Search Results - "Moriscot, Anselmo"

Exercise training prevents oxidative stress and ubiquitin-proteasome system overactivity and reverse skeletal muscle atrophy in heart failure by Cunha, Telma F, Bacurau, Aline V N, Moreira, Jose B N, Paixão, Nathalie A, Campos, Juliane C, Ferreira, Julio C B, Leal, Marcelo L, Negrão, Carlos E, Moriscot, Anselmo S, Wisløff, Ulrik, Brum, Patricia C

“…Heart failure (HF) is known to lead to skeletal muscle atrophy and dysfunction. However, intracellular mechanisms underlying HF-induced myopathy are not fully…”
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Small-molecule mediated MuRF1 inhibition protects from doxorubicin-induced cardiac atrophy and contractile dysfunction by Alves, Paula K.N., Cruz, André, Adams, Volker, Moriscot, Anselmo S., Labeit, Siegfried

“…Cancer chemotherapy induces cell stress in rapidly dividing cancer cells to trigger their growth arrest and apoptosis. However, adverse effects related to…”
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Leucine supplementation improves skeletal muscle regeneration after cryolesion in rats by Pereira, Marcelo G, Baptista, Igor L, Carlassara, Eduardo O C, Moriscot, Anselmo S, Aoki, Marcelo S, Miyabara, Elen H

“…This study was undertaken in order to provide further insight into the role of leucine supplementation in the skeletal muscle regeneration process, focusing on…”
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Small-Molecule Inhibition of MuRF1 Prevents Early Disuse-Induced Diaphragmatic Dysfunction and Atrophy by Ribeiro, Fernando, Alves, Paula K N, Bechara, Luiz R G, Ferreira, Julio C B, Labeit, Siegfried, Moriscot, Anselmo S

“…In clinical conditions such as diaphragm paralysis or mechanical ventilation, disuse-induced diaphragmatic dysfunction (DIDD) is a condition that poses a…”
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MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance by Moriscot, Anselmo S., Baptista, Igor L., Bogomolovas, Julius, Witt, Christian, Hirner, Stephanie, Granzier, Henk, Labeit, Siegfried

“…MuRF1 is a member of the RBCC (RING, B-box, coiled-coil) superfamily that has been proposed to act as an atrogin during muscle wasting. Here, we show that…”
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Leucine and HMB differentially modulate proteasome system in skeletal muscle under different sarcopenic conditions by Baptista, Igor L, Silva, Willian J, Artioli, Guilherme G, Guilherme, Joao Paulo L F, Leal, Marcelo L, Aoki, Marcelo S, Miyabara, Elen H, Moriscot, Anselmo S

“…In the present study we have compared the effects of leucine supplementation and its metabolite β-hydroxy-β-methyl butyrate (HMB) on the ubiquitin-proteasome…”
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Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1 by Labeit, Siegfried, Hirner, Stephanie, Bogomolovas, Julijus, Cruz, André, Myrzabekova, Moldir, Moriscot, Anselmo, Bowen, Thomas Scott, Adams, Volker

“…The muscle-specific ubiquitin ligase MuRF1 regulates muscle catabolism during chronic wasting states, although its roles in general metabolism are…”
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TRB3 regulates skeletal muscle mass in food deprivation–induced atrophy by Choi, Ran Hee, McConahay, Abigail, Silvestre, João G., Moriscot, Anselmo S., Carson, James A., Koh, Ho‐Jin

“…ABSTRACTTribbles 3 (TRB3) is a pseudokinase that has been found in multiple tissues in response to various stress stimuli, such as nutrient deprivation and…”
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Loss of Parkin Results in Altered Muscle Stem Cell Differentiation during Regeneration by Esteca, Marcos V, Severino, Matheus B, Silvestre, João G, Palmeira Dos Santos, Gustavo, Tamborlin, Letícia, Luchessi, Augusto D, Moriscot, Anselmo S, Gustafsson, Åsa B, Baptista, Igor L

“…The high capacity of the skeletal muscle to regenerate is due to the presence of muscle stem cells (MuSCs, or satellite cells). The E3 ubiquitin ligase Parkin…”
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Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration by Moriscot, Anselmo, Miyabara, Elen H., Langeani, Bruno, Belli, Antonio, Egginton, Stuart, Bowen, T. Scott

“…One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing…”
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Leucine supplementation accelerates connective tissue repair of injured tibialis anterior muscle by Pereira, Marcelo G, Silva, Meiricris T, Carlassara, Eduardo O C, Gonçalves, Dawit A, Abrahamsohn, Paulo A, Kettelhut, Isis C, Moriscot, Anselmo S, Aoki, Marcelo S, Miyabara, Elen H

“…This study investigated the effect of leucine supplementation on the skeletal muscle regenerative process, focusing on the remodeling of connective tissue of…”
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Leucine Supplementation Prevents the Development of Skeletal Muscle Dysfunction in a Rat Model of HFpEF by Alves, Paula Ketilly Nascimento, Schauer, Antje, Augstein, Antje, Prieto Jarabo, Maria-Elisa, Männel, Anita, Barthel, Peggy, Vahle, Beatrice, Moriscot, Anselmo S, Linke, Axel, Adams, Volker

“…Heart failure with preserved ejection fraction (HFpEF) is associated with exercise intolerance due to alterations in the skeletal muscle (SKM). Leucine…”
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Leucine supplementation improves regeneration of skeletal muscles from old rats by Pereira, Marcelo G., Silva, Meiricris T., da Cunha, Fernanda M., Moriscot, Anselmo S., Aoki, Marcelo S., Miyabara, Elen H.

“…The decreased regenerative capacity of old skeletal muscles involves disrupted turnover of proteins. This study investigated whether leucine supplementation in…”
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Effect of bench press exercise intensity on muscle soreness and inflammatory mediators by Uchida, Marco C., Nosaka, Ken, Ugrinowitsch, Carlos, Yamashita, Alex, Martins, Eivor, Moriscot, Anselmo S., Aoki, Marcelo S.

“…This study compared four different intensities of a bench press exercise for muscle soreness, creatine kinase activity, interleukin (IL)-1β, IL-6, tumor…”
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Leucine attenuates skeletal muscle wasting via inhibition of ubiquitin ligases by Baptista, Igor L., Leal, Marcelo L., Artioli, Guilherme G., Aoki, Marcelo S., Fiamoncini, Jarlei, Turri, Antonio O., Curi, Rui, Miyabara, Elen H., Moriscot, Anselmo S.

“…The aim of this study was to assess the effect of leucine supplementation on elements of the ubiquitin–proteasome system (UPS) in rat skeletal muscle during…”
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Glutamine supplementation stimulates protein-synthetic and inhibits protein-degradative signaling pathways in skeletal muscle of diabetic rats by Lambertucci, Adriana C, Lambertucci, Rafael H, Hirabara, Sandro M, Curi, Rui, Moriscot, Anselmo S, Alba-Loureiro, Tatiana C, Guimarães-Ferreira, Lucas, Levada-Pires, Adriana C, Vasconcelos, Diogo A A, Sellitti, Donald F, Pithon-Curi, Tania C

“…In this study, we investigated the effect of glutamine (Gln) supplementation on the signaling pathways regulating protein synthesis and protein degradation in…”
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FoxO3a suppression and VPS34 activity are essential to anti-atrophic effects of leucine in skeletal muscle by Baptista, Igor L., Silvestre, João G., Silva, William J., Labeit, Siegfried, Moriscot, Anselmo S.

“…Our aim is to gain insight into the mechanisms underlying the anti-atrophic effects of leucine, namely, the way that this amino acid can restrain the…”
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Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy by Adams, Volker, Gußen, Victoria, Zozulya, Sergey, Cruz, André, Moriscot, Anselmo, Linke, Axel, Labeit, Siegfried

“…Patients with malignant tumors frequently suffer during disease progression from a syndrome referred to as cancer cachexia (CaCax): CaCax includes skeletal…”
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Overexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy by Miyabara, Elen H., Nascimento, Tabata L., Rodrigues, Débora C., Moriscot, Anselmo S., Davila, Wilmer F., AitMou, Younss, deTombe, Pieter P., Mestril, Ruben

“…Heat shock proteins play a key regulatory role in cellular defense. To investigate the role of the inducible 70-kDa heat shock protein (HSP70) in skeletal…”
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Leucine Supplementation Decreases HDAC4 Expression and Nuclear Localization in Skeletal Muscle Fiber of Rats Submitted to Hindlimb Immobilization by Alves, Paula K N, Cruz, André, Silva, William J, Labeit, Siegfried, Moriscot, Anselmo S

“…In this study we surveyed a rat skeletal muscle RNA-Seq for genes that are induced by hindlimb immobilization and, in turn, become attenuated by leucine…”
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