cure rates in clinical trials, and it has demonstrated an excellent safety profile. Although its use may be limited in patients with hypersensitivity to penicillins, the risk of using ceftriaxone in such patients is overestimated. The emergence of reduced ceftriaxone susceptibility in N. gonorrhoeae, coupled with a lack of diverse treatment alternatives and the limited pipeline of new antimicrobials, is a significant threat to the treatment of gonorrhea. Keywords: antimicrobial resistance, ceftriaxone, gonorrhea, Neisseria gonorrhoeae
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1179-1365
1179-1365
DOI:10.2147/DHPS.S350763