Search Results - "Morio, Hanae"

Development, Characterization and Potential Applications of a Multicellular Spheroidal Human Blood–Brain Barrier Model Integrating Three Conditionally Immortalized Cell Lines by Kitamura, Keita, Umehara, Kenta, Ito, Ryo, Yamaura, Yoshiyuki, Komori, Takafumi, Morio, Hanae, Akita, Hidetaka, Furihata, Tomomi

“…In vitro blood–brain barrier (BBB) models are essential research tools for use in developing brain-targeted drugs and understanding the physiological and…”
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JPH203, a newly developed anti-cancer drug, shows a preincubation inhibitory effect on L-type amino acid transporter 1 function by Okunushi, Kentaro, Furihata, Tomomi, Morio, Hanae, Muto, Yasuhide, Higuchi, Kosuke, Kaneko, Meika, Otsuka, Yusuke, Ohno, Yuta, Watanabe, Yasuhiro, Reien, Yoshie, Nakagawa, Kiyoshi, Sakamoto, Shinichi, Wakashin, Hidefumi, Shimojo, Naoki, Anzai, Naohiko

“…JPH203 is a novel anti-cancer drug targeting L-type amino acid transporter 1 (LAT1), which plays a primary role in the uptake of essential amino acids in tumor…”
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Different Response Profiles of Gastrointestinal Cancer Cells to an L-Type Amino Acid Transporter Inhibitor, JPH203 by Muto, Yasuhide, Furihata, Tomomi, Kaneko, Meika, Higuchi, Kosuke, Okunushi, Kentaro, Morio, Hanae, Reien, Yoshie, Uesato, Masaya, Matsubara, Hisahiro, Anzai, Naohiko

“…L-type amino acid transporter 1 (LAT1) is a promising molecular target for cancer therapy. The present study aimed to characterize the anti-cancer effects of…”
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In Vitro-In Vivo Correlation of Blood–Brain Barrier Permeability of Drugs: A Feasibility Study Towards Development of Prediction Methods for Brain Drug Concentration in Humans by Ito, Ryo, Morio, Hanae, Baba, Tomoyo, Sakaguchi, Yasuyuki, Wakayama, Naomi, Isogai, Ryuto, Yamaura, Yoshiyuki, Komori, Takafumi, Furihata, Tomomi

“…Purpose In vitro human blood–brain barrier (BBB) models in combination with central nervous system-physiologically based pharmacokinetic (CNS-PBPK) modeling,…”
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Effects of islatravir (4′-ethynyl-2-fluoro-2′-deoxyadenosine or EFdA) on renal tubular cells and islatravir's interactions with organic anion transporters by Kaneko, Meika, Reien, Yoshie, Morio, Hanae, Fukuuchi, Tomoko, Kaneko, Kiyoko, Hirayama, Yuri, Hashimoto, Hirofumi, Kuwata, Nobuyo, Mitsuya, Hiroaki, Anzai, Naohiko

“…Islatravir (ISL; 4′-ethynyl-2-fluoro-2′-deoxyadenosine or EFdA) is a novel reverse transcriptase translocation inhibitor and has a unique structure and high…”
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Transferrin receptor-targeting property of pabinafusp alfa facilitates its uptake by various types of human brain-derived cells in vitro by Fukatsu, Tomoki, Morio, Hanae, Furihata, Tomomi, Sonoda, Hiroyuki

“…Pabinafusp alfa, which is an anti-mucopolysaccharidosis II drug, consists of iduronate-2-sulfatase (IDS) genetically fused with an anti-transferrin receptor…”
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Cancer-Type OATP1B3 mRNA in Extracellular Vesicles as a Promising Candidate for a Serum-Based Colorectal Cancer Biomarker by Morio, Hanae, Sun, Yuchen, Harada, Manami, Ide, Hideyuki, Shimozato, Osamu, Zhou, Xujia, Higashi, Kenjirou, Yuki, Ryuzaburo, Yamaguchi, Naoto, Hofbauer, Josefina Piñón, Guttmann-Gruber, Christina, Anzai, Naohiko, Akita, Hidetaka, Chiba, Kan, Furihata, Tomomi

“…Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA is a variant isoform of the liver-type OATP1B3. Because Ct-OATP1B3 mRNA shows an…”
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Human Immortalized Cell-Based Blood–Brain Barrier Spheroid Models Offer an Evaluation Tool for the Brain Penetration Properties of Macromolecules by Kitamura, Keita, Okamoto, Ayaka, Morio, Hanae, Isogai, Ryuto, Ito, Ryo, Yamaura, Yoshiyuki, Izumi, Saki, Komori, Takafumi, Ito, Shingo, Ohtsuki, Sumio, Akita, Hidetaka, Furihata, Tomomi

“…Blood–brain barrier (BBB)-permeable middle- or macromolecules (middle/macromolecules) have recently attracted significant attention as new drug delivery…”
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Protein kinase C activation upregulates human L-type amino acid transporter 2 function by Morio, Hanae, Reien, Yoshie, Hirayama, Yuri, Hashimoto, Hirofumi, Anzai, Naohiko

“…L-type amino acid transporter 2 (LAT2) is a Na -independent neutral amino acid transporter, whose function regulation system remains unclarified. Since protein…”
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Development of a New Conditionally Immortalized Human Liver Sinusoidal Endothelial Cells by Zhu, Meiyan, Koibuchi, Akira, Ide, Hideyuki, Morio, Hanae, Shibuya, Minaka, Kamiichi, Atsuko, Tsubota, Akihito, Anzai, Naohiko, Akita, Hidetaka, Chiba, Kan, Furihata, Tomomi

“…Liver sinusoidal endothelial cells (LSECs), which are specialized endothelial cells that line liver sinusoids, have been reported to participate in a variety…”
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Differentiated HASTR/ci35 cells: A promising in vitro human astrocyte model for facilitating CNS drug development studies by Kitamura, Keita, Ito, Ryo, Umehara, Kenta, Morio, Hanae, Saito, Kosuke, Suzuki, Shota, Hashimoto, Mari, Saito, Yoshiro, Anzai, Naohiko, Akita, Hidetaka, Chiba, Kan, Furihata, Tomomi

“…Astrocytes have shown longstanding promise as therapeutic targets for various central nervous system diseases. To facilitate drug development targeting…”
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Generation of a Human Conditionally Immortalized Cell-based Multicellular Spheroidal Blood-Brain Barrier Model for Permeability Evaluation of Macromolecules by Isogai, Ryuto, Morio, Hanae, Okamoto, Ayaka, Kitamura, Keita, Furihata, Tomomi

“…There is an urgent need for the development of brain drug delivery carriers based on middle-sized or macromolecules, to which blood-brain barrier (BBB) models…”
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Evaluating a Targeted Cancer Therapy Approach Mediated by RNA trans -Splicing In Vitro and in a Xenograft Model for Epidermolysis Bullosa-Associated Skin Cancer by Woess, Katharina, Sun, Yuchen, Morio, Hanae, Stierschneider, Anna, Kaufmann, Anna, Hainzl, Stefan, Trattner, Lisa, Kocher, Thomas, Tockner, Birgit, Leb-Reichl, Victoria, Steiner, Markus, Brachtl, Gabriele, South, Andrew P, Bauer, Johann W, Reichelt, Julia, Furihata, Tomomi, Wally, Verena, Koller, Ulrich, Piñón Hofbauer, Josefina, Guttmann-Gruber, Christina

“…Conventional anti-cancer therapies based on chemo- and/or radiotherapy represent highly effective means to kill cancer cells but lack tumor specificity and,…”
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Cancer-type organic anion transporting polypeptide 1B3 is a target for cancer suicide gene therapy using RNA trans-splicing technology by Sun, Yuchen, Piñón Hofbauer, Josefina, Harada, Manami, Wöss, Katharina, Koller, Ulrich, Morio, Hanae, Stierschneider, Anna, Kitamura, Keita, Hashimoto, Mari, Chiba, Kan, Akita, Hidetaka, Anzai, Naohiko, Reichelt, Julia, Bauer, Johann W., Guttmann-Gruber, Christina, Furihata, Tomomi

“…Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) has been identified as a cancer-specific transcript in various solid cancers, including…”
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Differential inhibition features of direct-acting anti-hepatitis C virus agents against human organic anion transporting polypeptide 2B1 by Furihata, Tomomi, Fu, Zhongguo, Suzuki, Yuki, Matsumoto, Shogo, Morio, Hanae, Tsubota, Akihito, Matsumoto, Sayaka, Chiba, Kan

“…Highlights • Simeprevir (SMV) and asunaprevir (ASV) are potent inhibitors of OATP2B1. • SMV and ASV also show long-lasting OATP2B1 inhibitory effects. • The…”
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Human organic anion transporter 2 is an entecavir, but not tenofovir, transporter by Furihata, Tomomi, Morio, Hanae, Zhu, Meiyan, Suzuki, Yuki, Ide, Hideyuki, Tsubota, Akihito, Fu, Zhongguo, Anzai, Naohiko, Chiba, Kan

“…Entecavir (ETV) and tenofovir (TFV) are essential nucleoside analogues in current hepatitis B virus (HBV) treatments. Since these drugs target the HBV…”
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A new immortalized human liver sinusoidal endothelial cell line: Establishment, characterization, and application potential to development of in vitro human liver models by Zhu, Meiyan, Furihata, Tomomi, Koibuchi, Akira, Ide, Hideyuki, Morio, Hanae, Shibuya, Minaka, Kamiichi, Atsuko, Akita, Hidetaka, Chiba, Kan

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Development, characterization and potential applications of a multicellular spheroidal human blood-brain barrier model integrating three conditionally immortalized cell lines by Kitamura, Keita, Umehara, Kenta, Ito, Ryo, Yamaura, Yoshiyuki, Komori, Takafumi, Morio, Hanae, Akita, Hidetaka, Furihata, Tomomi

“…In vitro blood-brain barrier (BBB) models are essential research tools for use in developing brain-targeted drugs and understanding the physiological and…”
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Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation by Ohe, Tomoyuki, Umezawa, Ryutaro, Kitagawara, Yumina, Yasuda, Daisuke, Takahashi, Kyoko, Nakamura, Shigeo, Abe, Akiko, Sekine, Shuichi, Ito, Kousei, Okunushi, Kentaro, Morio, Hanae, Furihata, Tomomi, Anzai, Naohiko, Mashino, Tadahiko

“…[Display omitted] •Synthesis of a novel set of benzbromarone derivatives.•Reduced cytotoxicity in mouse hepatocytes.•Attenuated mitochondrial toxicity with…”
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