Search Results - "Morimoto, RI"

Autophagy in healthy aging and disease by Aman, Yahyah, Schmauck-Medina, Tomas, Hansen, Malene, Morimoto, Richard I, Simon, Anna Katharina, Bjedov, Ivana, Palikaras, Konstantinos, Simonsen, Anne, Johansen, Terje, Tavernarakis, Nektarios, Rubinsztein, David C, Partridge, Linda, Kroemer, Guido, Labbadia, John, Fang, Evandro F

“…Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via…”
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Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones by Morley, James F, Morimoto, Richard I

“…The correlation between longevity and stress resistance observed in long-lived mutant animals suggests that the ability to sense and respond to environmental…”
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Heat Shock Response Modulators as Therapeutic Tools for Diseases of Protein Conformation by Westerheide, Sandy D., Morimoto, Richard I.

“…The disruption of protein folding quality control results in the accumulation of a non-native protein species that can form oligomers, aggregates, and…”
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Molecular chaperones and the stress of oncogenesis by Mosser, Dick D, Morimoto, Richard I

“…Protein-damaging stresses induce the expression of 'heat-shock proteins', which have essential roles in protecting cells from the potentially lethal effects of…”
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Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators by Morimoto, R I

“…Our cells and tissues are challenged constantly by exposure to extreme conditions that cause acute and chronic stress. Consequently, survival has necessitated…”
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Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases by Gidalevitz, Tali, Ben-Zvi, Anat, Ho, Kim H, Brignull, Heather R, Morimoto, Richard I

“…Numerous human diseases are associated with the chronic expression of misfolded and aggregation-prone proteins. The expansion of polyglutamine residues in…”
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Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins by Nollen, Ellen A A, Morimoto, Richard I

“…Heat shock proteins interact with multiple key components of signaling pathways that regulate growth and development. The molecular relationships between heat…”
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Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death by Jolly, Caroline, Morimoto, Richard I.

“…Exposure of cells to conditions of environmental stress—including heat shock, oxidative stress, heavy metals, or pathologic conditions, such as ischemia and…”
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The Threshold for Polyglutamine-Expansion Protein Aggregation and Cellular Toxicity is Dynamic and Influenced by Aging in Caenorhabditis elegans by Morley, James F., Brignull, Heather R., Weyers, Jill J., Morimoto, Richard I.

“…Studies of the mutant gene in Huntington's disease, and for eight related neurodegenerative disorders, have identified polyglutamine (polyQ) expansions as a…”
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Inefficient degradation of truncated polyglutamine proteins by the proteasome by Holmberg, Carina I, Staniszewski, Kristine E, Mensah, Kwame N, Matouschek, Andreas, Morimoto, Richard I

“…Accumulation of mutant proteins into misfolded species and aggregates is characteristic for diverse neurodegenerative diseases including the polyglutamine…”
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Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain by Sriram, M, Osipiuk, J, Freeman, BC, Morimoto, RI, Joachimiak, A

“…Background: The 70 kDa heat shock proteins (Hsp70) are a family of molecular chaperones, which promote protein folding and participate in many cellular…”
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Dynamic Remodeling of Transcription Complexes by Molecular Chaperones by Morimoto, Richard I.

“…The assembly and disassembly of macromolecular transcription complexes represents a key step in the regulation of gene expression. For inducible responses to…”
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Triptolide, an Inhibitor of the Human Heat Shock Response That Enhances Stress-induced Cell Death by Westerheide, Sandy D., Kawahara, Tiara L.A., Orton, Kai, Morimoto, Richard I.

“…Molecular chaperones, inducible by heat shock and a variety of other stresses, have critical roles in protein homeostasis, balancing cell stress with…”
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Celastrols as Inducers of the Heat Shock Response and Cytoprotection[boxs] by Westerheide, Sandy D., Bosman, Joshua D., Mbadugha, Bessie N.A., Kawahara, Tiara L.A., Matsumoto, Gen, Kim, Soojin, Gu, Wenxin, Devlin, John P., Silverman, Richard B., Morimoto, Richard I.

“…Alterations in protein folding and the regulation of conformational states have become increasingly important to the functionality of key molecules in…”
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Genome-Wide RNA Interference Screen Identifies Previously Undescribed Regulators of Polyglutamine Aggregation by Ellen A. A. Nollen, Garcia, Susana M., van Haaften, Gijs, Kim, Soojin, Chavez, Alejandro, Morimoto, Richard I., Ronald H. A. Plasterk, Horwich, A. L.

“…Protein misfolding and the formation of aggregates are increasingly recognized components of the pathology of human genetic disease and hallmarks of many…”
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Huntingtin and Mutant SOD1 Form Aggregate Structures with Distinct Molecular Properties in Human Cells by Matsumoto, Gen, Kim, Soojin, Morimoto, Richard I.

“…Expression of many proteins associated with neurodegenerative disease results in the appearance of misfolded species that readily adopt alternate folded…”
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Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth by Morimoto, Richard I, Song, Jaewhan, Takeda, Masahiro

“…Survival after stress requires the precise orchestration of cell-signalling events to ensure that biosynthetic processes are alerted and cell survival pathways…”
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Molecular chaperones as HSF1-specific transcriptional repressors by Shi, Y, Mosser, D D, Morimoto, R I

“…The rapid yet transient transcriptional activation of heat shock genes is mediated by the reversible conversion of HSF1 from an inert negatively regulated…”
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Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome by Beere, Helen M, Wolf, Beni B, Cain, Kelvin, Mosser, Dick D, Mahboubi, Artin, Kuwana, Tomomi, Tailor, Pankaj, Morimoto, Richard I, Cohen, Gerald M, Green, Douglas R

“…The cellular-stress response can mediate cellular protection through expression of heat-shock protein (Hsp) 70, which can interfere with the process of…”
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Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock by Marcuccilli, CJ, Mathur, SK, Morimoto, RI, Miller, RJ

“…During periods of stress, cells depend on a transient, highly conserved, and regulated response to maintain homeostasis. This "heat shock response" is mediated…”
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