Search Results - "Morral, Núria"

Insights from a high-fat diet fed mouse model with a humanized liver by Saxena, Romil, Nassiri, Mehdi, Yin, Xiao-Ming, Morral, Núria

“…Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disorder worldwide and is increasing at an alarming rate. NAFLD is strongly…”
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Impact of silencing hepatic SREBP-1 on insulin signaling by Jideonwo, Victoria, Hou, Yongyong, Ahn, Miwon, Surendran, Sneha, Morral, Núria

“…Sterol Regulatory Element Binding Protein-1 (SREBP-1) is a conserved transcription factor of the basic helix-loop-helix leucine zipper family (bHLH-Zip) that…”
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Aberrant gene expression induced by a high fat diet is linked to H3K9 acetylation in the promoter-proximal region by Morral, Núria, Liu, Sheng, Conteh, Abass M., Chu, Xiaona, Wang, Yue, Dong, X. Charlie, Liu, Yunlong, Linnemann, Amelia K., Wan, Jun

“…Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with an estimated global prevalence of 1 in 4 individuals. Aberrant…”
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Sex- and age-associated factors drive the pathophysiology of MASLD by Yadav, Ajay K, MacNeill, Justin J, Krylov, Aleksei, Ashrafi, Nadia, Mimi, Romana Ashrafi, Saxena, Romil, Liu, Sheng, Graham, Stewart F, Wan, Jun, Morral, Núria

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is strongly associated with obesity. Sex and age affect MASLD prevalence and pathophysiology…”
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Novel targets and therapeutic strategies for type 2 diabetes by Morral, Núria

“…The number of people diagnosed with type 2 diabetes mellitus (T2DM) is increasing at an alarming rate in western societies and has become a major health…”
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Role of non-coding RNAs on liver metabolism and NAFLD pathogenesis by Qian, Gene, Morral, Núria

“…Obesity and type 2 diabetes are major contributors to the growing prevalence of non-alcoholic fatty liver disease (NAFLD), a chronic liver condition…”
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Sterol Regulatory Element-binding Protein-1 (SREBP-1) Is Required to Regulate Glycogen Synthesis and Gluconeogenic Gene Expression in Mouse Liver by Ruiz, Rafaela, Jideonwo, Victoria, Ahn, Miwon, Surendran, Sneha, Tagliabracci, Vincent S., Hou, Yongyong, Gamble, Aisha, Kerner, Janos, Irimia-Dominguez, José M., Puchowicz, Michelle A., DePaoli-Roach, Anna, Hoppel, Charles, Roach, Peter, Morral, Núria

“…Sterol regulatory element-binding protein-1 (SREBP-1) is a key transcription factor that regulates genes in the de novo lipogenesis and glycolysis pathways…”
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Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver by Morral, Núria, Edenberg, Howard J, Witting, Scott R, Altomonte, Jennifer, Chu, Tearina, Brown, Matthew

“…Glucose disposal induces a signal that modulates the transcriptional regulation of genes involved in the glycolysis and lipogenesis pathways. To investigate…”
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Administration of Helper-Dependent Adenoviral Vectors and Sequential Delivery of Different Vector Serotype for Long-Term Liver-Directed Gene Transfer in Baboons by Morral, Núria, O'Neal, Wanda, Rice, Karen, Leland, Michele, Kaplan, Johanne, Piedra, Pedro A., Zhou, Heshan, Parks, Robin J., Velji, Rizwan, Aguilar-Córdova, Estuardo, Wadsworth, Samuel, Graham, Frank L., Kochanek, Stefan, Carey, K. Dee, Beaudet, Arthur L.

“…The efficiency of first-generation adenoviral vectors as gene delivery tools is often limited by the short duration of transgene expression, which can be…”
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Comparative nucleic acid transfection efficacy in primary hepatocytes for gene silencing and functional studies by Park, Jae-Seung, Surendran, Sneha, Kamendulis, Lisa M, Morral, Núria

“…Primary hepatocytes are the best resource for in vitro studies directed at understanding hepatic processes at the cellular and molecular levels, necessary for…”
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Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the livers by Morral, Núria, Edenberg, Howard J., Witting, Scott R., Altomonte, Jennifer, Chu, Tearina, Brown, Matthew

“…Glucose disposal induces a signal that modulates the transcriptional regulation of genes involved in the glycolysis and lipogenesis pathways. To investigate…”
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Gene targets of mouse miR-709: regulation of distinct pools by Surendran, Sneha, Jideonwo, Victoria N., Merchun, Chris, Ahn, Miwon, Murray, John, Ryan, Jennifer, Dunn, Kenneth W., Kota, Janaiah, Morral, Núria

“…MicroRNA (miRNA) are short non-coding RNA molecules that regulate multiple cellular processes, including development, cell differentiation, proliferation and…”
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Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes by Morral, Núria, McEvoy, Robert, Dong, Hengjiang, Meseck, Marcia, Altomonte, Jennifer, Thung, Swan, Woo, Savio L C

“…Glucokinase (GK) plays a crucial role in hepatic glucose disposal. Its activity is decreased in patients with maturity-onset diabetes of the young and in some…”
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Hepatic insulin expression improves glycemic control in type 1 diabetic rats by Dong, Hengjiang, Morral, Núria, McEvoy, Robert, Meseck, Marcia, Thung, Swan N., Woo, Savio L.C.

“…Low levels of hepatic insulin production have been shown to prevent lethal ketoacidosis associated with type 1 diabetes. To assess the beneficial effects of…”
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Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice by Mansouri, Abdelhak, Pacheco-López, Gustavo, Ramachandran, Deepti, Arnold, Myrtha, Leitner, Claudia, Prip-Buus, Carina, Langhans, Wolfgang, Morral, Núria

“…Hepatic fatty acid oxidation (FAO) has long been implicated in the control of eating. Nevertheless, direct evidence for a causal relationship between changes…”
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Insights from a high-fat diet fed mouse model with a humanized liver by Romil Saxena, Mehdi Nassiri, Xiao-Ming Yin, Núria Morral

“…Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disorder worldwide and is increasing at an alarming rate. NAFLD is strongly…”
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Robust hepatic gene silencing for functional studies using helper-dependent adenoviral vectors by Ruiz, Rafaela, Witting, Scott R, Saxena, Romil, Morral, Núria

“…RNA interference is currently envisioned as the basis of gene function and drug target validation studies. This novel technology has the advantage of providing…”
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Vector and helper genome rearrangements occur during production of helper-dependent adenoviral vectors by Ahn, Miwon, Gamble, Aisha, Witting, Scott R, Magrisso, Jack, Surendran, Sneha, Obici, Silvana, Morral, Núria

“…Helper-dependent adenoviral vectors (HD Ad) hold extreme promise for gene therapy of human diseases. All viral genes are deleted in HD Ad vectors, and…”
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Helper-dependent Adenovirus-mediated Short Hairpin RNA Expression in the Liver Activates the Interferon Response by Witting, Scott R., Brown, Matthew, Saxena, Romil, Nabinger, Sarah, Morral, Núria

“…The use of RNA interference has proven to be an effective means to study the function of genes. Constitutive synthesis of small interfering RNA molecules can…”
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Uniparental inheritance of microsatellite alleles of the cystic fibrosis gene (CFTR): identification of a 50 kilobase deletion by Morral, N, Nunes, V, Casals, T, Cobos, N, Asensio, O, Dapena, J, Estivill, X

“…More than 250 mutations have been detected in the cystic fibrosis (CF) transmembrane regulator (CFTR) gene, most of which are single point mutations or small…”
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