Search Results - "Morin, Ryan"

Cell-free DNA (cfDNA): Clinical Significance and Utility in Cancer Shaped By Emerging Technologies by Volik, Stanislav, Alcaide, Miguel, Morin, Ryan D, Collins, Colin

“…Precision oncology is predicated upon the ability to detect specific actionable genomic alterations and to monitor their adaptive evolution during treatment to…”
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Molecular profiling in diffuse large B‐cell lymphoma: why so many types of subtypes? by Morin, Ryan D., Arthur, Sarah E., Hodson, Daniel J.

“…Summary The term diffuse large B‐cell lymphoma (DLBCL) includes a heterogeneous collection of biologically distinct tumours. This heterogeneity currently…”
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A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications by Wright, George W., Huang, Da Wei, Phelan, James D., Coulibaly, Zana A., Roulland, Sandrine, Young, Ryan M., Wang, James Q., Schmitz, Roland, Morin, Ryan D., Tang, Jeffrey, Jiang, Aixiang, Bagaev, Aleksander, Plotnikova, Olga, Kotlov, Nikita, Johnson, Calvin A., Wilson, Wyndham H., Scott, David W., Staudt, Louis M.

“…The development of precision medicine approaches for diffuse large B cell lymphoma (DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical…”
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Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma by Ennishi, Daisuke, Jiang, Aixiang, Boyle, Merrill, Collinge, Brett, Grande, Bruno M, Ben-Neriah, Susana, Rushton, Christopher, Tang, Jeffrey, Thomas, Nicole, Slack, Graham W, Farinha, Pedro, Takata, Katsuyoshi, Miyata-Takata, Tomoko, Craig, Jeffrey, Mottok, Anja, Meissner, Barbara, Saberi, Saeed, Bashashati, Ali, Villa, Diego, Savage, Kerry J, Sehn, Laurie H, Kridel, Robert, Mungall, Andrew J, Marra, Marco A, Shah, Sohrab P, Steidl, Christian, Connors, Joseph M, Gascoyne, Randy D, Morin, Ryan D, Scott, David W

“…High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to…”
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Concerning data inconsistencies in Burkitt lymphoma genome study by Rushton, Christopher K., Dreval, Kostiantyn, Morin, Ryan D.

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Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition by Ennishi, Daisuke, Takata, Katsuyoshi, Béguelin, Wendy, Duns, Gerben, Mottok, Anja, Farinha, Pedro, Bashashati, Ali, Saberi, Saeed, Boyle, Merrill, Meissner, Barbara, Ben-Neriah, Susana, Woolcock, Bruce W, Telenius, Adèle, Lai, Daniel, Teater, Matt, Kridel, Robert, Savage, Kerry J, Sehn, Laurie H, Morin, Ryan D, Marra, Marco A, Shah, Sohrab P, Connors, Joseph M, Gascoyne, Randy D, Scott, David W, Melnick, Ari M, Steidl, Christian

“…We performed a genomic, transcriptomic, and immunophenotypic study of 347 patients with diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis…”
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Minimal information for reporting a genomics experiment by Dreval, Kostiantyn, Boutros, Paul C., Morin, Ryan D.

“…[Display omitted] Exome and genome sequencing has facilitated the identification of hundreds of genes and other regions that are recurrently mutated in…”
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Circulating Tumor Cells (CTC) and Cell-Free DNA (cfDNA) Workshop 2016: Scientific Opportunities and Logistics for Cancer Clinical Trial Incorporation by Lowes, Lori E, Bratman, Scott V, Dittamore, Ryan, Done, Susan, Kelley, Shana O, Mai, Sabine, Morin, Ryan D, Wyatt, Alexander W, Allan, Alison L

“…Despite the identification of circulating tumor cells (CTCs) and cell-free DNA (cfDNA) as potential blood-based biomarkers capable of providing prognostic and…”
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Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas by Vallois, David, Dobay, Maria Pamela D., Morin, Ryan D., Lemonnier, François, Missiaglia, Edoardo, Juilland, Mélanie, Iwaszkiewicz, Justyna, Fataccioli, Virginie, Bisig, Bettina, Roberti, Annalisa, Grewal, Jasleen, Bruneau, Julie, Fabiani, Bettina, Martin, Antoine, Bonnet, Christophe, Michielin, Olivier, Jais, Jean-Philippe, Figeac, Martin, Bernard, Olivier A., Delorenzi, Mauro, Haioun, Corinne, Tournilhac, Olivier, Thome, Margot, Gascoyne, Randy D., Gaulard, Philippe, de Leval, Laurence

“…Angioimmunoblastic T-cell lymphoma (AITL) and other lymphomas derived from follicular T-helper cells (TFH) represent a large proportion of peripheral T-cell…”
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Super-enhancer hypermutation alters oncogene expression in B cell lymphoma by Bal, Elodie, Kumar, Rahul, Hadigol, Mohammad, Holmes, Antony B., Hilton, Laura K., Loh, Jui Wan, Dreval, Kostiantyn, Wong, Jasper C. H., Vlasevska, Sofija, Corinaldesi, Clarissa, Soni, Rajesh Kumar, Basso, Katia, Morin, Ryan D., Khiabanian, Hossein, Pasqualucci, Laura, Dalla-Favera, Riccardo

“…Diffuse large B cell lymphoma (DLBCL) is the most common B cell non-Hodgkin lymphoma and remains incurable in around 40% of patients. Efforts to sequence the…”
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DLBCL subclassification: divide and conquer? by Morin, Ryan D., Scott, David W.

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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma by Morin, Ryan D., Mendez-Lago, Maria, Mungall, Andrew J., Goya, Rodrigo, Mungall, Karen L., Corbett, Richard D., Johnson, Nathalie A., Severson, Tesa M., Chiu, Readman, Field, Matthew, Jackman, Shaun, Krzywinski, Martin, Scott, David W., Trinh, Diane L., Tamura-Wells, Jessica, Li, Sa, Firme, Marlo R., Rogic, Sanja, Griffith, Malachi, Chan, Susanna, Yakovenko, Oleksandr, Meyer, Irmtraud M., Zhao, Eric Y., Smailus, Duane, Moksa, Michelle, Chittaranjan, Suganthi, Rimsza, Lisa, Brooks-Wilson, Angela, Spinelli, John J., Ben-Neriah, Susana, Meissner, Barbara, Woolcock, Bruce, Boyle, Merrill, McDonald, Helen, Tam, Angela, Zhao, Yongjun, Delaney, Allen, Zeng, Thomas, Tse, Kane, Butterfield, Yaron, Birol, Inanç, Holt, Rob, Schein, Jacqueline, Horsman, Douglas E., Moore, Richard, Jones, Steven J. M., Connors, Joseph M., Hirst, Martin, Gascoyne, Randy D., Marra, Marco A.

“…Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched…”
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Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody by Gebremeskel, Simon, Schanin, Julia, Coyle, Krysta M, Butuci, Melina, Luu, Thuy, Brock, Emily C, Xu, Alan, Wong, Alan, Leung, John, Korver, Wouter, Morin, Ryan D, Schleimer, Robert P, Bochner, Bruce S, Youngblood, Bradford A

“…Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors…”
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Profiling the HeLa S3 transcriptome using randomly primed cDNA and massively parallel short-read sequencing by Morin, Ryan, Bainbridge, Matthew, Fejes, Anthony, Hirst, Martin, Krzywinski, Martin, Pugh, Trevor, McDonald, Helen, Varhol, Richard, Jones, Steven, Marra, Marco

“…Sequence-based methods for transcriptome characterization have typically relied on generation of either serial analysis of gene expression tags or expressed…”
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The double-hit signature identifies double-hit diffuse large B-cell lymphoma with genetic events cryptic to FISH by Hilton, Laura K., Tang, Jeffrey, Ben-Neriah, Susana, Alcaide, Miguel, Jiang, Aixiang, Grande, Bruno M., Rushton, Christopher K., Boyle, Merrill, Meissner, Barbara, Scott, David W., Morin, Ryan D.

“…High-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/THs) include a group of diffuse large B-cell lymphomas (DLBCLs) with inferior…”
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Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells by Morin, Ryan D, O'Connor, Michael D, Griffith, Malachi, Kuchenbauer, Florian, Delaney, Allen, Prabhu, Anna-Liisa, Zhao, Yongjun, McDonald, Helen, Zeng, Thomas, Hirst, Martin, Eaves, Connie J, Marra, Marco A

“…MicroRNAs (miRNAs) are emerging as important, albeit poorly characterized, regulators of biological processes. Key to further elucidation of their roles is the…”
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Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma by Kridel, Robert, Meissner, Barbara, Rogic, Sanja, Boyle, Merrill, Telenius, Adele, Woolcock, Bruce, Gunawardana, Jay, Jenkins, Catherine E., Cochrane, Chris, Ben-Neriah, Susana, Tan, King, Morin, Ryan D., Opat, Stephen, Sehn, Laurie H., Connors, Joseph M., Marra, Marco A., Weng, Andrew P., Steidl, Christian, Gascoyne, Randy D.

“…Mantle cell lymphoma (MCL), an aggressive subtype of non-Hodgkin lymphoma, is characterized by the hallmark translocation t(11;14)(q13;q32) and the resulting…”
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Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas by Morin, Ryan D, Assouline, Sarit, Alcaide, Miguel, Mohajeri, Arezoo, Johnston, Rebecca L, Chong, Lauren, Grewal, Jasleen, Yu, Stephen, Fornika, Daniel, Bushell, Kevin, Nielsen, Torsten Holm, Petrogiannis-Haliotis, Tina, Crump, Michael, Tosikyan, Axel, Grande, Bruno M, MacDonald, David, Rousseau, Caroline, Bayat, Maryam, Sesques, Pierre, Froment, Remi, Albuquerque, Marco, Monczak, Yury, Oros, Kathleen Klein, Greenwood, Celia, Riazalhosseini, Yasser, Arseneault, Madeleine, Camlioglu, Errol, Constantin, André, Pan-Hammarstrom, Qiang, Peng, Roujun, Mann, Koren K, Johnson, Nathalie A

“…Relapsed or refractory diffuse large B-cell lymphoma (rrDLBCL) is fatal in 90% of patients, and yet little is known about its biology. Using exome sequencing,…”
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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation by Yap, Damian B., Chu, Justin, Berg, Tobias, Schapira, Matthieu, Cheng, S.-W. Grace, Moradian, Annie, Morin, Ryan D., Mungall, Andrew J., Meissner, Barbara, Boyle, Merrill, Marquez, Victor E., Marra, Marco A., Gascoyne, Randy D., Humphries, R. Keith, Arrowsmith, Cheryl H., Morin, Gregg B., Aparicio, Samuel A.J.R.

“…Next-generation sequencing of follicular lymphoma and diffuse-large B-cell lymphoma has revealed frequent somatic, heterozygous Y641 mutations in the histone…”
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Biological heterogeneity in diffuse large B-cell lymphoma by Hilton, Laura K., Scott, David W., Morin, Ryan D.

“…Diffuse large B-cell lymphoma (DLBCL) is heterogeneous both in clinical outcomes and the underlying disease biology. Over the last 2 decades, several different…”
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