Search Results - "Morphy, John Richard"

Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis by Pupo, Gabriele, Ibba, Francesco, Ascough, David M H, Vicini, Anna Chiara, Ricci, Paolo, Christensen, Kirsten E, Pfeifer, Lukas, Morphy, John Richard, Brown, John M, Paton, Robert S, Gouverneur, Véronique

“…Common anionic nucleophiles such as those derived from inorganic salts have not been used for enantioselective catalysis because of their insolubility. Here,…”
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The dual role of thiourea in the thiotrifluoromethylation of alkenes by Ricci, Paolo, Khotavivattana, Tanatorn, Pfeifer, Lukas, Médebielle, Maurice, Morphy, John Richard, Gouverneur, Véronique

“…Alkenes substituted with a thiourea undergo C-CF followed by intramolecular C-S bond formation with the Togni reagent and trifluoroacetic acid (TFA) at room…”
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The dual role of thiourea in the thiotrifluoromethylation of alkenesElectronic supplementary information (ESI) available. CCDC 1474239-1474241. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc02790c by Ricci, Paolo, Khotavivattana, Tanatorn, Pfeifer, Lukas, Médebielle, Maurice, Morphy, John Richard, Gouverneur, Véronique

“…Alkenes substituted with a thiourea undergo C-CF 3 followed by intramolecular C-S bond formation with the Togni reagent and trifluoroacetic acid (TFA) at room…”
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The dual role of thiourea in the thiotrifluoromethylation of alkenes† †Electronic supplementary information (ESI) available. CCDC 1474239–1474241. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc02790c Click here for additional data file. Click here for additional data file by Ricci, Paolo, Khotavivattana, Tanatorn, Pfeifer, Lukas, Médebielle, Maurice, Morphy, John Richard, Gouverneur, Véronique

“…We report the stereoselective and metal-free trifluoromethylation of alkenes followed by S -cyclization using thiourea as the S-source and SET initiator…”
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ChEMBLSpace--a graphical explorer of the chemogenomic space covered by the ChEMBL database by Fechner, Nikolas, Papadatos, George, Evans, David, Morphy, John Richard, Brewerton, Suzanne Clare, Thorner, David, Bodkin, Michael

“…The ChEMBLSpace graphical explorer enables the identification of compounds from the ChEMBL database, which exhibit a desirable polypharmacology profile. This…”
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