Gastroprotective effect of Berberis vulgaris on ethanol-induced gastric mucosal injury: Histopathological evaluations

Modern treatment of peptic ulcers includes antibacterial and gastroprotective medications. However, current anti-ulcer drugs possess severe side effects. Therefore, all attempts to find new effective medications free from side effects are justified. Though is a medicinal plant commonly used for the...

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Bibliographic Details
Published in:	Avicenna journal of phytomedicine Vol. 12; no. 1; pp. 30 - 41
Main Authors:	Kapitonova, Marina, Gupalo, Sergey, Alyautdin, Renad, Ibrahim, Ibrahim Abdel Aziz, Salim, Norita, Ahmad, Azhar, Talip, Saiful Bahri, Nwe, Tin Moe, Morokhina, Svetlana
Format:	Journal Article
Language:	English
Published:	Iran Mashhad University of Medical Sciences 01-01-2022
Subjects:	berberis vulgaris Original prostaglandin e2 stomach ulcer Prostaglandin E2 Stomach ulcer Berberis vulgaris
Online Access:	Get full text
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Summary:	Modern treatment of peptic ulcers includes antibacterial and gastroprotective medications. However, current anti-ulcer drugs possess severe side effects. Therefore, all attempts to find new effective medications free from side effects are justified. Though is a medicinal plant commonly used for the treatment of numerous disorders, gastroprotective effect of its leaf extract was not investigated before. Gastric ulcer was modelled in Sprague-Dawley rats after treatment with leaf extract containing 0.07% of alkaloids, 0.48% of flavonoids and 8.05% of tanning substances, 10 or 50 mg of dry extract/kg, changes in the stomach mucosa were assessed semi-quantitatively, and the gastric wall was evaluated for prostaglandin E2 level using ELISA and assessed histologically by calculation of the lesion index. leaf extract at the dose of 50 mg/kg reduced the macroscopic ulcer score and the microscopic lesion index, increased prostaglandin E2 concentration in the gastric wall significantly higher than atropine and leaf extract 10 mg/kg. The gastroprotective effect of the high dose of leaf extract may be due to stimulation of prostaglandin E2 secretion in the stomach, and anti-oxidative and anti-inflammatory properties of polyphenolic complex of flavonoids and tannins present in the leaves of this plant.
ISSN:	2228-7930 2228-7949
DOI:	10.22038/AJP.2021.18113