Search Results - "Morozov, Igor Y"

The Colorectal Cancer Microbiota Alter Their Transcriptome To Adapt to the Acidity, Reactive Oxygen Species, and Metabolite Availability of Gut Microenvironments by Lamaudière, Matthew T F, Arasaradnam, Ramesh, Weedall, Gareth D, Morozov, Igor Y

“…The gut microbiome is implicated in the pathology of colorectal cancer (CRC). However, the mechanisms by which the microbiota actively contribute to disease…”
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Transcriptome analysis of the filamentous fungus Aspergillus nidulans directed to the global identification of promoters by Sibthorp, Christopher, Wu, Huihai, Cowley, Gwendolyn, Wong, Prudence W H, Palaima, Paulius, Morozov, Igor Y, Weedall, Gareth D, Caddick, Mark X

“…The filamentous fungus Aspergillus nidulans has been a tractable model organism for cell biology and genetics for over 60 years. It is among a large number of…”
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The Colorectal Cancer Gut Environment Regulates Activity of the Microbiome and Promotes the Multidrug Resistant Phenotype of ESKAPE and Other Pathogens by Lamaudière, Matthew T F, Arasaradnam, Ramesh, Weedall, Gareth D, Morozov, Igor Y

“…Taxonomic composition of the gut microbiota in colorectal cancer (CRC) patients is altered, a newly recognized driving force behind the disease, the activity…”
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Preventive antibiotic treatment of calves: emergence of dysbiosis causing propagation of obese state‐associated and mobile multidrug resistance‐carrying bacteria by Dobrzanska, Dorota A., Lamaudière, Matthew T. F., Rollason, Jessica, Acton, Lauren, Duncan, Michael, Compton, Sharon, Simms, John, Weedall, Gareth D., Morozov, Igor Y.

“…Summary In agriculture, antibiotics are used for the treatment and prevention of livestock disease. Antibiotics perturb the bacterial gut composition but the…”
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mRNA 3′ Tagging Is Induced by Nonsense-Mediated Decay and Promotes Ribosome Dissociation by Morozov, Igor Y., Jones, Meriel G., Gould, Peter D., Crome, Victoria, Wilson, James B., Hall, Anthony J. W., Rigden, Daniel J., Caddick, Mark X.

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Cytoplasmic mRNA 3' tagging in eukaryotes: does it spell the end? by Morozov, Igor Y, Caddick, Mark X

“…Although functional RNA is generally protected against degradation, defects or irregularity during RNA biogenesis lead to rapid degradation. Cellular…”
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CUCU Modification of mRNA Promotes Decapping and Transcript Degradation in Aspergillus nidulans by Morozov, Igor Y., Jones, Meriel G., Razak, Ammar Abdul, Rigden, Daniel J., Caddick, Mark X.

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The bZIP Transcription Factor MeaB Mediates Nitrogen Metabolite Repression at Specific Loci by Wagner, Dominik, Schmeinck, Anne, Mos, Magdalena, Morozov, Igor Y, Caddick, Mark X, Tudzynski, Bettina

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Human gut microbiota and endocrinology: paradigm shift from genome to its regulation by Lamaudière, Matthew T F, Turner, Mark C, Arasaradnam, Ramesh P, Morozov, Igor Y

“…Over the last two decades, it has become clear that the human gut microbiota, a complex community of bacteria, archaea, fungi and viruses, are a critical…”
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Disruption of Dcp1 leads to a Dcp2‐dependent aberrant ribosome profiles in Aspergillus nidulans by Bharudin, Izwan, Caddick, Mark X., Connell, Sean R., Lamaudière, Matthew T. F., Morozov, Igor Y.

“…There are multiple RNA degradation mechanisms in eukaryotes, key among these is mRNA decapping, which requires the Dcp1‐Dcp2 complex. Decapping is involved in…”
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mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells by Singh, Pavneet, James, Rob S., Mee, Christopher J, Morozov, Igor Y.

“…Evidence from yeast and mammals argues the existence of cross-talk between transcription and mRNA decay. Stabilization of transcripts upon depletion of mRNA…”
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Genetic Analysis of the TOR Pathway in Aspergillus nidulans by Fitzgibbon, Gregory J, Morozov, Igor Y, Jones, Meriel G, Caddick, Mark X

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Histone mRNA is subject to 3′ uridylation and re‐adenylation in Aspergillus nidulans by Mossanen‐Parsi, Amir, Parisi, Daniele, Browne‐Marke, Natasha, Bharudin, Izwan, Connell, Sean R., Mayans, Olga, Fucini, Paola, Morozov, Igor Y., Caddick, Mark X.

“…The role of post‐transcriptional RNA modification is of growing interest. One example is the addition of non‐templated uridine residues to the 3′ end of…”
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Nonsense-Mediated mRNA Decay Mutation in Aspergillus nidulans by Morozov, Igor Y, Negrete-Urtasun, Susana, Tilburn, Joan, Jansen, Christine A, Caddick, Mark X, Arst, Jr, Herbert N

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RrmA regulates the stability of specific transcripts in response to both nitrogen source and oxidative stress by Krol, Kinga, Morozov, Igor Y., Jones, Meriel G., Wyszomirski, Tomasz, Weglenski, Piotr, Dzikowska, Agnieszka, Caddick, Mark X.

“…Summary Differential regulation of transcript stability is an effective means by which an organism can modulate gene expression. A well‐characterized example…”
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Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans by Morozov, Igor Y, Jones, Meriel G, Spiller, Dave G, Rigden, Daniel J, Dattenböck, Christoph, Novotny, Rene, Strauss, Joseph, Caddick, Mark X

“…Transcript degradation is a key step in gene regulation. In eukaryotes, mRNA decay is generally initiated by removal of the poly(A) tail mediated by the…”
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Opposing signals differentially regulate transcript stability in Aspergillus nidulans by Caddick, Mark X., Jones, Meriel G., van Tonder, J. Martin, Le Cordier, Hélène, Narendja, Frank, Strauss, Joseph, Morozov, Igor Y.

“…Summary A good model for gene regulation, requiring the organism to monitor a complex and changing environment and respond in a precise and rapid way, is…”
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Characterization of nitrogen metabolite signalling in Aspergillus via the regulated degradation of areA mRNA by Morozov, Igor Y., Galbis‐Martinez, Marisa, Jones, Meriel G., Caddick, Mark X.

“…AreA is the principal transcription factor involved in determining nitrogen utilization in Aspergillus nidulans. NH4+ and Gln are utilized preferentially but…”
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Gene regulation in Aspergillus: From genetics to genomics by Caddick, Mark X., Dobson, Chris, Morozov, Igor Y., Jones, Meriel G.

“…A fundamental aspect of any organism's success is the ability to monitor and respond effectively to its environment, a process which is largely achieved…”
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A defined sequence within the 3′ UTR of the areA transcript is sufficient to mediate nitrogen metabolite signalling via accelerated deadenylation by Morozov, Igor Y., Martinez, Marisa Galbis, Jones, Meriel G., Caddick, Mark X.

“…Nitrogen metabolism in Aspergillus nidulans is regulated by AREA, a member of the GATA family of transcription factors. One mechanism that modulates AREA…”
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