Search Results - "Morliere, P."

Photosensitisation by voriconazole-N-oxide results from a sequence of solvent and pH-dependent photochemical and thermal reactions by Morlière, P., Silva, A.M.S., Seixas, R.S.G.R., Boscá, F., Mazière, J.-C., Ferreira, J., Santus, R., Filipe, P.

“…The phototoxicity of voriconazole (VN) prescribed in the treatment of severe fungal infections is frequently reported. Its major metabolite, a N-oxide…”
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A molecular insight into the phototoxic reactions observed with vemurafenib, a first-line drug against metastatic melanoma by Morlière, P, Boscá, F, Silva, A M S, Teixeira, A, Galmiche, A, Mazière, J-C, Nourry, V, Ferreira, J, Santus, R, Filipe, P

“…The electronic properties of vemurafenib (VB) provide a rational basis for understanding its strong UVA-induced phototoxicity. Thus, solvation of hydrophobic…”
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Endoplasmic reticulum and Golgi apparatus are the preferential sites of Foscan localisation in cultured tumour cells by TEITEN, M-H, BEZDETNAYA, L, MORLIERE, P, SANTUS, R, GUILLEMIN, F

“…Intracellular photosensitiser localisation significantly influences the mechanism of response to photodynamic therapy (PDT), since the primary sites of damage…”
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Chemistry of free radicals produced by oxidation of endogenous α-aminoketones. A study of 5-aminolevulinic acid and α-aminoacetone by fast kinetics spectroscopy by Morlière, P., Hug, G.L., Patterson, L.K., Mazière, J.-C., Ausseil, J., Dupas, J.-L., Ducroix, J.-P., Santus, R., Filipe, P.

“…Excess 5-aminolevulinic acid (ALA) and α-aminoacetone (AA) are implicated in ketosis, porphyrinpathies and diabetes. Pathologic manifestations involve O2−,…”
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On the repair of oxidative damage to apoferritin: a model study with the flavonoids quercetin and rutin in aerated and deaerated solutions by Morlière, P, Mazière, J-C, Patterson, L K, Conte, M-A, Dupas, J-L, Ducroix, J-P, Filipe, P, Santus, R

“…Ferritin (Ft) impairment through (•)O2(-), H2O2, and (•)OH production occurs in the cases of ketoses, diabetes mellitus, acute intermittent porphyria and…”
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Action spectrum for UV-induced lipid peroxidation in cultured human skin fibroblasts by Morliere, Patrice, Moysan, Annie, Tirache, Isabelle

“…Lipid peroxidation was measured by release of thiobarbituric acid-reactive substances (TBARS) into the supernatant of cultured human skin fibroblasts. This…”
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Lysosomes Are Sites of Fluoroquinolone Photosensitization in Human Skin Fibroblasts: A Microspectrofluorometric Approach by Ouedraogo, G., Morliere, P., Bazin, M., Santus, R., Kratzer, B., Miranda, M. A., Castell, J. V.

“… The fluoroquinolone antibiotics are widely used despite their strong phototoxicity under solar UV irradiation. Although they are known as good photodynamic…”
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Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones by Ouédraogo, G, Morlière, P, Santus, R, Miranda, M.A, Castell, J.V

“…The phototoxic fluoroquinolones ofloxacin, lomefloxacin, norfloxacin, ciprofloxacin and BAYy 3118 have ionizable groups with p K a values close to neutrality…”
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Low UVA doses activate the transcription factor NFAT in human fibroblasts by a calcium–calcineurin pathway by Mazière, Cécile, Morlière, Patrice, Louandre, Christophe, Conte, Marie-Alix, Gomilla, Cathy, Santus, René, Antonicelli, Franck, Hornebeck, William, Mazière, Jean-Claude

“…UVA radiation induces an inflammatory response as observed in erythema, and the cytokine genes involved in this response are under the control of the…”
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Flavonoids and urate antioxidant interplay in plasma oxidative stress by Filipe, P, Lança, V, Silva, J N, Morlière, P, Santus, R, Fernandes, A

“…Flavonoids are naturally occurring plant compounds with antioxidant properties. Their consumption has been associated with the protective effects of certain…”
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Riboflavin Photodegradation and Photosensitizing Effects are Highly Dependent on Oxygen and Ascorbate Concentrations by Rochette, Arnauld de La, Silva, Eduardo, Birlouez-Aragon, Inès, Mancini, Marcelo, Edwards, Ana-Maria, Morlière, Patrice

“…Riboflavin (RF) is a normal component of the eye lens which triggers a strong photosensitizing activity when exposed to light. Upon irradiation with short…”
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Sensitization of skin fibroblasts to UVA by excess iron by Morlière, P, Salmon, S, Aubailly, M, Risler, A, Santus, R

“…Human skin chronically exposed to UV light is known to accumulate iron and to have an increased ferritin content as compared to unexposed areas. Iron…”
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Alteration of the Endocytotic Pathway by Photosensitization with Fluoroquinolones by Ouédraogo, G., Morlière, P., Mazière, C., Mazière, J. C., Santus, R.

“…The endocytotic pathway is profoundly altered by the UVA-induced photosensitization of HS 68 fibroblasts by the fluoroquinolone (FQ) antibiotics lomefloxacin,…”
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Tolyporphin : A natural product from cyanobacteria with potent photosensitizing activity against tumor cells in vitro and in vivo by MORLIERE, P, MAZIERE, J.-C, SANTUS, R, SMITH, C. D, PRINSEP, M. R, STOBBE, C. C, FENNING, M. C, GOLBERG, J. L, CHAPMAN, J. D

“…Tolyporphin (TP), a porphyrin extracted from cyanobacteria, was found to be a very potent photosensitizer of EMT-6 tumor cells grown both in vitro as…”
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UVA-induced immune suppression in human skin: protective effect of vitamin E in human epidermal cells in vitro by CLEMENT-LACROIX, P., MICHEL, L., MOYSAN, A., MORLIERE, P., DUBERTRET, L.

“…Summary UVA (320–400nm) radiation damage to membranes, proteins, DNA and other cellular targets is predominantly related to oxidative processes. In the present…”
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Redox reactions of the urate radical/urate couple with the superoxide radical anion, the tryptophan neutral radical and selected flavonoids in neutral aqueous solutions by Santus, R, Patterson, L K, Filipe, P, Morlière, P, Hug, G L, Fernandes, A, Mazière, J C

“…The kinetics of several processes involving the potential antioxidant role of urate in physiological systems have been investigated by pulse radiolysis. While…”
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Role of Nuclear Factor-Kappa B in Colon Cancer Cell Apoptosis Mediated by Aminopyropheophorbide Photosensitization by Matroule, J. Y., Hellin, Anne-Cécile, Morliere, P., Fabiano, A. S., Santus, R., Merville, Marie-Paule, Piette, Jacques

“…Aminopyropheophorbide (APP) is a second generation of photosensitizer for photodynamic therapy (PDT). We demonstrated that APP strongly absorbed red light and,…”
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UV photolysis of catalase revisited: a spectral study of photolytic intermediates by Aubailly, Michel, Haigle, Josiane, Giordani, Anne, Morlière, Patrice, Santus, René

“…The 365-nm irradiation of 4.6 μM (≃1.1 mg/ml) catalase solutions in pH 7.4 phosphate buffer induces spectral modifications. Difference spectra show maxima at…”
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Inactivation of Iron Responsive Element–binding Capacity and Aconitase Function of Iron Regulatory Protein-1 of Skin Cells by Ultraviolet A by Giordani, Anne, Martin, Marie-Elise, Beaumont, Carole, Santus, René, Morlière, Patrice

“…The ultraviolet-A (UVA) component of sunlight produces in cutaneous cells a highly toxic oxidative stress mediated by redox cycling reactions of Fe ions. A…”
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Interactions of superoxide anion with enzyme radicals: kinetics of reaction with lysozyme tryptophan radicals and corresponding effects on tyrosine electron transfer by Santus, R, Patterson, L K, Hug, G L, Bazin, M, Mazière, J C, Morlière, P

“…The kinetics of O2*- reaction with semi-oxidized tryptophan radicals in lysozyme, Trp*(Lyz) have been investigated at various pHs and conformational states by…”
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