Search Results - "Morikis, Vasilios A."

Tensile force transmitted through LFA‐1 bonds mechanoregulate neutrophil inflammatory response by Morikis, Vasilios A., Masadeh, Eman, Simon, Scott I.

“…Recruitment of leukocytes to sites of acute inflammation is guided by spatial and temporal cues that ensure appropriate cell numbers infiltrate the tissue at…”
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Neutrophil Mechanosignaling Promotes Integrin Engagement With Endothelial Cells and Motility Within Inflamed Vessels by Morikis, Vasilios A, Simon, Scott I

“…Neutrophils are the most motile of mammalian cells, a feature that enables them to protect the host against the rapid spread of pathogens from tissue into the…”
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Targeting Neutrophil Adhesive Events to Address Vaso-Occlusive Crisis in Sickle Cell Patients by Morikis, Vasilios A, Hernandez, Alfredo A, Magnani, John L, Sperandio, Markus, Simon, Scott I

“…Neutrophils are essential to protect the host against invading pathogens but can promote disease progression in sickle cell disease (SCD) by becoming adherent…”
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CagY-Dependent Regulation of Type IV Secretion in Helicobacter pylori Is Associated with Alterations in Integrin Binding by Skoog, Emma C, Morikis, Vasilios A, Martin, Miriam E, Foster, Greg A, Cai, Lucy P, Hansen, Lori M, Li, Beibei, Gaddy, Jennifer A, Simon, Scott I, Solnick, Jay V

“…Strains of that cause ulcer or gastric cancer typically express a type IV secretion system (T4SS) encoded by the pathogenicity island ( PAI). CagY is an…”
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Functional analysis of recurrent CDC20 promoter variants in human melanoma by Godoy, Paula M., Oyedeji, Abimbola, Mudd, Jacqueline L., Morikis, Vasilios A., Zarov, Anna P., Longmore, Gregory D., Fields, Ryan C., Kaufman, Charles K.

“…Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate…”
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Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow by Morikis, Vasilios A., Chase, Shannon, Wun, Ted, Chaikof, Elliot L., Magnani, John L., Simon, Scott I.

“…E-selectin extends from the plasma membrane of inflamed endothelium and serves to capture leukocytes from flowing blood via long-lived catch-bonds that support…”
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Virtual Screening of Chemical Compounds for Discovery of Complement C3 Ligands by Mohan, Rohith R, Wilson, Mark, Gorham, Ronald D, Harrison, Reed E. S, Morikis, Vasilios A, Kieslich, Chris A, Orr, Asuka A, Coley, Alexis V, Tamamis, Phanourios, Morikis, Dimitrios

“…The complement system is our first line of defense against foreign pathogens, but when it is not properly regulated, complement is implicated in the pathology…”
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Kinky integrins reveal a new wrinkle in neutrophil activation by Morikis, Vasilios A, Rivara, Kathryn, Simon, Scott I

“…Discussion on the flexible kink produced in the β2‐integrin transmembrane domain blocking mechanotransduction of signals necessary for neutrophil arrest and…”
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ROR2/Wnt5a Signaling Regulates Directional Cell Migration and Early Tumor Cell Invasion in Ovarian Cancer by Grither, Whitney R, Baker, Breanna, Morikis, Vasilios A, Ilagan, Ma Xenia G, Fuh, Katherine C, Longmore, Gregory D

“…Adhesion to and clearance of the mesothelial monolayer are key early events in metastatic seeding of ovarian cancer. ROR2 is a receptor tyrosine kinase that…”
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Selectin-Targeting Peptide–Glycosaminoglycan Conjugates Modulate Neutrophil–Endothelial Interactions by Wodicka, James R., Morikis, Vasilios A., Dehghani, Tima, Simon, Scott I., Panitch, Alyssa

“…Introduction The glycocalyx is a layer of glycoproteins, proteoglycans and glycosaminoglycans that coats the luminal surface of most blood vessels. It…”
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Atrial natriuretic peptide down-regulates neutrophil recruitment on inflamed endothelium by reducing cell deformability and resistance to detachment force by Morikis, Vasilios A, Radecke, Chris, Jiang, Yanyan, Heinrich, Volkmar, Curry, Fitz-Roy, Simon, Scott I

“…Recombinant atrial natriuretic peptide (ANP) is administered in patients with acute heart failure in Japan to improve renal function and hemodynamics, but its…”
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Mechanotransduction through High-Affinity LFA-1 is a Minimum Requirement to Induce Kindlin-3/RACK1/OraI1 to Mediate Intracellular Calcium Flux and Outside-In Signaling by Morikis, Vasilios A., Simon, Scott I.

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Abstract A102: ROR2/Wnt5a signaling regulates directional cell migration and early tumor cell invasion in ovarian cancer by Grither, Whitney R., Baker, Breanna, Morikis, Vasilios A., Fuh, Katherine C., Longmore, Gregoery D

“…Abstract Adhesion to and clearance of the mesothelial monolayer are key events in the early metastatic seeding of ovarian cancer. To identify mediators of…”
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Rivipansel (GMI-1070) Inhibits E-Selectin Recognition of Sialyl LewisX Expressed on CD62L (L-selectin) and Blocks Integrin Activation and Arrest of Human Neutrophils by Simon, Scott I, Morikis, Vasilios A, Chase, Shannon, Magnani, John L

“…Introduction: Mechanical force acting on selectin bonds facilitates neutrophil (PMN) rolling and transduction of signals that subsequently activate integrins…”
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Abstract A043: Senescent CAFs modulate tumor immunity and promote breast cancer progression by Ye, Jiayu, Baer, John M., Faget, Douglas V., Morikis, Vasilios A., Ren, Qihao, Melam, Anupama, Delgado, Ana Paula, Knudsen, Erik, Witkiewicz, Agnieszka, Powers, Robert S., Longmore, Gregory D., DeNardo, David G., Stewart, Sheila A.

“…Abstract Cellular senescence is characterized by a series of markers such as p16INKA4(p16) positivity and a distinctive profile of secretory factors including…”
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