Search Results - "Morokuma, Junji"

Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous Bioelectric Gradients by Durant, Fallon, Morokuma, Junji, Fields, Christopher, Williams, Katherine, Adams, Dany Spencer, Levin, Michael

“…We show that regenerating planarians’ normal anterior-posterior pattern can be permanently rewritten by a brief perturbation of endogenous bioelectrical…”
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Neural control of body-plan axis in regenerating planaria by Pietak, Alexis, Bischof, Johanna, LaPalme, Joshua, Morokuma, Junji, Levin, Michael

“…Control of axial polarity during regeneration is a crucial open question. We developed a quantitative model of regenerating planaria, which elucidates…”
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Gap Junctional Blockade Stochastically Induces Different Species-Specific Head Anatomies in Genetically Wild-Type Girardia dorotocephala Flatworms by Emmons-Bell, Maya, Durant, Fallon, Hammelman, Jennifer, Bessonov, Nicholas, Volpert, Vitaly, Morokuma, Junji, Pinet, Kaylinnette, Adams, Dany S, Pietak, Alexis, Lobo, Daniel, Levin, Michael

“…The shape of an animal body plan is constructed from protein components encoded by the genome. However, bioelectric networks composed of many cell types have…”
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Interleukin-1β activates matrix metalloproteinase-2 to alter lacrimal gland myoepithelial cell structure and function by Morokuma, Junji, Gárriz, Angela, Toribio, Danny, Pagni, Sarah, Zoukhri, Driss

“…The aim of the present study is to investigate the role of c-Jun N-terminal kinase (JNK) and matrix metalloproteinase-2 (MMP-2) in mediating the effects of…”
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Effects of Proinflammatory Cytokines on Lacrimal Gland Myoepithelial Cells Contraction by Garriz, Angela, Morokuma, Junji, Bowman, Maytal, Pagni, Sarah, Zoukhri, Driss

“…In the lacrimal gland, myoepithelial cells (MEC) express muscle contractile proteins such as alpha smooth muscle actin (SMA) and calponin and therefore can…”
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Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells by Morokuma, Junji, Blackiston, Douglas, Adams, Dany S, Seebohm, Guiscard, Trimmer, Barry, Levin, Michael

“…Ion transporters, and the resulting voltage gradients and electric fields, have been implicated in embryonic development and regeneration. These biophysical…”
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Regenerative Adaptation to Electrochemical Perturbation in Planaria: A Molecular Analysis of Physiological Plasticity by Emmons-Bell, Maya, Durant, Fallon, Tung, Angela, Pietak, Alexis, Miller, Kelsie, Kane, Anna, Martyniuk, Christopher J., Davidian, Devon, Morokuma, Junji, Levin, Michael

“…Anatomical homeostasis results from dynamic interactions between gene expression, physiology, and the external environment. Owing to its complexity, this…”
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KCNQ1 and KCNE1 K+ Channel Components are Involved in Early Left-Right Patterning in Xenopus laevis Embryos by Morokuma, Junji, Blackiston, Douglas, Levin, Michael

“…Several ion transporters have been implicated in left-right (LR) patterning. Here, we characterize a new component of the early bioelectrical circuit: the…”
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HrNodal, the ascidian nodal-related gene, is expressed in the left side of the epidermis, and lies upstream of HrPitx by Morokuma, Junji, Ueno, Motoko, Kawanishi, Hiroshi, Saiga, Hidetoshi, Nishida, Hiroki

“…The nodal-related genes are well known for their fundamental roles during vertebrate development, including mesoderm induction, neural induction, and…”
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The Role of Early Bioelectric Signals in the Regeneration of Planarian Anterior/Posterior Polarity by Durant, Fallon, Bischof, Johanna, Fields, Chris, Morokuma, Junji, LaPalme, Joshua, Hoi, Alison, Levin, Michael

“…Axial patterning during planarian regeneration relies on a transcriptional circuit that confers distinct positional information on the two ends of an amputated…”
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Role of the adenylate cyclase/cyclic AMP pathway in oxytocin-induced lacrimal gland myoepithelial cells contraction by Gárriz, Angela, Morokuma, Junji, Toribio, Danny, Zoukhri, Driss

“…The aim of these studies was to investigate the involvement of the second messenger 3′,5′-cyclic adenosine monophosphate (cAMP) and its downstream effectors in…”
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A Chemical Genetics Approach Reveals H,K-ATPase-Mediated Membrane Voltage Is Required for Planarian Head Regeneration by Beane, Wendy S., Morokuma, Junji, Adams, Dany S., Levin, Michael

“…Biophysical signaling is required for both embryonic polarity and regenerative outgrowth. Exploiting endogenous ion transport for regenerative therapies will…”
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Computational discovery and in vivo validation of hnf4 as a regulatory gene in planarian regeneration by Lobo, Daniel, Morokuma, Junji, Levin, Michael

“…Automated computational methods can infer dynamic regulatory network models directly from temporal and spatial experimental data, such as genetic perturbations…”
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Bioelectric signaling regulates head and organ size during planarian regeneration by Beane, Wendy Scott, Morokuma, Junji, Lemire, Joan M, Levin, Michael

“…A main goal of regenerative medicine is to replace lost or damaged tissues and organs with functional parts of the correct size and shape. But the…”
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Role of the Phospholipase C Pathway and Calcium Mobilization in Oxytocin-Induced Contraction of Lacrimal Gland Myoepithelial Cells by Gárriz, Angela, Aubry, Salome, Wattiaux, Quentin, Bair, Jeffrey, Mariano, Michael, Hatzipetrou, Georgios, Bowman, Maytal, Morokuma, Junji, Ortiz, Gustavo, Hamrah, Pedram, Dartt, Darlene A, Zoukhri, Driss

“…We reported that oxytocin (OXT), added to freshly prepared lacrimal gland lobules, induced myoepithelial cell (MEC) contraction. In other systems, OXT…”
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Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration by Oviedo, Néstor J., Morokuma, Junji, Walentek, Peter, Kema, Ido P., Gu, Man Bock, Ahn, Joo-Myung, Hwang, Jung Shan, Gojobori, Takashi, Levin, Michael

“…Having the ability to coordinate the behavior of stem cells to induce regeneration of specific large-scale structures would have far-reaching consequences in…”
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TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis by Ogata, Souichi, Morokuma, Junji, Hayata, Tadayoshi, Kolle, Gabriel, Niehrs, Christof, Ueno, Naoto, Cho, Ken W Y

“…The molecular mechanisms governing the cell behaviors underlying morphogenesis remain a major focus of research in both developmental biology and cancer…”
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Space travel has effects on planarian regeneration that cannot be explained by a null hypothesis by Levin, Michael, Morokuma, Junji, Finkelstein, Joshua

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Live imaging of intracellular pH in planarians using the ratiometric fluorescent dye SNARF-5F-AM by Beane, Wendy Scott, Adams, Dany Spencer, Morokuma, Junji, Levin, Michael

“…Physiological parameters such as resting potential and pH are increasingly recognized as important regulators of cell activity and tissue-level events in…”
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H,K-ATPase-mediated ion transport regulates anterior patterning in regenerating planaria by Beane, Wendy S., Morokuma, Junji, Levin, Mike

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