Search Results - "Moro, Loredana"

Mitochondrial DNA and MitomiR Variations in Pancreatic Cancer: Potential Diagnostic and Prognostic Biomarkers by Moro, Loredana

“…Pancreatic cancer is an aggressive disease with poor prognosis. Only about 15–20% of patients diagnosed with pancreatic cancer can undergo surgical resection,…”
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The Mitochondrial Proteome of Tumor Cells: A SnapShot on Methodological Approaches and New Biomarkers by Moro, Loredana

“…Mitochondria are highly dynamic and regulated organelles implicated in a variety of important functions in the cell, including energy production, fatty acid…”
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Mitochondria Can Cross Cell Boundaries: An Overview of the Biological Relevance, Pathophysiological Implications and Therapeutic Perspectives of Intercellular Mitochondrial Transfer by Valenti, Daniela, Vacca, Rosa Anna, Moro, Loredana, Atlante, Anna

“…Mitochondria are complex intracellular organelles traditionally identified as the powerhouses of eukaryotic cells due to their central role in bioenergetic…”
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The mitochondrial genome encodes abundant small noncoding RNAs by Ro, Seungil, Ma, Hsiu-Yen, Park, Chanjae, Ortogero, Nicole, Song, Rui, Hennig, Grant W, Zheng, Huili, Lin, Yung-Ming, Moro, Loredana, Hsieh, Jer-Tsong, Yan, Wei

“…Small noncoding RNAs identified thus far are all encoded by the nuclear genome. Here, we report that the murine and human mitochondrial genomes encode…”
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Programmed Cell Death in Health and Disease by Gibellini, Lara, Moro, Loredana

“…Programmed cell death is a conserved evolutionary process of cell suicide that is central to the development and integrity of eukaryotic organisms [...]…”
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Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer by Guerra, Flora, Guaragnella, Nicoletta, Arbini, Arnaldo A, Bucci, Cecilia, Giannattasio, Sergio, Moro, Loredana

“…Epithelial-to-mesenchymal transition (EMT) allows epithelial cancer cells to assume mesenchymal features, endowing them with enhanced motility and…”
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Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis by Moro, Loredana, Simoneschi, Daniele, Kurz, Emma, Arbini, Arnaldo A., Jang, Shaowen, Guaragnella, Nicoletta, Giannattasio, Sergio, Wang, Wei, Chen, Yu-An, Pires, Geoffrey, Dang, Andrew, Hernandez, Elizabeth, Kapur, Payal, Mishra, Ankita, Tsirigos, Aristotelis, Miller, George, Hsieh, Jer-Tsong, Pagano, Michele

“…Epigenetic plasticity is a pivotal factor that drives metastasis. Here, we show that the promoter of the gene that encodes the ubiquitin ligase subunit FBXL7…”
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Prostate cancer cells metabolize d-lactate inside mitochondria via a d-lactate dehydrogenase which is more active and highly expressed than in normal cells by de Bari, Lidia, Moro, Loredana, Passarella, Salvatore

“…► First evidence is given that cancer cells metabolize d-lactate inside mitochondria. ► d-Lactate dehydrogenase (d-LDH) is shown to be present in prostate…”
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Epigenetic suppression of FBXL7 promotes metastasis by Moro, Loredana, Pagano, Michele

“…Epigenetic reprogramming is emerging as a key mechanism for metastasis development. Our study identified a novel regulatory mechanism whereby promoter…”
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Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis by Duan, Shanshan, Moro, Loredana, Qu, Rui, Simoneschi, Daniele, Cho, Hyunwoo, Jiang, Shaowen, Zhao, Huiyong, Chang, Qing, de Stanchina, Elisa, Arbini, Arnaldo A., Pagano, Michele

“…FBXO31 is the substrate receptor of one of many CUL1-RING ubiquitin ligase (CRL1) complexes. Here, we show that low FBXO31 mRNA levels are associated with high…”
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Integrin-Linked Kinase Links Integrin Activation to Invadopodia Function and Invasion via the p(T567)-Ezrin/NHERF1/NHE1 Pathway by Greco, Maria Raffaella, Moro, Loredana, Forciniti, Stefania, Alfarouk, Khalid, Cannone, Stefania, Cardone, Rosa Angela, Reshkin, Stephan Joel

“…Tumor cell invasion depends largely on degradation of the extracellular matrix (ECM) by protease-rich structures called invadopodia, whose formation and…”
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Author Correction: The mitochondrial genome encodes abundant small noncoding RNAs by Ro, Seungil, Ma, Hsiu-Yen, Park, Chanjae, Ortogero, Nicole, Song, Rui, Hennig, Grant W., Zheng, Huili, Lin, Yung-Ming, Moro, Loredana, Hsieh, Jer-Tsong, Yan, Wei

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Extracellular Vesicles and Pancreatic Cancer: Insights on the Roles of miRNA, lncRNA, and Protein Cargos in Cancer Progression by Romano, Roberta, Picca, Anna, Eusebi, Leonardo Henry Umberto, Marzetti, Emanuele, Calvani, Riccardo, Moro, Loredana, Bucci, Cecilia, Guerra, Flora

“…Pancreatic cancer (PC) is among the most devastating digestive tract cancers worldwide. This cancer is characterized by poor diagnostic detection, lack of…”
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ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion by Antelmi, Ester, Cardone, Rosa A, Greco, Maria R, Rubino, Rosa, Di Sole, Francesca, Martino, Nicola A, Casavola, Valeria, Carcangiu, Marialuisa, Moro, Loredana, Reshkin, Stephan J

“…Extracellular matrix (ECM) degradation is a critical process in tumor cell invasion and requires matrix degrading protrusions called invadopodia. The…”
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Mitochondrial Dysfunction in Aging and Cancer by Moro, Loredana

“…Aging is a major risk factor for developing cancer, suggesting that these two events may represent two sides of the same coin. It is becoming clear that some…”
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Loss of BRCA2 promotes prostate cancer cell invasion through up‐regulation of matrix metalloproteinase‐9 by Moro, Loredana, Arbini, Arnaldo A., Yao, Jorge L., Di Sant’Agnese, Paul A., Marra, Ersilia, Greco, Margherita

“…BRCA2 is a multifunctional tumor suppressor protein which plays critical roles in DNA repair, transcription, and cell proliferation, and the loss of which has…”
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Up-regulation of Skp2 after Prostate Cancer Cell Adhesion to Basement Membranes Results in BRCA2 Degradation and Cell Proliferation by Moro, Loredana, Arbini, Arnaldo A., Marra, Ersilia, Greco, Margherita

“…Aberrant interaction of carcinoma cells with basement membranes (BM) is a fundamental pathophysiological process that initiates a series of events resulting in…”
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Selective Modulation of Type 1 Insulin-Like Growth Factor Receptor Signaling and Functions by β1Integrins by Goel, Hira Lal, Fornaro, Mara, Moro, Loredana, Teider, Natalia, Rhim, Johng S., King, Michael, Languino, Lucia R.

“…We show here that β1integrins selectively modulate insulin-like growth factor type I receptor (IGF-IR) signaling in response to IGF stimulation. The β1…”
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Mitochondrial DNA depletion reduces PARP-1 levels and promotes progression of the neoplastic phenotype in prostate carcinoma by Moro, Loredana, Arbini, Arnaldo A, Marra, Ersilia, Greco, Margherita

“…Mitochondrial dysfunction resulting from mitochondrial DNA (mtDNA) mutations and/or depletion has been correlated with cancer progression and drug resistance…”
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Mitochondria at the Crossroads of Physiology and Pathology by Moro, Loredana

“…Mitochondria play a crucial role in cell life and death by regulating bioenergetic and biosynthetic pathways. They are able to adapt rapidly to different…”
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