Search Results - "Morla, Shravan"

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation by Morla, Shravan

“…Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming…”
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A Unique Nonsaccharide Mimetic of Heparin Hexasaccharide Inhibits Colon Cancer Stem Cells via p38 MAP Kinase Activation by Boothello, Rio S, Patel, Nirmita J, Sharon, Chetna, Abdelfadiel, Elsamani I, Morla, Shravan, Brophy, Donald F, Lippman, H Robert, Desai, Umesh R, Patel, Bhaumik B

“…Targeting of cancer stem cells (CSC) is expected to be a paradigm-shifting approach for the treatment of cancers. Cell surface proteoglycans bearing sulfated…”
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Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8 by Morla, Shravan, Desai, Umesh R

“…Elevated matrix metalloproteinase-8 (MMP-8) activity contributes to the etiology of many diseases, including atherosclerosis, pulmonary fibrosis, and sepsis…”
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Harnessing Twitter to empower scientific engagement and communication: The ISTH 2020 virtual congress experience by Othman, Maha, Cormier, Matthew, Barnes, Geoffrey D., Comer, Shane P., Connors, Jean M., Denorme, Frederik, Khorana, Alok A., Las Casas, Pedro Henrique, Morla, Shravan, Muia, Joshua, Ní Áinle, Fionnuala, Taylor, Kirk A., van der Wal, Dianne E., Weyand, Angela C., Lavin, Michelle

“…As a result of the coronavirus disease 2019 pandemic, the International Society on Thrombosis and Haemostasis (ISTH), like many societies around the world,…”
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Novel blood coagulation molecules: Skeletal muscle myosin and cardiac myosin by Deguchi, Hiroshi, Morla, Shravan, Griffin, John H.

“…Essentials Striated muscle myosins can promote prothrombin activation by FXa or FVa inactivation by APC. Cardiac myosin and skeletal muscle myosin are…”
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Procoagulant Activity of Skeletal Muscle Myosin Is Not Caused By Contaminating Phosphatidylserine-Vesicles by Morla, Shravan, Deguchi, Hiroshi, Brekken, Rolf, Griffin, John H.

“…Skeletal muscle myosin (SkM) can bind factor (F)Xa and FVa, thereby providing a surface that promotes thrombin generation by the prothrombinase complex…”
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Skeletal muscle myosin and cardiac myosin attenuate heparin's antithrombin‐dependent anticoagulant activity by Morla, Shravan, Deguchi, Hiroshi, Griffin, John H.

“…Background Heparin enhances the ability of the plasma protease inhibitor, antithrombin, to neutralize coagulation factor Xa and thrombin. Skeletal muscle…”
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Abstract 2334: Non-Saccharide Glycosaminoglycan Mimetics Selectively Target Certain Receptor Tyrosine Kinases to Induce Anti-Cancer Stem Cell Activity by O’Hara, Connor, Morla, Shravan, Ongolu, Ravi Kumar, Sankaranarayanan, Nehru Viji, Patel, Nirmita, Boothello, Rio, Patel, Bhaumik, Desai, Umesh

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Skeletal Muscle Myosin Is Procoagulant By Binding Factor XI Via Its A3 Domain and Enhancing Factor XI Activation By Thrombin by Deguchi, Hiroshi, Morla, Shravan, Zilberman-Rudenko, Jevgenia, Gruber, Andras, McCarty, Owen J T, Srivastava, Priyanka, Gailani, David, Griffin, John H.

“…Blood coagulation mechanisms play key roles in health and disease. Pilot studies using selected human plasmas showed the potential associations of plasma…”
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Identification of 2‑Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay by Parker, Mackenzie J., Lee, Hyelee, Yao, Shihua, Irwin, Sean, Hwang, Sunil, Belanger, Kylie, de Mare, Sofia Woo, Surgenor, Richard, Yan, Lu, Gee, Patricia, Morla, Shravan, Puyang, Xiaoling, Hsiao, Peng, Zeng, Hao, Zhu, Ping, Korpal, Manav, Dransfield, Paul, Bolduc, David M., Larsen, Nicholas A.

“…Werner syndrome protein (WRN) is a multifunctional enzyme with helicase, ATPase, and exonuclease activities that are necessary for numerous DNA-related…”
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Skeletal muscle myosin promotes coagulation by binding factor XI via its A3 domain and enhancing thrombin-induced factor XI activation by Morla, Shravan, Deguchi, Hiroshi, Zilberman-Rudenko, Jevgenia, Gruber, András, McCarty, Owen J.T., Srivastava, Priyanka, Gailani, David, Griffin, John H.

“…Skeletal muscle myosin (SkM) has been shown to possess procoagulant activity; however, the mechanisms of this coagulation-enhancing activity involving plasma…”
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Selective Inhibition of a Panel of Cancer Stem Cell Lines by Novel Glycosaminoglycan Mimetics by O'Hara, Connor Patrick, Morla, Shravan, Afosah, Daniel, Sharon, Chetna, Boothello, Rio, Patel, Bhaumik, Desai, Umesh

“…Purpose To characterize the anti‐cancer stem cell (CSC) properties of non‐saccharide glycosaminoglycan mimetics (NSGMs) and their lipid‐modified analogs in a…”
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Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids by Morla, Shravan, Deguchi, Hiroshi, Fernández, José A., Ruf, Wolfram, Brekken, Rolf A., Griffin, John H.

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Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity by Morla, Shravan, Ravikumar, Ongolu, O’Hara, Connor, Boothello, Rio, Vera, Alberto, Abdelfadiel, Elsamani I., Fayyad, Rawan, Afosah, Daniel K., Sharon, Chetna, Fernandez, Leopoldo, Shah, Syed Ammer, Patel, Bhaumik B., Desai, Umesh R.

“…Sulfated glycosaminoglycans (GAGs), or synthetic mimetics thereof, are not favorably viewed as orally bioavailable drugs owing to their high number of anionic…”
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Abstract 6353: Cholesterol modification enhances potency and pharmacokinetic properties of a selective cancer stem cell targeting agent by O'Hara, Connor P., Boothello, Rio S., Morla, Shravan, Vera, Alberto, Afosah, Daniel K., Sankaranarayanan, Nehru V., Nagarajan, Balaji, Sharon, Chetna, Patel, Bhaumik B., Desai, Umesh R.

“…Abstract Increasing evidence supports the concept that tumor-initiating cancer stem cells (CSCs) are responsible for the relapse and reconstitution of formerly…”
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On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients by Morla, Shravan, Sankaranarayanan, Nehru Viji, Afosah, Daniel K, Kumar, Megh, Kummarapurugu, Apparao B, Voynow, Judith A, Desai, Umesh R

“…Cystic fibrosis (CF) is a disease of dysregulated salt and fluid homeostasis that results in the massive accumulation of neutrophil elastase, resulting in lung…”
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A small, synthetic glycosaminoglycan mimetic as an inhibitor of human heparanase by Sistla, Jyothi C., Afosah, Daniel K, Morla, Shravan, Patel, Nirmita J., Patel, Bhaumik B., Desai, Umesh R.

“…Human heparanase (HPSE) is an endo‐b‐D‐glucuronidase that cleaves glycosaminoglycan (GAG) chains of heparan sulfate proteoglycans (HSPGs) present on cell…”
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Lipophilic Modification of an Anti‐Cancer Stem Cell Agent Improves Pharmacokinetic and Anti‐Cancer Properties by Morla, Shravan, Afosah, Daniel K., O'Hara, Connor, Boothello, Rio, Patel, Bhaumik B., Sakagami, Masahiro, Desai, Umesh R.

“…Current anti‐cancer agents target bulk tumor cells but do not eradicate the rare, quiescent, cancer stem cells (CSCs). CSCs are being increasingly recognized…”
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Polymeric fluorescent heparin as one-step FRET substrate of human heparanase by Sistla, Jyothi C., Morla, Shravan, Alabbas, Al-Humaidi B., Kalathur, Ravi C., Sharon, Chetna, Patel, Bhaumik B., Desai, Umesh R.

“…•Development of polymeric heparin as a FRET substrate of heparanase.•The FRET substrate enables rapid, one-step screening of heparanase inhibitors.•The FRET…”
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A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding by Al‐Horani, Rami A., Abdelfadiel, Elsamani I., Afosah, Daniel K., Morla, Shravan, Sistla, Jyothi C., Mohammed, Bassem, Martin, Erika J., Sakagami, Masahiro, Brophy, Donald F., Desai, Umesh R.

“…Background Human factor XIa (FXIa) is an actively pursued target for development of safer anticoagulants. Our long‐standing hypothesis has been that…”
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