Search Results - "Morningstar, Jordan E."

Mitral Valve Prolapse and Its Motley Crew-Syndromic Prevalence, Pathophysiology, and Progression of a Common Heart Condition by Morningstar, Jordan E, Nieman, Annah, Wang, Christina, Beck, Tyler, Harvey, Andrew, Norris, Russell A

“…Mitral valve prolapse (MVP) is a commonly occurring heart condition defined by enlargement and superior displacement of the mitral valve leaflet(s) during…”
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Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis by Morningstar, Jordan E, Gensemer, Cortney, Moore, Reece, Fulmer, Diana, Beck, Tyler C, Wang, Christina, Moore, Kelsey, Guo, Lilong, Sieg, Franz, Nagata, Yasufumi, Bertrand, Philippe, Spampinato, Ricardo A, Glover, Janiece, Poelzing, Stephen, Gourdie, Robert G, Watts, Kelsey, Richardson, William J, Levine, Robert A, Borger, Michael A, Norris, Russell A

“…Background Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging…”
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Application of Pharmacokinetic Prediction Platforms in the Design of Optimized Anti-Cancer Drugs by Beck, Tyler C, Springs, Kendra, Morningstar, Jordan E, Mills, Catherine, Stoddard, Andrew, Guo, Lilong, Moore, Kelsey, Gensemer, Cortney, Biggs, Rachel, Petrucci, Taylor, Kwon, Jennie, Stayer, Kristina, Koren, Natalie, Dunne, Jaclyn, Fulmer, Diana, Vohra, Ayesha, Mai, Le, Dooley, Sarah, Weninger, Julianna, Peterson, Yuri, Woster, Patrick, Dix, Thomas A, Norris, Russell A

“…Cancer is the second most common cause of death in the United States, accounting for 602,350 deaths in 2020. Cancer-related death rates have declined by 27%…”
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DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse by Moore, Kelsey S, Moore, Reece, Fulmer, Diana B, Guo, Lilong, Gensemer, Cortney, Stairley, Rebecca, Glover, Janiece, Beck, Tyler C, Morningstar, Jordan E, Biggs, Rachel, Muhkerjee, Rupak, Awgulewitsch, Alexander, Norris, Russell A

“…Mitral valve prolapse (MVP) is a common cardiac valve disease that often progresses to serious secondary complications requiring surgery. MVP manifests as…”
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Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral-Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review by van Kampen, Antonia, Morningstar, Jordan E, Goudot, Guillaume, Ingels, Neil, Wenk, Jonathan F, Nagata, Yasufumi, Yaghoubian, Koushiar M, Norris, Russell A, Borger, Michael A, Melnitchouk, Serguei, Levine, Robert A, Jensen, Morten O

“…The geometrical details and biomechanical relationships of the mitral valve-left ventricular apparatus are very complex and have posed as an area of research…”
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Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes by O'Sullivan, John F, Morningstar, Jordan E, Yang, Qiong, Zheng, Baohui, Gao, Yan, Jeanfavre, Sarah, Scott, Justin, Fernandez, Celine, Zheng, Hui, O'Connor, Sean, Cohen, Paul, Vasan, Ramachandran S, Long, Michelle T, Wilson, James G, Melander, Olle, Wang, Thomas J, Fox, Caroline, Peterson, Randall T, Clish, Clary B, Corey, Kathleen E, Gerszten, Robert E

“…Unbiased, "nontargeted" metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful…”
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Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease by Warren, Curtis R., O’Sullivan, John F., Friesen, Max, Becker, Caroline E., Zhang, Xiaoling, Liu, Poching, Wakabayashi, Yoshiyuki, Morningstar, Jordan E., Shi, Xu, Choi, Jihoon, Xia, Fang, Peters, Derek T., Florido, Mary H.C., Tsankov, Alexander M., Duberow, Eilene, Comisar, Lauren, Shay, Jennifer, Jiang, Xin, Meissner, Alexander, Musunuru, Kiran, Kathiresan, Sekar, Daheron, Laurence, Zhu, Jun, Gerszten, Robert E., Deo, Rahul C., Vasan, Ramachandran S., O’Donnell, Christopher J., Cowan, Chad A.

“…Genome-wide association studies (GWAS) have highlighted a large number of genetic variants with potential disease association, but functional analysis remains…”
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The Emerging Epidemic of Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: True, True, and Related? by Morningstar, Jordan E., Syn, Wing-Kin, Litwin, Sheldon E.

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Native and Post-Repair Residual Mitral Valve Prolapse Increases Forces Exerted on the Papillary Muscles: A Possible Mechanism for Localized Fibrosis? by Park, Matthew H., van Kampen, Antonia, Melnitchouk, Serguei, Wilkerson, Robert J., Nagata, Yasufumi, Zhu, Yuanjia, Wang, Hanjay, Pandya, Pearly K., Morningstar, Jordan E., Borger, Michael A., Levine, Robert A., Woo, Y. Joseph

“…Recent studies have linked mitral valve prolapse to localized myocardial fibrosis, ventricular arrhythmia, and even sudden cardiac death independent of mitral…”
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Abnormal Mechanics Relate to Myocardial Fibrosis and Ventricular Arrhythmias in Patients With Mitral Valve Prolapse by Nagata, Yasufumi, Bertrand, Philippe B., Baliyan, Vinit, Kochav, Jonathan, Kagan, Ruth D., Ujka, Kristian, Alfraidi, Hassan, van Kampen, Antonia, Morningstar, Jordan E., Dal-Bianco, Jacob P., Melnitchouk, Serguei, Holmvang, Godtfred, Borger, Michael A., Moore, Reece, Hua, Lanqi, Sultana, Razia, Calle, Pablo Villar, Yum, Brian, Guerrero, J. Luis, Neilan, Tomas G., Picard, Michael H., Kim, Jiwon, Delling, Francesca N., Hung, Judy, Norris, Russell A., Weinsaft, Jonathan W., Levine, Robert A.

“…The relation between ventricular arrhythmia and fibrosis in mitral valve prolapse (MVP) is reported, but underlying valve-induced mechanisms remain unknown. We…”
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Left ventricular fibrosis and CMR tissue characterization of papillary muscles in mitral valve prolapse patients by Spampinato, Ricardo A., Marin-Cuartas, Mateo, van Kampen, Antonia, Fahr, Florian, Sieg, Franz, Strotdrees, Elfriede, Jahnke, Cosima, Klaeske, Kristin, Wiesner, Karoline, Morningstar, Jordan E., Nagata, Yasufumi, Izquierdo-Garcia, David, Dieterlen, Maja-Theresa, Norris, Russell A., Levine, Robert A., Paetsch, Ingo, Borger, Michael A.

“…Purpose Mitral valve prolapse (MVP) is associated with left ventricle (LV) fibrosis, including the papillary muscles (PM), which is in turn linked to malignant…”
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Cisplatin Analogs Confer Protection against Cyanide Poisoning by Nath, Anjali K, Shi, Xu, Harrison, Devin L, Morningstar, Jordan E, Mahon, Sari, Chan, Adriano, Sips, Patrick, Lee, Jangwoen, MacRae, Calum A, Boss, Gerry R, Brenner, Matthew, Gerszten, Robert E, Peterson, Randall T

“…Cisplatin holds an illustrious position in the history of chemistry most notably for its role in the virtual cure of testicular cancer. Here we describe a role…”
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Secreted frizzled related-protein 2 is prognostic for human pancreatic cancer patient survival and is associated with fibrosis by Siegel, Julie B, Nasarre, Patrick, Hsu, Lillian, Mukherjee, Rupak, Gormley, Meghan, Richardson, Bailey, Khan, Imran, Morningstar, Jordan E, Hilliard, Eleanor, O'Bryan, John P, Helke, Kristi L, Spruill, Laura, Dolloff, Nathan G, Klauber-DeMore, Nancy

“…Pancreatic adenocarcinoma (PDAC) is one of the deadliest cancers, with five-year survival rates of 9%. We hypothesized that secreted frizzled-related protein 2…”
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Cellular and Molecular Mechanisms of MEK1 Inhibitor-Induced Cardiotoxicity by Beck, Tyler C, Arhontoulis, Dimitrios C, Morningstar, Jordan E, Hyams, Nathaniel, Stoddard, Andrew, Springs, Kendra, Mukherjee, Rupak, Helke, Kris, Guo, Lilong, Moore, Kelsey, Gensemer, Cortney, Biggs, Rachel, Petrucci, Taylor, Kwon, Jennie, Stayer, Kristina, Koren, Natalie, Harvey, Andrew, Holman, Heather, Dunne, Jaclyn, Fulmer, Diana, Vohra, Ayesha, Mai, Le, Dooley, Sarah, Weninger, Julianna, Vaena, Silvia, Romeo, Martin, Muise-Helmericks, Robin C, Mei, Ying, Norris, Russell A

“…Trametinib is a MEK1 (mitogen-activated extracellular signal-related kinase kinase 1) inhibitor used in the treatment of BRAF (rapid accelerated fibrosarcoma…”
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Association of Acylcarnitines With Left Ventricular Remodeling in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement by Elmariah, Sammy, Farrell, Laurie A, Furman, Deborah, Lindman, Brian R, Shi, Xu, Morningstar, Jordan E, Rhee, Eugene P, Gerszten, Robert E

“…Clinical practice guidelines currently endorse a reliance on clinical symptoms of overt left ventricular (LV) failure to time aortic valve replacement for…”
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Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk by Ngo, Debby, Benson, Mark D, Long, Jonathan Z, Chen, Zsu-Zsu, Wang, Ruiqi, Nath, Anjali K, Keyes, Michelle J, Shen, Dongxiao, Sinha, Sumita, Kuhn, Eric, Morningstar, Jordan E, Shi, Xu, Peterson, Bennet D, Chan, Christopher, Katz, Daniel H, Tahir, Usman A, Farrell, Laurie A, Melander, Olle, Mosley, Jonathan D, Carr, Steven A, Vasan, Ramachandran S, Larson, Martin G, Smith, J Gustav, Wang, Thomas J, Yang, Qiong, Gerszten, Robert E

“…Recent advances in proteomic technologies have made high-throughput profiling of low-abundance proteins in large epidemiological cohorts increasingly feasible…”
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Abstract 15359: Multi-Omics Integration Reveals Mechanosensitive Regulatory Pathways in Cardiac Fibroblasts by Morningstar, Jordan E, Beck, Tyler, Gensemer, Cortney, Biggs, Rachel, Petrucci, Taylor, Guo, Lilong, Vohra, Ayesha, Mai, Le, Gonzalez, Melfry, Stoddard, Andrew, Dunne, Jaclyn, Norris, Russell A

“…IntroductionRegionalized myocardial fibrosis exists in the inferobasal myocardium of patients undergoing surgical repair for Mitral Valve Prolapse, and…”
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Abstract 9400: Mitral Valve Prolapse Induces Regionalized Left Ventricular Fibrosis by Morningstar, Jordan E, Gensemer, Cortney, Moore, Reece, Fulmer, Diana B, Beck, Tyler, Wang, Christina, Moore, Kelsey, Guo, Lilong, Vohra, Ayesha, Sieg, Franz, Nagata, Yasufumi, Bertrand, Philippe, Spampinato, Ricardo, Glover, Janiece, Poelzing, Stephen, Gourdie, Robert G, Richardson, William, Levine, Robert A, Borger, Michael, Norris, Russell A

“…IntroductionImaging studies patients with mitral valve prolapse (MVP) have previously shown cross sectional evidence of left ventricular (LV) fibrosis as well…”
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Abstract 13814: DMGV is a Novel Marker of Liver Fat and Predicts Future Development of Type 2 Diabetes by O’Sullivan, John F, Morningstar, Jordan E, Zheng, Baohui, Jeanfavre, Sarah, Scott, Justin, Yang, Qiong, Fernandez, Celine, Vasan, Rakmachandran S, Long, Michelle T, Melander, Olle, Wang, Thomas J, Fox, Caroline, Peterson, Randall T, Clish, Clary, Corey, Kathleen, Gerszten, Robert E

“…BackgroundUnbiased “non-targeted” metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, though there have been few…”
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Proteomic profiling reveals novel biomarkers and pathways in yype 2 diabetes risk by Ngo, Debby, Benson, Mark D, Long, Jonathan Z, Chen, Zsu-Zsu, Wang, Ruiqi, Nath, Anjali K, Keyes, Michelle J, Shen, Dongxiao, Sinha, Sumita, Kuhn, Eric, Morningstar, Jordan E, Shi, Xu, Peterson, Bennet D, Chan, Christopher, Katz, Daniel H, Tahir, Usman A, Farrell, Laurie A, Melander, Olle, Mosley, Jonathan D, Carr, Steven A, Vasan, Ramachandran S, Larson, Martin G, Smith, J Gustav, Wang, Thomas J, Yang, Qiong, Gerszten, Robert E

“…Recent advances in proteomic technologies have made high throughput profiling of low abundance proteins in large epidemiological cohorts increasingly feasible…”
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