Search Results - "Morliere, Patrice"

Increased gut permeability and bacterial translocation after chronic chlorpyrifos exposure in rats by Joly Condette, Claire, Khorsi-Cauet, Hafida, Morlière, Patrice, Zabijak, Luciane, Reygner, Julie, Bach, Véronique, Gay-Quéheillard, Jérôme

“…The epithelium's barrier function is crucial for maintaining homeostasis and preventing the passage of food antigens and luminal bacteria. This function is…”
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High extracellular inorganic phosphate concentration inhibits RANK-RANKL signaling in osteoclast-like cells by Mozar, Anaïs, Haren, Nathalie, Chasseraud, Maud, Louvet, Loïc, Mazière, Cécile, Wattel, Alice, Mentaverri, Romuald, Morlière, Patrice, Kamel, Saïd, Brazier, Michel, Mazière, Jean C., Massy, Ziad A.

“…In this work, we investigated the effect of inorganic phosphate (Pi) on the differentiation of monocyte/macrophage precursors into an “osteoclastic” phenotype,…”
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Oxidative stress is independent of inflammation in the neurodegenerative sanfilippo syndrome type B by Trudel, Stéphanie, Trécherel, Eric, Gomila, Cathy, Peltier, Maxime, Aubignat, Michaël, Gubler, Brigitte, Morlière, Patrice, Heard, Jean-Michel, Ausseil, Jérôme

“…Mucopolysaccharidosis (MPS) type IIIB is a genetic deficiency of α‐N‐acetylglucosaminidase, inducing accumulation of partially degraded heparan sulfate (HS)…”
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Interplay Between Membrane Lipid Peroxidation and Photoproduct Formation in the Ultraviolet A-Induced Phototoxicity of Vemurafenib in Skin Keratinocytes by Teixeira, Ana, Morlière, Patrice, Ferreira, João, Conte, Marie-Alix, Galmiche, Antoine, Mazière, Jean-Claude, Santus, René, Filipe, Paulo

“…According to some authors, the phototoxic response to ultraviolet A (UVA) of patients treated with vemurafenib (VB) may involve VB metabolites. However, the…”
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Evidence for a slow and oxygen-insensitive intra-molecular long range electron transfer from tyrosine residues to the semi-oxidized tryptophan 214 in human serum albumin: its inhibition by bound copper (II) by Patterson, Larry K., Mazière, Jean-Claude, Bartels, David M., Hug, Gordon L., Santus, René, Morlière, Patrice

“…A slow, long range electron transfer (SLRET) in human serum albumin (HSA) is observed from an intact tyrosine (Tyr) residue to the neutral tryptophan (Trp)…”
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Dynamics of interactions of photosensitizers with lipoproteins and membrane-models: correlation with cellular incorporation and subcellular distribution by Bonneau, Stéphanie, Morlière, Patrice, Brault, Daniel

“…The incorporation and subcellular localization of photosensitizers are critical determinants of their efficiency. Here, we correlate these properties with the…”
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Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry by Santos, Clementina M.M., Garcia, M. Beatriz Q., Silva, Artur M.S., Santus, René, Morlière, Patrice, Fernandes, Eduarda

“…The present study reports the electrochemical behavior of several phenolic and catecholic-substituted 2,3-diarylxanthones on a glassy carbon electrode,…”
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Distribution and quantitation of skin iron in primary haemochromatosis: correlation with total body iron stores in patients undergoing phlebotomy by Pinheiro, Teresa, Silva, Raquel, Fleming, Rita, Gonçalves, Afonso, Barreiros, Maria A, Silva, João N, Morlière, Patrice, Santus, René, Filipe, Paulo

“…Measurement of the concentration of iron in the skin, if correlated with total body iron stores, may enable better informed decisions on when to initiate,…”
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Targeting TNFα in severe psoriasis-mass spectrometry reveals a time-dependent specific inhibition of Factor H in responding patients by Morlière, Patrice, Antunes, Joana F, Nourry, Virginie, Amado, Francisco M, Domingues, Pedro M, Guerreiro, Ana C, Ferreira, João A, Maia-Silva, João N, Mazière, Jean-Claude, Santus, René C, Filipe, Paulo L

“…Drugs targeting TNFα (eg, Etanercept®) provide effective control of severe psoriasis. In absence of validated biological parameters of inflammation in…”
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Uremic Toxin Indoxyl Sulfate Inhibits Human Vascular Smooth Muscle Cell Proliferation by Mozar, Anaïs, Louvet, Loïc, Morlière, Patrice, Godin, Corinne, Boudot, Cédric, Kamel, Saïd, Drüeke, Tilman B, Massy, Ziad A

“…Uremic syndrome is attributed to the progressive retention of a large number of compounds, such as indoxyl sulfate, which under physiological conditions are…”
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Chain-dependent photocytotoxicity of tricationic porphyrin conjugates and related mechanisms of cell death in proliferating human skin keratinocytes by Silva, João Nuno, Galmiche, Antoine, Tomé, João P.C., Boullier, Agnès, Neves, Maria G.P.M.S., Silva, Eduarda M.P., Capiod, Jean-Claude, Cavaleiro, José A.S., Santus, René, Mazière, Jean-Claude, Filipe, Paulo, Morlière, Patrice

“…Photodynamic therapy (PDT) is a poor treatment option for nodular basal cell carcinomas and squamous cell carcinomas. As a result, the search for new…”
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Structure-activity relationships in hydroxy-2,3-diarylxanthone antioxidants. Fast kinetics spectroscopy as a tool to evaluate the potential for antioxidant activity in biological systems by Santos, Clementina M M, Silva, Artur M S, Filipe, Paulo, Santus, René, Patterson, Larry K, Mazière, Jean-Claude, Cavaleiro, José A S, Morlière, Patrice

“…A structure-activity relationship has been established for eight hydroxy-2,3-diarylxanthones (XH) bearing hydroxy groups on the two aryl rings. One-electron…”
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The dependence of α-tocopheroxyl radical reduction by hydroxy-2,3-diarylxanthones on structure and micro-environment by Morlière, Patrice, Patterson, Larry K, Santos, Clementina M M, Silva, Artur M S, Mazière, Jean-Claude, Filipe, Paulo, Gomes, Ana, Fernandes, Eduarda, Garcia, M Beatriz Q, Santus, René

“…The flavonoid quercetin is known to reduce the α-tocopheroxyl radical (˙TocO) and reconstitute α-tocopherol (TocOH). Structurally related polyphenolic…”
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One-Electron Reduction of Superoxide Radical-Anions by 3-Alkylpolyhydroxyflavones in Micelles. Effect of Antioxidant Alkyl Chain Length on Micellar Structure and Reactivity by Silva, Artur M. S, Filipe, Paulo, Seixas, Raquel S. G. R, Pinto, Diana C. G. A, Patterson, Larry K, Hug, Gordon L, Cavaleiro, José A. S, Mazière, Jean-Claude, Santus, René, Morlière, Patrice

“…In micellar solutions, one-electron reduction of •O2 − radical-anions by 3-alkylpolyhydroxyflavones (FnH) with alkyl chains of n = 1, 4, 6, 10 carbons produces…”
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The alkyl chain length of 3-alkyl-3′,4′,5,7-tetrahydroxyflavones modulates effective inhibition of oxidative damage in biological systems: Illustration with LDL, red blood cells and human skin keratinocytes by Filipe, Paulo, Silva, Artur M.S., Seixas, Raquel S.G.R., Pinto, Diana C.G.A., Santos, Alvaro, Patterson, Larry K., Silva, João N., Cavaleiro, José A.S., Freitas, João P., Mazière, Jean-Claude, Santus, René, Morlière, Patrice

“…It is shown that the relationship between the alkyl chain length of 3-alkyl-3′,4′,5,7 tetrahydroxyflavones (FnH) bearing alkyl chains of n = 1, 4, 6, 10…”
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Photophysical properties of a photocytotoxic fluorinated chlorin conjugated to four beta-cyclodextrins by Silva, João Nuno, Silva, Ana M G, Tomé, João P, Ribeiro, Anderson O, Domingues, M Rosário M, Cavaleiro, José A S, Silva, Artur M S, Neves, M Graça P M S, Tomé, Augusto C, Serra, Osvaldo A, Bosca, Francisco, Filipe, Paulo, Santus, René, Morlière, Patrice

“…A meso-tetrakis(pentafluorophenyl)-chlorin with the reduced pyrrole ring linked to an isoxazolidine ring (FC) has been conjugated to four beta-cyclodextrins…”
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Plasma Lipoproteins as Mediators of the Oxidative Stress Induced by UV Light in Human Skin : A Review of Biochemical and Biophysical Studies on Mechanisms of Apolipoprotein Alteration, Lipid Peroxidation, and Associated Skin Cell Responses by Morlière, Patrice, Mazière, Jean-Claude, Filipe, Paulo, Santus, R., Freitas, João Pedro, Patterson, Larry K., Silva, João N.

“…There are numerous studies concerning the effect of UVB light on skin cells but fewer on other skin components such as the interstitial fluid. This review…”
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Tricationic Porphyrin Conjugates: Evidence for Chain-Structure-Dependent Relaxation of Excited Singlet and Triplet States by Silva, João Nuno, Bosca, Francisco, Tomé, João P. C, Silva, Eduarda M. P, Neves, Maria G. P. M. S, Cavaleiro, José A. S, Patterson, Larry K, Filipe, Paulo, Mazière, Jean-Claude, Santus, René

“…Conjugates of 5-(4-carboxyphenyl)-10,15,20-tris(4-methylpyridinium-4-yl)porphyrin (P−H) are promising photoactive agents for medical applications. As their…”
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Inhibition of insulin signaling by oxidized low density lipoprotein: Protective effect of the antioxidant Vitamin E by Mazière, Cécile, Morlière, Patrice, Santus, René, Marcheux, Virginie, Louandre, Christophe, Conte, Marie-Alix, Mazière, Jean-Claude

“…Oxidative stress is involved in several pathological conditions, including diabetes. Reactive oxygen species (ROS) have been demonstrated to act as second…”
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Equilibrium and Kinetic Studies of the Interactions of a Porphyrin with Low-Density Lipoproteins by Bonneau, Stéphanie, Vever-Bizet, Christine, Morlière, Patrice, Mazière, Jean-Claude, Brault, Daniel

“…Low-density lipoproteins (LDL) play a key role in the delivery of photosensitizers to tumor cells in photodynamic therapy. The interaction of deuteroporphyrin,…”
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