Burning mouth syndrome: results of screening tests for vitamin and mineral deficiencies, thyroid hormone, and glucose levels—experience at Mayo Clinic over a decade

Background Burning mouth syndrome (BMS) is a disorder characterized by chronic mouth pain in the absence of objective clinical abnormalities. Vitamin or mineral deficiencies may have a role in BMS, but data regarding the prevalence and relevance of hematinic deficiencies are conflicting. We aimed to...

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Bibliographic Details
Published in:	International journal of dermatology Vol. 56; no. 9; pp. 952 - 956
Main Authors:	Morr Verenzuela, Claudia S., Davis, Mark D. P., Bruce, Alison J., Torgerson, Rochelle R.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-09-2017
Subjects:	Abnormalities Adult Aged Aged, 80 and over Avitaminosis - blood Avitaminosis - complications Blood Blood glucose Blood Glucose - metabolism Burning mouth syndrome Burning Mouth Syndrome - blood Burning Mouth Syndrome - complications Cholecalciferol - blood Cholecalciferol - deficiency Chronic pain Cyanocobalamin Fasting Female Folic acid Folic Acid Deficiency - blood Folic Acid Deficiency - complications Glucose Humans Laboratories Laboratory testing Male Middle Aged Mouth Pain Patients Retrospective Studies Riboflavin Deficiency - blood Riboflavin Deficiency - complications Screening Thiamine Deficiency - blood Thiamine Deficiency - complications Thyroid Thyroid-stimulating hormone Thyrotropin - blood Thyrotropin - deficiency Vitamin B 12 Deficiency - blood Vitamin B 12 Deficiency - complications Vitamin B 6 Deficiency - blood Vitamin B 6 Deficiency - complications Vitamin B1 Vitamin B12 Vitamin B6 Vitamin D Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D3 Young Adult Zinc Zinc - blood Zinc - deficiency
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Summary:	Background Burning mouth syndrome (BMS) is a disorder characterized by chronic mouth pain in the absence of objective clinical abnormalities. Vitamin or mineral deficiencies may have a role in BMS, but data regarding the prevalence and relevance of hematinic deficiencies are conflicting. We aimed to determine the frequency of specific laboratory abnormalities in patients with BMS. Methods We retrospectively reviewed the results of screening blood tests in patients with BMS at our institution between January 2003 and December 2013. Results Among 659 patients with BMS, the most common decreased values or deficiencies were vitamin D3 (15%), vitamin B2 (15%), vitamin B6 (5.7%), zinc (5.7%), vitamin B1 (5.3%), thyrotropin (TSH) (3.2%), vitamin B12 (0.8%), and folic acid (0.7%). Laboratory values for fasting blood glucose and TSH were increased in 23.7% and 5.2%, respectively. Conclusions In patients with symptoms of BMS, our results suggest it is reasonable to screen for fasting blood glucose, vitamin D (D2 and D3), vitamin B6, zinc, vitamin B1, and TSH. Deficiencies of vitamin B12 and folic acid were rare (<1% abnormal).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0011-9059 1365-4632
DOI:	10.1111/ijd.13634