Search Results - "Morrell, Craig N"

Emerging roles for platelets as immune and inflammatory cells by Morrell, Craig N., Aggrey, Angela A., Chapman, Lesley M., Modjeski, Kristina L.

“…Despite their small size and anucleate status, platelets have diverse roles in vascular biology. Not only are platelets the cellular mediator of thrombosis,…”
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Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions by Yang, Moua, Cooley, Brian C., Li, Wei, Chen, Yiliang, Vasquez-Vivar, Jeannette, Scoggins, Na'il O., Cameron, Scott J., Morrell, Craig N., Silverstein, Roy L.

“…Atherothrombosis is a process mediated by dysregulated platelet activation that can cause life-threatening complications and is the leading cause of death by…”
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The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function by Bennett, J. Allen, Mastrangelo, Michael A., Ture, Sara K., Smith, Charles O., Loelius, Shannon G., Berg, Rachel A., Shi, Xu, Burke, Ryan M., Spinelli, Sherry L., Cameron, Scott J., Carey, Thomas E., Brookes, Paul S., Gerszten, Robert E., Sabater-Lleal, Maria, de Vries, Paul S., Huffman, Jennifer E., Smith, Nicholas L., Morrell, Craig N., Lowenstein, Charles J.

“…Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may…”
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Platelets present antigen in the context of MHC class I by Chapman, Lesley M, Aggrey, Angela A, Field, David J, Srivastava, Kalyan, Ture, Sara, Yui, Katsuyuki, Topham, David J, Baldwin, 3rd, William M, Morrell, Craig N

“…Platelets are most recognized for their vital role as the cellular mediator of thrombosis, but platelets also have important immune functions. Platelets…”
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Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype by Cameron, Scott J, Mix, Doran S, Ture, Sara K, Schmidt, Rachel A, Mohan, Amy, Pariser, Daphne, Stoner, Michael C, Shah, Punit, Chen, Lijun, Zhang, Hui, Field, David J, Modjeski, Kristina L, Toth, Sandra, Morrell, Craig N

“…OBJECTIVE—Reduced blood flow and tissue oxygen tension conditions result from thrombotic and vascular diseases such as myocardial infarction, stroke, and…”
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Platelets as initiators and mediators of inflammation at the vessel wall by Shi, Guanfang, Morrell, Craig N

“…Abstract Platelets are dynamic cells with activities that extend beyond thrombosis including an important role in initiating and sustaining vascular…”
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Commentary on "Desialylated Platelets Maintain Immune Quiescence through Regulating Kupffer Cells" by Li, Chen, Morrell, Craig N

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Associations between ambient wood smoke and other particulate pollutants and biomarkers of systemic inflammation, coagulation and thrombosis in cardiac patients by Croft, Daniel P., Cameron, Scott J., Morrell, Craig N., Lowenstein, Charles J., Ling, Frederick, Zareba, Wojciech, Hopke, Philip K., Utell, Mark J., Thurston, Sally W., Thevenet-Morrison, Kelly, Evans, Kristin A., Chalupa, David, Rich, David Q.

“…Increased particulate air pollution has been associated with both an increased risk of myocardial infarction (MI) and adverse changes in cardiac biomarkers. Up…”
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Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria by Aggrey, Angela A, Srivastava, Kalyan, Ture, Sara, Field, David J, Morrell, Craig N

“…Platelets are most recognized as the cellular mediator of thrombosis, but they are increasingly appreciated for their immunomodulatory roles, including…”
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Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms by Morrell, Craig N, Mix, Doran, Aggarwal, Anu, Bhandari, Rohan, Godwin, Matthew, Owens, 3rd, Phillip, Lyden, Sean P, Doyle, Adam, Krauel, Krystin, Rondina, Matthew T, Mohan, Amy, Lowenstein, Charles J, Shim, Sharon, Stauffer, Shaun, Josyula, Vara Prasad, Ture, Sara K, Yule, David I, Wagner, 3rd, Larry E, Ashton, John M, Elbadawi, Ayman, Cameron, Scott J

“…As blood transitions from steady laminar flow (S-flow) in healthy arteries to disturbed flow (D-flow) in aneurysmal arteries, platelets are subjected to…”
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A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis by Xu, Suowen, Liu, Bin, Yin, Meimei, Koroleva, Marina, Mastrangelo, Michael, Ture, Sara, Morrell, Craig N, Zhang, David X, Fisher, Edward A, Jin, Zheng Gen

“…TRPV4 ion channel mediates vascular mechanosensitivity and vasodilation. Here, we sought to explore whether non-mechanical activation of TRPV4 could limit…”
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Platelet factor 4 mediates vascular smooth muscle cell injury responses by Shi, Guanfang, Field, David J., Long, Xiaochun, Mickelsen, Deanne, Ko, Kyung-ae, Ture, Sara, Korshunov, Vyacheslav A., Miano, Joseph M., Morrell, Craig N.

“…Activated platelets release many inflammatory molecules with important roles in accelerating vascular inflammation. Much is known about platelet and…”
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Axl modulates immune activation of smooth muscle cells in vein graft remodeling by Batchu, Sri N, Xia, Jixiang, Ko, Kyung Ae, Doyley, Marvin M, Abe, Jun-Ichi, Morrell, Craig N, Korshunov, Vyacheslav A

“…The pathophysiological mechanisms of the immune activation of smooth muscle cells are not well understood. Increased expression of Axl, a receptor tyrosine…”
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Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity by Koupenova, Milka, Livada, Alison C., Morrell, Craig N.

“…Classically, platelets have been described as the cellular blood component that mediates hemostasis and thrombosis. This important platelet function has…”
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Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria by Srivastava, Kalyan, Field, David J, Aggrey, Angela, Yamakuchi, Munekazu, Morrell, Craig N

“…Cerebral malaria continues to be a difficult to treat complication of Plasmodium falciparum infection in children. We have shown that platelets can have major…”
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A Novel Anti-Inflammatory Effect for High Density Lipoprotein by Cameron, Scott J, Morrell, Craig N, Bao, Clare, Swaim, AnneMarie F, Rodriguez, Annabelle, Lowenstein, Charles J

“…High density lipoprotein has anti-inflammatory effects in addition to mediating reverse cholesterol transport. While many of the chronic anti-inflammatory…”
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Platelet factor 4 mediates inflammation in experimental cerebral malaria by Srivastava, Kalyan, Cockburn, Ian A, Swaim, AnneMarie, Thompson, Laura E, Tripathi, Abhai, Fletcher, Craig A, Shirk, Erin M, Sun, Henry, Kowalska, M Anna, Fox-Talbot, Karen, Sullivan, David, Zavala, Fidel, Morrell, Craig N

“…Cerebral malaria (CM) is a major complication of Plasmodium falciparum infection in children. The pathogenesis of CM involves vascular inflammation, immune…”
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Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation by Modjeski, Kristina L, Ture, Sara K, Field, David J, Cameron, Scott J, Morrell, Craig N

“…Thrombosis-associated pathologies, such as myocardial infarction and stroke, are major causes of morbidity and mortality worldwide. Because platelets are…”
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Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection by Weber, Emily A, Singh, Meera V, Singh, Vir B, Jackson, Joseph W, Ture, Sara K, Suwunnakorn, Sumanun, Morrell, Craig N, Maggirwar, Sanjay B

“…Background Microvesicles are cell membrane-derived vesicles that have been shown to augment inflammation. Specifically, monocyte-derived microvesicles (MDMVs),…”
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Antibody and Complement in Transplant Vasculopathy by Wehner, Jennifer, Morrell, Craig N, Reynolds, Taylor, Rodriguez, E Rene, Baldwin, William M

“…Advances in immunosuppression have decreased the incidence of acute rejection, but the development of vasculopathy in the coronary arteries of transplants…”
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