Search Results - "Moroi, Syoko"

Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses by Khawaja, Anthony P, Cooke Bailey, Jessica N, Kang, Jae Hee, Allingham, R Rand, Hauser, Michael A, Brilliant, Murray, Budenz, Donald L, Christen, William G, Fingert, John, Gaasterland, Douglas, Gaasterland, Terry, Kraft, Peter, Lee, Richard K, Lichter, Paul R, Liu, Yutao, Medeiros, Felipe, Moroi, Syoko E, Richards, Julia E, Realini, Tony, Ritch, Robert, Schuman, Joel S, Scott, William K, Singh, Kuldev, Sit, Arthur J, Vollrath, Douglas, Wollstein, Gadi, Zack, Donald J, Zhang, Kang, Pericak-Vance, Margaret, Weinreb, Robert N, Haines, Jonathan L, Pasquale, Louis R, Wiggs, Janey L

“…Recent studies indicate that mitochondrial proteins may contribute to the pathogenesis of primary open-angle glaucoma (POAG). In this study, we examined the…”
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Mitochondrial TXNRD2 and ME3 Genetic Risk Scores Are Associated with Specific Primary Open-Angle Glaucoma Phenotypes by Aboobakar, Inas F., Kinzy, Tyler G., Zhao, Yan, Fan, Baojian, Pasquale, Louis R., Qassim, Ayub, Kolovos, Antonia, Schmidt, Joshua M., Craig, Jamie E., Cooke Bailey, Jessica N., Wiggs, Janey L., Allingham, R. Rand, Brilliant, Murray, Budenz, Donald L., Cooke Bailey, Jessica N., Fingert, John H., Gaasterland, Douglas, Gaasterland, Teresa, Haines, Jonathan L., Hauser, Michael A., Lee, Richard K., Lichter, Paul R., Liu, Yutao, Moroi, Syoko, Myers, Jonathan, Pasquale, Louis R., Pericak-Vance, Margaret, Realini, Anthony, Rhee, Doug, Richards, Julia E., Ritch, Robert, Schuman, Joel S., Scott, William K., Singh, Kuldev, Sit, Arthur J., Vollrath, Douglas, Weinreb, Robert N., Wiggs, Janey L., Wollstein, Gadi, Zack, Donald J.

“…Genetic variants in regions that include the mitochondrial genes thioredoxin reductase 2 (TXNRD2) and malic enzyme 3 (ME3) are associated with primary…”
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Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma by Liu, Wendy W., Kinzy, Tyler G., Cooke Bailey, Jessica N., Xu, Zihe, Hysi, Pirro, Wiggs, Janey L.

“…Although glaucoma is a disease modulated by eye pressure, the mechanisms of pressure sensing in the eye are not well understood. Here, we investigated…”
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Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility by Chintalapudi, Sumana R., Maria, Doaa, Di Wang, Xiang, Bailey, Jessica N. Cooke, Hysi, Pirro G., Wiggs, Janey L., Williams, Robert W., Jablonski, Monica M.

“…Glaucoma is a multi-factorial blinding disease in which genetic factors play an important role. Elevated intraocular pressure is a highly heritable risk factor…”
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Myocilin Mutations in Patients With Normal-Tension Glaucoma by Alward, Wallace L M, van der Heide, Carly, Khanna, Cheryl L, Roos, Ben R, Sivaprasad, Sobha, Kam, Jason, Ritch, Robert, Lotery, Andrew, Igo, Jr, Robert P, Cooke Bailey, Jessica N, Stone, Edwin M, Scheetz, Todd E, Kwon, Young H, Pasquale, Louis R, Wiggs, Janey L, Fingert, John H

“…Mutations in the myocilin (MYOC) gene are the most common molecularly defined cause of primary open-angle glaucoma that typically occurs in patients with high…”
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Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma by King, Rebecca, Struebing, Felix L, Li, Ying, Wang, Jiaxing, Koch, Allison Ashley, Cooke Bailey, Jessica N, Gharahkhani, Puya, MacGregor, Stuart, Allingham, R Rand, Hauser, Michael A, Wiggs, Janey L, Geisert, Eldon E

“…Central corneal thickness (CCT) is one of the most heritable ocular traits and it is also a phenotypic risk factor for primary open angle glaucoma (POAG). The…”
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Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma by Gharahkhani, Puya, Burdon, Kathryn P., Cooke Bailey, Jessica N., Hewitt, Alex W., Law, Matthew H., Pasquale, Louis R., Kang, Jae H., Haines, Jonathan L., Souzeau, Emmanuelle, Zhou, Tiger, Siggs, Owen M., Landers, John, Awadalla, Mona, Sharma, Shiwani, Mills, Richard A., Ridge, Bronwyn, Lynn, David, Casson, Robert, Graham, Stuart L., Goldberg, Ivan, White, Andrew, Healey, Paul R., Grigg, John, Lawlor, Mitchell, Mitchell, Paul, Ruddle, Jonathan, Coote, Michael, Walland, Mark, Best, Stephen, Vincent, Andrea, Gale, Jesse, RadfordSmith, Graham, Whiteman, David C., Montgomery, Grant W., Martin, Nicholas G., Mackey, David A, Wiggs, Janey L., MacGregor, Stuart, Craig, Jamie E.

“…Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG…”
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Family-Based Genome-Wide Association Study of South Indian Pedigrees Supports WNT7B as a Central Corneal Thickness Locus by Fan, Bao Jian, Chen, Xueli, Sondhi, Nisha, Sharmila, P Ferdinamarie, Soumittra, Nagasamy, Sripriya, Sarangapani, Sacikala, Srinivasan, Asokan, Rashima, Friedman, David S, Pasquale, Louis R, Gao, X Raymond, Vijaya, Lingam, Cooke Bailey, Jessica, Vitart, Veronique, MacGregor, Stuart, Hammond, Christopher J, Khor, Chiea Chuen, Haines, Jonathan L, George, Ronnie, Wiggs, Janey L

“…To identify genetic risk factors contributing to central corneal thickness (CCT) in individuals from South India, a population with a high prevalence of ocular…”
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Multi-trait genome-wide association study identifies new loci associated with optic disc parameters by Bonnemaijer, Pieter W. M., Leeuwen, Elisabeth M. van, Iglesias, Adriana I., Gharahkhani, Puya, Vitart, Veronique, Khawaja, Anthony P., Simcoe, Mark, Höhn, René, Cree, Angela J., Igo, Rob P., Gerhold-Ay, Aslihan, Nickels, Stefan, Wilson, James F., Hayward, Caroline, Boutin, Thibaud S., Polašek, Ozren, Aung, Tin, Khor, Chiea Chuen, Amin, Najaf, Lotery, Andrew J., Wiggs, Janey L., Cheng, Ching-Yu, Hysi, Pirro G., Hammond, Christopher J., Thiadens, Alberta A. H. J., MacGregor, Stuart, Klaver, Caroline C. W., Duijn, Cornelia M. van

“…A new avenue of mining published genome-wide association studies includes the joint analysis of related traits. The power of this approach depends on the…”
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