Search Results - "Morota, Saori"

Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency by Ehinger, Johannes K., Piel, Sarah, Ford, Rhonan, Karlsson, Michael, Sjövall, Fredrik, Frostner, Eleonor Åsander, Morota, Saori, Taylor, Robert W., Turnbull, Doug M., Cornell, Clive, Moss, Steven J., Metzsch, Carsten, Hansson, Magnus J., Fliri, Hans, Elmér, Eskil

“…Mitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of…”
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Mitochondrial dysfunction in blood cells from amyotrophic lateral sclerosis patients by Ehinger, Johannes K., Morota, Saori, Hansson, Magnus J., Paul, Gesine, Elmér, Eskil

“…Mitochondrial dysfunction is implicated in amyotrophic lateral sclerosis, where the progressive degeneration of motor neurons results in muscle atrophy,…”
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Mitochondrial respiration in human viable platelets--methodology and influence of gender, age and storage by Sjövall, Fredrik, Ehinger, Johannes K H, Marelsson, Sigurður E, Morota, Saori, Frostner, Eleonor Asander, Uchino, Hiroyuki, Lundgren, Johan, Arnbjörnsson, Einar, Hansson, Magnus J, Fellman, Vineta, Elmér, Eskil

“…Studying whole cell preparations with intact mitochondria and respiratory complexes has a clear benefit compared to isolated or disrupted mitochondria due to…”
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Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition by Hansson, Magnus J., Månsson, Roland, Morota, Saori, Uchino, Hiroyuki, Kallur, Thérese, Sumi, Tetsuo, Ishii, Nagao, Shimazu, Motohide, Keep, Marcus F., Jegorov, Alexandr, Elmér, Eskil

“…Mitochondrial uptake of calcium in excitotoxicity is associated with subsequent increase in reactive oxygen species (ROS) generation and delayed cellular…”
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miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro by Ishikawa, Mitsuru, Aoyama, Takeshi, Shibata, Shoichiro, Sone, Takefumi, Miyoshi, Hiroyuki, Watanabe, Hirotaka, Nakamura, Mari, Morota, Saori, Uchino, Hiroyuki, Yoo, Andrew S, Okano, Hideyuki

“…Obtaining differentiated cells with high physiological functions by an efficient, but simple and rapid differentiation method is crucial for modeling neuronal…”
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Cytokine and nitric oxide levels in patients with sepsis--temporal evolvement and relation to platelet mitochondrial respiratory function by Sjövall, Fredrik, Morota, Saori, Asander Frostner, Eleonor, Hansson, Magnus J, Elmér, Eskil

“…The levels of nitric oxide (NO) and various cytokines are known to be increased during sepsis. These signaling molecules could potentially act as regulators…”
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Increased Potassium Conductance of Brain Mitochondria Induces Resistance to Permeability Transition by Enhancing Matrix Volume by Hansson, Magnus J., Morota, Saori, Teilum, Maria, Mattiasson, Gustav, Uchino, Hiroyuki, Elmér, Eskil

“…Modulation of K+ conductance of the inner mitochondrial membrane has been proposed to mediate preconditioning in ischemia-reperfusion injury. The mechanism is…”
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Cytokine and nitric oxide levels in patients with sepsis--temporal evolvement and relation to platelet mitochondrial respiratory function by Sjövall, Fredrik, Morota, Saori, Frostner, Eleonor Åsander, Hansson, Magnus J, Elmér, Eskil

“…The levels of nitric oxide (NO) and various cytokines are known to be increased during sepsis. These signaling molecules could potentially act as regulators…”
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Functional and pharmacological characteristics of permeability transition in isolated human heart mitochondria by Morota, Saori, Manolopoulos, Theodor, Eyjolfsson, Atli, Kimblad, Per-Ola, Wierup, Per, Metzsch, Carsten, Blomquist, Sten, Hansson, Magnus J

“…The objective of the present study was to validate the presence and explore the characteristics of mitochondrial permeability transition (mPT) in isolated…”
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Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria by Hansson, Magnus J, Morota, Saori, Chen, Li, Matsuyama, Nagahisa, Suzuki, Yoshiaki, Nakajima, Satoshi, Tanoue, Tadashi, Omi, Akibumi, Shibasaki, Futoshi, Shimazu, Motohide, Ikeda, Yukio, Uchino, Hiroyuki, Elmér, Eskil

“…The mitochondrial permeability transition (mPT) is considered to be a major cause of cell death under a variety of pathophysiological conditions of the central…”
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Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders — Specificity vs. toxicity by Morota, Saori, Månsson, Roland, Hansson, Magnus J., Kasuya, Kazuhiko, Shimazu, Motohide, Hasegawa, Erika, Yanagi, Shigeru, Omi, Akibumi, Uchino, Hiroyuki, Elmér, Eskil

“…Inhibition of mitochondrial permeability transition (mPT) has emerged as a promising approach for neuroprotection and development of well-tolerated mPT…”
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Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline by Månsson, Roland, Hansson, Magnus J, Morota, Saori, Uchino, Hiroyuki, Ekdahl, Christine T, Elmér, Eskil

“…Abstract Minocycline has been shown to be neuroprotective in ischemic and neurodegenerative disease models and could potentially be relevant for clinical use…”
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Cyclophilin-D inhibition in neuroprotection: dawn of a new era of mitochondrial medicine by Uchino, Hiroyuki, Hatakeyama, Kiyoshi, Morota, Saori, Tanoue, Tadashi, Nishiyama, Takahisa, Usui, Daiki, Taguchi, Chisato, Suzuki, Morika, Hansson, Magnus J, Elmér, Eskil

“…Traumatic brain injury and ischemia can result in marked neuronal degeneration and residual impairment of cerebral function. However, no effective…”
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Minocycline sensitizes rodent and human liver mitochondria to the permeability transition: Implications for toxicity in liver transplantation by Månsson, Roland, Morota, Saori, Hansson, Magnus J., Sonoda, Ichiro, Yasuda, Yoshihiro, Shimazu, Motohide, Sugiura, Ayumu, Yanagi, Shigeru, Miura, Hitoshi, Uchino, Hiroyuki, Elmér, Eskil

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Probing the molecular mechanisms of neuronal degeneration: importance of mitochondrial dysfunction and calcineurin activation by Uchino, Hiroyuki, Kuroda, Yasuhiro, Morota, Saori, Hirabayashi, Go, Ishii, Nagao, Shibasaki, Futoshi, Ikeda, Yukiho, Hansson, Magnus J., Elmér, Eskil

“…Cerebral injury is a critical aspect of the management of patients in intensive care. Pathological conditions induced by cerebral ischemia, hypoxia, head…”
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Patients with sepsis exhibit increased mitochondrial respiratory capacity in peripheral blood immune cells by Sjövall, Fredrik, Morota, Saori, Persson, Johan, Hansson, Magnus J, Elmér, Eskil

“…In sepsis, mitochondria have been associated with both initial dysfunction and subsequent upregulation (biogenesis). However, the evolvement of mitochondrial…”
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Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis by Sjövall, Fredrik, Morota, Saori, Hansson, Magnus J, Friberg, Hans, Gnaiger, Erich, Elmér, Eskil

“…Mitochondrial dysfunction has been suggested as a contributing factor to the pathogenesis of sepsis-induced multiple organ failure. Also, restoration of…”
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The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β by Fujita, Hidetoshi, Yagishita, Naoko, Aratani, Satoko, Saito-Fujita, Tomoko, Morota, Saori, Yamano, Yoshihisa, Hansson, Magnus J, Inazu, Masato, Kokuba, Hiroko, Sudo, Katsuko, Sato, Eiichi, Kawahara, Ko-ichi, Nakajima, Fukami, Hasegawa, Daisuke, Higuchi, Itsuro, Sato, Tomoo, Araya, Natsumi, Usui, Chie, Nishioka, Kenya, Nakatani, Yu, Maruyama, Ikuro, Usui, Masahiko, Hara, Naomi, Uchino, Hiroyuki, Elmer, Eskil, Nishioka, Kusuki, Nakajima, Toshihiro

“…Obesity is a major global public health problem, and understanding its pathogenesis is critical for identifying a cure. In this study, a gene knockout strategy…”
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Molecular mechanism of ischemic brain injuries and perspectives of drug therapies for neuroprotection by Uchino, Hiroyuki, Morota, Saori, Hirabayashi, Go, Ushijima, Kazuo, Kakinuma, Takayasu, Ishii, Nagao, Shibasaki, Futoshi, Kuroda, Yasuhiro

“…Ischemic brain injury is a critical condition in the management of patients during anesthesia and intensive care. It is not rare that pathological conditions…”
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Oxygen consumption in platelets as an adjunct diagnostic method for pediatric mitochondrial disease by Westerlund, Emil, Marelsson, Sigurður E, Ehinger, Johannes K, Sjövall, Fredrik, Morota, Saori, Åsander Frostner, Eleonor, Oldfors, Anders, Darin, Niklas, Lundgren, Johan, Hansson, Magnus J, Fellman, Vineta, Elmér, Eskil

“…Background Diagnosing mitochondrial disease (MD) is a challenge. In addition to genetic analyses, clinical practice is to perform invasive procedures such as…”
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