Search Results - "Morphy, J. Richard"

Identification and optimisation of novel sulfonamide, selective vasopressin V₁B receptor antagonists by Baker, James, Bingham, Matilda, Blackburn-Munro, Ruth, Cai, Jiaqiang, Craighead, Mark, Gilfillan, Robert, Goan, Kate, Jaap, David, Milne, Rachel, Richard Morphy, J, Napier, Susan, Presland, Jeremy, Spinks, Gayle, Thomson, Fiona

“…The synthesis and preliminary structure–activity relationships (SAR) of a novel class of vasopressin V₁B receptor antagonists are described. Hit compound 5,…”
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Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide Vasopressin V₁b receptor antagonists by Napier, Susan E, Letourneau, Jeffrey J, Ansari, Nasrin, Auld, Douglas S, Baker, James, Best, Stuart, Campbell-Wan, Leigh, Chan, Ray, Craighead, Mark, Desai, Hema, Ho, Koc-Kan, MacSweeney, Cliona, Milne, Rachel, Richard Morphy, J, Neagu, Irina, Ohlmeyer, Michael H.J, Pick, Jack, Presland, Jeremy, Riviello, Chris, Zanetakos, Heather A, Zhao, Jiuqiao, Webb, Maria L

“…Synthesis and structure–activity relationships (SAR) of a novel series of vasopressin V₁b antagonists are described…”
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Reagent concentration effects in the REM resin solid phase synthesis of tertiary amines by Richard Morphy, J, Rankovic, Zoran, York, Mark

“…The use of reagent concentration has resulted in increased rates for all stages of the REM resin synthesis of tertiary amines. These increases in rate…”
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Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4 H)-yl)acetamide Vasopressin V 1b receptor antagonists by Napier, Susan E., Letourneau, Jeffrey J., Ansari, Nasrin, Auld, Douglas S., Baker, James, Best, Stuart, Campbell-Wan, Leigh, Chan, Ray, Craighead, Mark, Desai, Hema, Ho, Koc-Kan, MacSweeney, Cliona, Milne, Rachel, Richard Morphy, J., Neagu, Irina, Ohlmeyer, Michael H.J., Pick, Jack, Presland, Jeremy, Riviello, Chris, Zanetakos, Heather A., Zhao, Jiuqiao, Webb, Maria L.

“…Synthesis and structure–activity relationships (SAR) of a novel series of vasopressin V 1b antagonists are described…”
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Identification and optimisation of novel sulfonamide, selective vasopressin V 1B receptor antagonists by Baker, James, Bingham, Matilda, Blackburn-Munro, Ruth, Cai, Jiaqiang, Craighead, Mark, Gilfillan, Robert, Goan, Kate, Jaap, David, Milne, Rachel, Richard Morphy, J., Napier, Susan, Presland, Jeremy, Spinks, Gayle, Thomson, Fiona

“…The synthesis and preliminary structure–activity relationships (SAR) of a novel class of vasopressin V 1B receptor antagonists are described. Hit compound 5,…”
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Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist by Brown, Angus R., Bosies, Michael, Cameron, Helen, Clark, John, Cowley, Angela, Craighead, Mark, Elmore, Moira A., Firth, Alistair, Goodwin, Richard, Goutcher, Susan, Grant, Emma, Grassie, Morag, Grove, Simon J.A., Hamilton, Niall M., Hampson, Hannah, Hillier, Alison, Ho, Koc-Kan, Kiczun, Michael, Kingsbury, Celia, Kultgen, Steven G., Littlewood, Peter T.A., Lusher, Scott J., MacDonald, Susan, McIntosh, Lorraine, McIntyre, Theresa, Mistry, Ashvin, Morphy, J. Richard, Nimz, Olaf, Ohlmeyer, Michael, Pick, Jack, Rankovic, Zoran, Sherborne, Brad, Smith, Alasdair, Speake, Michael, Spinks, Gayle, Thomson, Fiona, Watson, Lynn, Weston, Mark

“…High-throughput screening of 3.87million compounds delivered a novel series of non-steroidal GR antagonists. Subsequent rounds of optimisation allowed…”
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Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V₁b receptor antagonists by Napier, Susan E, Letourneau, Jeffrey J, Ansari, Nasrin, Auld, Douglas S, Baker, James, Best, Stuart, Campbell-Wan, Leigh, Chan, Jui-Hsiang, Craighead, Mark, Desai, Hema, Goan, Katharine A, Ho, Koc-Kan, Hulskotte, Ellen G.J, MacSweeney, Cliona P, Milne, Rachel, Morphy, J. Richard, Neagu, Irina, Ohlmeyer, Michael H.J, Peeters, Ard W.M.M, Presland, Jeremy, Riviello, Chris, Ruigt, Ge S.F, Thomson, Fiona J, Zanetakos, Heather A, Zhao, Jiuqiao, Webb, Maria L

“…Synthesis and structure–activity relationships (SAR) of a novel series of vasopressin V₁b (V₃) antagonists are described…”
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Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4 H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists by Letourneau, Jeffrey J., Riviello, Christopher M., Li, Hong, Cole, Andrew G., Ho, Koc-Kan, Zanetakos, Heather A., Desai, Hema, Zhao, Jiuqiao, Auld, Douglas S., Napier, Susan E., Thomson, Fiona J., Goan, Katharine A., Morphy, J. Richard, Ohlmeyer, Michael H.J., Webb, Maria L.

“…The discovery, synthesis, and preliminary structure–activity relationship (SAR) of a novel class of vasopressin V3 (V1b) receptor antagonists is described…”
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Synthesis of Tertiary Amines Using a Polystyrene (REM) Resin by Brown, Angus R, Rees, David C, Rankovic, Zoran, Morphy, J. Richard

“…A range of tertiary amines was constructed using a “traceless” linker on a polystyrene resin (REM resin), starting from secondary amines, primary amines, and…”
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The First Potent and Selective Inhibitors of the Glycine Transporter Type 2 by Caulfield, Wilson L, Collie, Iain T, Dickins, Rachel S, Epemolu, Ola, McGuire, Ross, Hill, David R, McVey, Gillian, Morphy, J. Richard, Rankovic, Zoran, Sundaram, Hardy

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Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters by Barn, David R., Richard Morphy, J., Rees, David C.

“…A new method for the synthesis of amino amides using Wang or Tentagel-PHB resins is described. The method uses aluminium chloride to promote the conversion of…”
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2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors by Ho, Koc-Kan, Appell, Kenneth C., Baldwin, John J., Bohnstedt, Adolph C., Dong, Guizhen, Guo, Tao, Horlick, Robert, Islam, Khondaker R., Kultgen, Steven G., Masterson, Christopher M., McDonald, Edward, McMillan, Kirk, Morphy, J.Richard, Rankovic, Zoran, Sundaram, Hardy, Webb, Maria

“…Structure–activity studies on benzamide 1 obtained from library screening led to the discovery of a novel series of potent and selective glycine transporter…”
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Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists by Palin, Ronald, Barn, David R., Clark, John K., Cottney, Jean E., Cowley, Phillip M., Crockatt, Marc, Evans, Louise, Feilden, Helen, Goodwin, Richard R., Griekspoor, Frank, Grove, Simon J.A., Houghton, Andrea K., Jones, Philip S., Morphy, Richard J., Smith, Alasdair R.C., Sundaram, Hardy, Vrolijk, David, Weston, Mark A., Wishart, Grant, Wren, Paul

“…A series of potent and soluble ORL1 agonists was prepared and evaluated. Compound 41 showed antinociceptive properties in mouse formalin paw test (ED 50 = 1.07…”
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Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4 H)-yl)acetamide vasopressin V 1b receptor antagonists by Napier, Susan E., Letourneau, Jeffrey J., Ansari, Nasrin, Auld, Douglas S., Baker, James, Best, Stuart, Campbell-Wan, Leigh, Chan, Jui-Hsiang, Craighead, Mark, Desai, Hema, Goan, Katharine A., Ho, Koc-Kan, Hulskotte, Ellen G.J., MacSweeney, Cliona P., Milne, Rachel, Morphy, J. Richard, Neagu, Irina, Ohlmeyer, Michael H.J., Peeters, Ard W.M.M., Presland, Jeremy, Riviello, Chris, Ruigt, Ge S.F., Thomson, Fiona J., Zanetakos, Heather A., Zhao, Jiuqiao, Webb, Maria L.

“…Synthesis and structure–activity relationships (SAR) of a novel series of vasopressin V 1b (V 3) antagonists are described. 2-(4-Oxo-2-aryl-quinazolin-3(4…”
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Optimization of Reaction Conditions for REM Resin-Bound Quaternization Reactions by Cameron, Kenneth S, Morphy, J. Richard, Rankovic, Zoran, York, Mark

“…A study into the effect of reaction variables on the quaternization of REM resin-bound tertiary amines was undertaken. The influence of resin matrix, solvent,…”
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A novel linker strategy for solid-phase synthesis by Morphy, J.Richard, Rankovic, Zoran, Rees, David C.

“…The REM resin for solid phase synthesis is described. Its use is illustrated by preparing a small array of tertiary amines using a Hofmann elimination…”
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Solid-Phase Synthesis of Cyclic Imides by Barn, David R, Morphy, J. Richard

“…A cyclative cleavage strategy for the synthesis of cyclic imides on a polystyrene resin is described. After optimization of the cleavage conditions, a small…”
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Low dilution procedures in solid-phase organic synthesis: Diels–Alder and Heck reactions by Morphy, J.Richard, Rankovic, Zoran, York, Mark

“…The use of extremely low solvent volumes (2 μL or less per mg resin) results in significant increases in yield for both the Diels–Alder and Heck reactions on…”
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Fluorocarbon accelerated supported transformations (FAST) on REM resin by Morphy, J.Richard, Rankovic, Zoran, York, Mark

“…The use of perfluorous organic solvents in the solid-phase synthesis of 3° amines on REM resin allows a large reduction in both reaction time and the amount of…”
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Design and Synthesis of a Maximally Diverse and Druglike Screening Library Using REM Resin Methodology by Barn, D, Caulfield, W, Cowley, P, Dickins, R, Bakker, W. Iwema, McGuire, R, Morphy, J. Richard, Rankovic, Z, Thorn, M

“…A 3042 compound screening library was synthesized using a combination of two solid-phase technologies:  REM resin methodology and Lewis acid promoted…”
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