Search Results - "Morley, G E"

Visualization and functional characterization of the developing murine cardiac conduction system by Rentschler, S, Vaidya, D M, Tamaddon, H, Degenhardt, K, Sassoon, D, Morley, G E, Jalife, J, Fishman, G I

“…The cardiac conduction system is a complex network of cells that together orchestrate the rhythmic and coordinated depolarization of the heart. The molecular…”
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Reentry and Fibrillation in the Mouse Heart: A Challenge to the Critical Mass Hypothesis by Vaidya, Dhananjay, Morley, Gregory E, Samie, Faramarz H, Jalife, José

“…The idea that fibrillation is only possible in hearts exceeding a critical size was introduced by W. Garrey >80 years ago and has since been generally…”
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Effect of basolateral or apical hyposmolarity on apical maxi K channels of everted rat collecting tubule by Stoner, L C, Morley, G E

“…We are able to evert and perfuse rat cortical collecting tubules (CCT) at 37 degrees C. Patch-clamp techniques were used to study high-conductance potassium…”
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Conduction Slowing and Sudden Arrhythmic Death in Mice With Cardiac-Restricted Inactivation of Connexin43 by Gutstein, David E, Morley, Gregory E, Tamaddon, Houman, Vaidya, Dhananjay, Schneider, Michael D, Chen, Ju, Chien, Kenneth R, Stuhlmann, Heidi, Fishman, Glenn I

“…ABSTRACT—Cardiac arrhythmia is a common and often lethal manifestation of many forms of heart disease. Gap junction remodeling has been postulated to…”
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Dynamics of the inward rectifier K+ current during the action potential of guinea pig ventricular myocytes by Ibarra, J., Morley, G.E., Delmar, M.

“…The potassium selective, inward rectifier current (IK1) is known to be responsible for maintaining the resting membrane potential of quiescent ventricular…”
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Molecular and functional maturation of the murine cardiac conduction system by Rentschler, S, Morley, G E, Fishman, G I

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Early onset heart failure in transgenic mice with dilated cardiomyopathy by HALL, D. G, MORLEY, G. E, VAIDYA, D, ARD, M, KIMBALL, T. R, WITT, S. A, COLBERT, M. C

“…In children, dilated cardiomyopathy is due to a variety of etiologies and usually carries a grave prognosis. The purpose of the present study was to carefully…”
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Heterogeneous expression of gap junction channels in the heart leads to conduction defects and ventricular dysfunction by GUTSTEIN, David E, MORLEY, Gregory E, VAIDYA, Dhananjay, LIU, Fangyu, CHEN, Franklin L, STUHLMANN, Heidi, FISHMAN, Glenn I

“…- Heterogeneous remodeling of gap junctions is observed in many forms of heart disease. The consequent loss of synchronous ventricular activation has been…”
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Characterization of Conduction in the Ventricles of Normal and Heterozygous Cx43 Knockout Mice Using Optical Mapping by MORLEY, GREGORY E., VAIDYA, DHANANJAY, SAMIE, FARAMARZ H., LO, CECILIA, DELMAR, MARIO, JALIFE, JOSÉ

“…Conduction in Normal and C×43+/− Mice. Introduction: Gap junction channels are important determinants of conduction in the heart and may play a central role in…”
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High-Resolution Optical Mapping of the Right Bundle Branch in Connexin40 Knockout Mice Reveals Slow Conduction in the Specialized Conduction System by Tamaddon, Houman S, Vaidya, Dhananjay, Simon, Alexander M, Paul, David L, Jalife, José, Morley, Gregory E

“…Connexin40 (Cx40) is a major gap junction protein that is expressed in the His-Purkinje system and thought to be a critical determinant of cell-to-cell…”
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Null Mutation of Connexin43 Causes Slow Propagation of Ventricular Activation in the Late Stages of Mouse Embryonic Development by Vaidya, Dhananjay, Tamaddon, Houman S, Lo, Cecilia W, Taffet, Steven M, Delmar, Mario, Morley, Gregory E, Jalife, José

“…Connexin43 (Cx43) is the principal connexin isoform in the mouse ventricle, where it is thought to provide electrical coupling between cells. Knocking out this…”
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Intramolecular interactions mediate pH regulation of connexin43 channels by Morley, G.E., Taffet, S.M., Delmar, M.

“…We have previously proposed that acidification-induced regulation of the cardiac gap junction protein connexin43 (Cx43) may be modeled as a particle-receptor…”
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Connexins and Impulse Propagation in the Mouse Heart by JALIFE, JOSÉ, MORLEY, GREGORY E., VAIDYA, DHANANJAY

“…Connexins and Propagation. Gap junction channels are essential for normal cardiac impulse propagation. Three gap Junction proteins, known as connexins, are…”
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PH regulation of connexin43: molecular analysis of the gating particle by Ek-Vitorín, J.F., Calero, G., Morley, G.E., Coombs, W., Taffet, S.M., Delmar, M.

“…Gap junction channels allow for the passage of ions and small molecules between neighboring cells. These channels are formed by multimers of an integral…”
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Understanding conduction of electrical impulses in the mouse heart using high-resolution video imaging technology by Morley, Gregory E., Vaidya, Dhananjay

“…The conduction of electrical impulses in the heart depends on the ability to efficiently transfer excitatory current between individual myocytes. Several…”
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A Fungal Metabolite That Eliminates Motion Artifacts by JALIFE, JOSÉ, MORLEY, GREGORY E., TALLINI, N. YVONNE, VAIDYA, DHANANJAY

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Conditional gene targeting of connexin43: exploring the consequences of gap junction remodeling in the heart by Gutstein, D E, Morley, G E, Fishman, G I

“…Abnormalities in cardiac gap junction expression have been postulated to contribute to arrhythmias and ventricular dysfunction. We investigated the role of…”
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Cardiac Gap Junction Remodeling by Stretch: Is It a Good Thing? by Morley, Gregory E, Jalife, José

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Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing by Quinn, T.A., Granite, S., Allessie, M.A., Antzelevitch, C., Bollensdorff, C., Bub, G., Burton, R.A.B., Cerbai, E., Chen, P.S., Delmar, M., DiFrancesco, D., Earm, Y.E., Efimov, I.R., Egger, M., Entcheva, E., Fink, M., Fischmeister, R., Franz, M.R., Garny, A., Giles, W.R., Hannes, T., Harding, S.E., Hunter, P.J., Iribe, G., Jalife, J., Johnson, C.R., Kass, R.S., Kodama, I., Koren, G., Lord, P., Markhasin, V.S., Matsuoka, S., McCulloch, A.D., Mirams, G.R., Morley, G.E., Nattel, S., Noble, D., Olesen, S.P., Panfilov, A.V., Trayanova, N.A., Ravens, U., Richard, S., Rosenbaum, D.S., Rudy, Y., Sachs, F., Sachse, F.B., Saint, D.A., Schotten, U., Solovyova, O., Taggart, P., Tung, L., Varró, A., Volders, P.G., Wang, K., Weiss, J.N., Wettwer, E., White, E., Wilders, R., Winslow, R.L., Kohl, P.

“…Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As…”
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Service Doctors' Pay Award by Morley, G. E.

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