Search Results - "Moroy, Tarik"

GFI1's role in DNA repair suggests implications for tumour cell response to treatment by Vadnais, Charles, Möröy, Tarik

“…Despite recent advances in cancer treatment through personalized and precision medicine and new avenues such as immunotherapy and chimeric antibodies, the…”
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Multifaceted Actions of GFI1 and GFI1B in Hematopoietic Stem Cell Self-Renewal and Lineage Commitment by Beauchemin, Hugues, Möröy, Tarik

“…Growth factor independence 1 (GFI1) and the closely related protein GFI1B are small nuclear proteins that act as DNA binding transcriptional repressors. Both…”
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3026 – GFI1 TETHERS THE NUCLEOSOME-REMODELING AND HISTONE-DEACETYLASE (NURD) COMPLEX TO OPEN AND TRANSCRIPTIONALLY ACTIVE CHROMATIN IN MYELOID PROGENITORS by Moroy, Tarik

“…GFI1 is a SNAG domain-containing zinc finger protein that acts as a transcriptional repressor and controls myeloid differentiation, in particular the…”
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Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications by Möröy, Tarik, Khandanpour, Cyrus

“…Growth factor independence 1 (GFI1) is a DNA binding zinc finger protein, which can mediate transcriptional repression mainly by recruiting histone-modifying…”
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Crosstalk Between MYC and lncRNAs in Hematological Malignancies by Arman, Kaifee, Möröy, Tarik

“…The human genome project revealed the existence of many thousands of long non-coding RNAs (lncRNAs). These transcripts that are over 200 nucleotides long were…”
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Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia by Vassen, Lothar, Khandanpour, Cyrus, Ebeling, Peter, van der Reijden, Bert A., Jansen, Joop H., Mahlmann, Stefan, Dührsen, Ulrich, Möröy, Tarik

“…Gfi1b is a transcriptional repressor that is essential for erythroid cells and megakaryocytes, but is also expressed in hematopoietic stem cells and early…”
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GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1 by Thambyrajah, Roshana, Mazan, Milena, Patel, Rahima, Moignard, Victoria, Stefanska, Monika, Marinopoulou, Elli, Li, Yaoyong, Lancrin, Christophe, Clapes, Thomas, Möröy, Tarik, Robin, Catherine, Miller, Crispin, Cowley, Shaun, Göttgens, Berthold, Kouskoff, Valerie, Lacaud, Georges

“…In vertebrates, the first haematopoietic stem cells (HSCs) with multi-lineage and long-term repopulating potential arise in the AGM (aorta–gonad–mesonephros)…”
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The X-Linked Helicase DDX3X Is Required for Lymphoid Differentiation and MYC-Driven Lymphomagenesis by Lacroix, Marion, Beauchemin, Hugues, Fraszczak, Jennifer, Ross, Julie, Shooshtarizadeh, Peiman, Chen, Riyan, Möröy, Tarik

“…Abstract The X-linked gene DDX3X encodes an RNA helicase that is mutated at high frequencies in several types of human B-cell lymphoma. Females have two active…”
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From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation by Möröy, Tarik, Vassen, Lothar, Wilkes, Brian, Khandanpour, Cyrus

“…The DNA-binding zinc finger transcription factors Gfi1 and Gfi1b were discovered more than 20 years ago and are recognized today as major regulators of both…”
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Growth factor independence 1 (Gfi1) as a regulator of lymphocyte development and activation by Möröy, Tarik, Khandanpour, Cyrus

“…Highlights ► Gfi1 is required for T-cell development. ► Gfi1 is required for B-cell development and restricts Immunoglobulin production. ► Gfi1 promotes Th2…”
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Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes by Shooshtarizadeh, Peiman, Helness, Anne, Vadnais, Charles, Brouwer, Nelleke, Beauchemin, Hugues, Chen, Riyan, Bagci, Halil, Staal, Frank J. T., Coté, Jean-François, Möröy, Tarik

“…Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell…”
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Editorial: New emerging functions of transcription factors and RNA-binding proteins in the development of hematological malignancies by Möröy, Tarik, Khandanpour, Cyrus

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The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphoma by Lacroix, Marion, Beauchemin, Hugues, Khandanpour, Cyrus, Möröy, Tarik

“…DDX3X is an RNA helicase with many functions in RNA metabolism such as mRNA translation, alternative pre-mRNA splicing and mRNA stability, but also plays a…”
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Severe Inflammatory Reactions in Mice Expressing a GFI1P2A Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1) by Fraszczak, Jennifer, Arman, Kaifee Mohammad, Lacroix, Marion, Vadnais, Charles, Gaboury, Louis, Möröy, Tarik

“…Abstract GFI1 is a DNA-binding transcription factor that regulates hematopoiesis by repressing target genes through its association with complexes containing…”
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The transcription factors GFI1 and GFI1B as modulators of the innate and acquired immune response by Fraszczak, Jennifer, Möröy, Tarik

“…GFI1 and GFI1B are small nuclear proteins of 45 and 37kDa, respectively, that have a simple two-domain structure: The first consists of a group of six…”
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The role of the transcriptional repressor growth factor independent 1 in the formation of myeloid cells by Fraszczak, Jennifer, Möröy, Tarik

“…PURPOSE OF REVIEWGrowth factor independent 1 (Gfi1) is a transcriptional repressor that plays multiple roles during myeloid commitment and development…”
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Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation by Subramani, Poorani Ganesh, Fraszczak, Jennifer, Helness, Anne, Estall, Jennifer L, Möröy, Tarik, Di Noia, Javier M

“…The multifunctional RNA-binding protein hnRNPL is implicated in antibody class switching but its broader function in B cells is unknown. Here, we show that…”
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GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1 by Vadnais, Charles, Chen, Riyan, Fraszczak, Jennifer, Yu, Zhenbao, Boulais, Jonathan, Pinder, Jordan, Frank, Daria, Khandanpour, Cyrus, Hébert, Josée, Dellaire, Graham, Côté, Jean-François, Richard, Stéphane, Orthwein, Alexandre, Drobetsky, Elliot, Möröy, Tarik

“…GFI1 is a transcriptional regulator expressed in lymphoid cells, and an “oncorequisite” factor required for development and maintenance of T-lymphoid leukemia…”
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Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice by Fraszczak, Jennifer, Vadnais, Charles, Rashkovan, Marissa, Ross, Julie, Beauchemin, Hugues, Chen, Riyan, Grapton, Damien, Khandanpour, Cyrus, Möröy, Tarik

“…Growth factor independent 1 (Gfi1) controls myeloid differentiation by regulating gene expression and limits the activation of p53 by facilitating its…”
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Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models by Ross, Julie, Rashkovan, Marissa, Fraszczak, Jennifer, Joly-Beauparlant, Charles, Vadnais, Charles, Winkler, René, Droit, Arnaud, Kosan, Christian, Möröy, Tarik

“…Acute lymphoblastic leukemia (ALL) is an aggressive blood cancer that mainly affects children. Relapse rates are high and toxic chemotherapies that block DNA…”
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