Search Results - "Morinaga, Gaku"

Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue by Kawatou, Masahide, Masumoto, Hidetoshi, Fukushima, Hiroyuki, Morinaga, Gaku, Sakata, Ryuzo, Ashihara, Takashi, Yamashita, Jun K.

“…Torsade de Pointes (TdP) is a lethal arrhythmia that is often drug-induced, thus there is an urgent need for development of models to test or predict the drug…”
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Development and Validation of a Proteomic Correlation Profiling Technique to Detect and Identify Enzymes Involved in Metabolism of Drugs of Concern by Kudo, Takashi, Hashiba, Shiori, Fukami, Tatsuki, Morinaga, Gaku, Nishiyama, Kotaro, Ichida, Hiroyuki, Hirosawa, Keiya, Matsui, Akiko, Ishiguro, Naoki, Nakajima, Miki

“…To predict the variation of pharmacological or toxicological effect caused by pharmacokinetic variance, it is important to be able to detect previously unknown…”
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Regional Transcriptomics and Proteomics of Pharmacokinetics-Related Genes in Human Intestine by Murata, Michika, Fujioka, Hijiri, Yokota, Jumpei, Okada, Kentaro, Yamashita, Tomoki, Hirayama, Daisuke, Kawakami, Kentaro, Morinaga, Gaku, Saito, Asami, Nakase, Hiroshi, Kishimoto, Wataru, Mizuguchi, Hiroyuki

“…The intestine is an organ responsible for the absorption and metabolism of orally administered drugs. To predict pharmacokinetics behavior in the small…”
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Characterization of Enzymes Involved in Nintedanib Metabolism in Humans by Nakashima, Shimon, Sato, Rei, Fukami, Tatsuki, Kudo, Takashi, Hashiba, Shiori, Morinaga, Gaku, Nakano, Masataka, Ludwig-Schwellinger, Eva, Matsui, Akiko, Ishiguro, Naoki, Ebner, Thomas, Nakajima, Miki

“…Nintedanib, which is used to treat idiopathic pulmonary fibrosis and non-small cell lung cancer, is metabolized to a pharmacologically inactive carboxylate…”
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Improvement of protein expression profile in three-dimensional renal proximal tubular epithelial cell spheroids selected based on OAT1 gene expression: a potential in vitro tool for evaluating human renal proximal tubular toxicity and drug disposition by Ishiguro, Naoki, Takahashi, Etsushi, Arakawa, Hiroshi, Saito, Asami, Kitagawa, Fumihiko, Kondo, Masayuki, Morinaga, Gaku, Takatani, Masahito, Takahashi, Ryo, Kudo, Takashi, Mae, Shin-Ichi, Kadoguchi, Moeno, Higuchi, Daichi, Nakazono, Yuya, Tamai, Ikumi, Osafune, Kenji, Jimbo, Yoichi

“…The proximal tubule plays an important role in the kidney and is a major site of drug interaction and toxicity. Analysis of kidney toxicity via in vitro assays…”
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Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes by Schaefer, Michelle, Morinaga, Gaku, Matsui, Akiko, Schänzle, Gerhard, Bischoff, Daniel, Süssmuth, Roderich D.

“…Deficient functional expression of drug transporters incapacitates most hepatic cell lines as a reliable tool for evaluating transporter-mediated drug-drug…”
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Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research by Yamashita, Tomoki, Inui, Tatsuya, Yokota, Jumpei, Kawakami, Kentaro, Morinaga, Gaku, Takatani, Masahito, Hirayama, Daisuke, Nomoto, Ryuga, Ito, Kohei, Cui, Yunhai, Ruez, Stephanie, Harada, Kazuo, Kishimoto, Wataru, Nakase, Hiroshi, Mizuguchi, Hiroyuki

“…The human small intestine is the key organ for absorption, metabolism, and excretion of orally administered drugs. To preclinically predict these reactions in…”
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P117 - Impact of culture conditions on functional expression of major drug metabolizing enzymes and transporters in long-term UPCYTE® hepatocyte culture by Schaefer, Michelle, Morinaga, Gaku, Saito, Asami, Matsui, Akiko, Schänzle, Gerhard, Bischoff, Daniel, Klinder, Klaus, Süssmuth, Roderich D.

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Metabolic capability of upcyte human hepatocytes in long-term sandwich culture and utility for clearance prediction by Schaefer, Michelle, Matsui, Akiko, Morinaga, Gaku, Saito, Asami, Suzuki, Shinobu, Schänzle, Gerhard, Bischoff, Daniel, Süssmuth, Roderich D.

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Effects of Mutations of ABCA1 in the First Extracellular Domain on Subcellular Trafficking and ATP Binding/Hydrolysis by Tanaka, Arowu R, Abe-Dohmae, Sumiko, Ohnishi, Tomohiro, Aoki, Ryo, Morinaga, Gaku, Okuhira, Kei-ichiro, Ikeda, Yuika, Kano, Fumi, Matsuo, Michinori, Kioka, Noriyuki, Amachi, Teruo, Murata, Masayuki, Yokoyama, Shinji, Ueda, Kazumitsu

“…ABCA1 mediates release of cellular cholesterol and phospholipid to form high density lipoprotein (HDL). The three different mutants in the first extracellular…”
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Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine by Hirosawa, Keiya, Fujioka, Hijiri, Morinaga, Gaku, Fukami, Tatsuki, Ishiguro, Naoki, Kishimoto, Wataru, Nakase, Hiroshi, Mizuguchi, Hiroyuki, Nakajima, Miki

“…Enzymes catalyzing the reduction reaction of xenobiotics are mainly members of the aldo-keto reductase (AKR) and short-chain dehydrogenase/reductase (SDR)…”
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Identification of HSD17B12 as an enzyme catalyzing drug reduction reactions through investigation of nabumetone metabolism by Ichida, Hiroyuki, Fukami, Tatsuki, Kudo, Takashi, Mishiro, Kenji, Takano, Shiori, Nakano, Masataka, Morinaga, Gaku, Matsui, Akiko, Ishiguro, Naoki, Nakajima, Miki

“…Nabumetone, a nonsteroidal anti-inflammatory prodrug, is converted to a pharmacologically active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA); however,…”
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Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic 2D Sandwich-Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes by Schaefer, Michelle, Morinaga, Gaku, Matsui, Akiko, Schanzle, Gerhard, Bischoff, Daniel, Sussmuth, Roderich D

“…Deficient functional expression of drug transporters incapacitates most hepatic cell lines as reliable tool for evaluating transporter-mediated drug-drug…”
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Abstract 14033: Development of a Drug-induced Spiral Wave Re-entrant Tachycardia Model in Human Induced Pluripotent Stem Cell-derived Mini-3D Cardiac Tissue Sheets by Kawatou, Masahide, Masumoto, Hidetoshi, Fukushima, Hiroyuki, Morinaga, Gaku, Minakata, Kenji, Ikeda, Tadashi, Sakata, Ryuzo, Ashihara, Takashi, Sekino, Yuko, Yamashita, Jun K

“…BackgroundsLife-threatening arrhythmias are critical issues in clinical health care. The development of human induced pluripotent stem cell (hiPSC)-derived…”
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Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/ hydrolysis by Tanaka, Arowu R., Abe-Dohmae, Sumiko, Ohnishi, Tomohiro, Aoki, Ryo, Morinaga, Gaku, Okuhira, Kei-ichiro, Ikeda, Yuika, Kano, Fumi, Matsuo, Michinori, Kioka, Noriyuki, Amachi, Teruo, Murata, Masayuki, Yokoyama, Shinji, Ueda, Kazumitsu

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