Search Results - "Morikawa, Manatsu"

Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport by Shima, Tomohiro, Morikawa, Manatsu, Kaneshiro, Junichi, Kambara, Taketoshi, Kamimura, Shinji, Yagi, Toshiki, Iwamoto, Hiroyuki, Uemura, Sotaro, Shigematsu, Hideki, Shirouzu, Mikako, Ichimura, Taro, Watanabe, Tomonobu M, Nitta, Ryo, Okada, Yasushi, Hirokawa, Nobutaka

“…Kinesin-1, the founding member of the kinesin superfamily of proteins, is known to use only a subset of microtubules for transport in living cells. This biased…”
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Autoinhibition of a Neuronal Kinesin UNC-104/KIF1A Regulates the Size and Density of Synapses by Niwa, Shinsuke, Lipton, David M., Morikawa, Manatsu, Zhao, Charles, Hirokawa, Nobutaka, Lu, Hang, Shen, Kang

“…Kinesin motor proteins transport intracellular cargoes throughout cells by hydrolyzing ATP and moving along microtubule tracks. Intramolecular autoinhibitory…”
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A neuropathy‐associated kinesin KIF1A mutation hyper‐stabilizes the motor‐neck interaction during the ATPase cycle by Morikawa, Manatsu, Jerath, Nivedita U, Ogawa, Tadayuki, Morikawa, Momo, Tanaka, Yosuke, Shy, Michael E, Zuchner, Stephan, Hirokawa, Nobutaka

“…The mechanochemical coupling of ATPase hydrolysis and conformational dynamics in kinesin motors facilitates intramolecular interaction cycles between the…”
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Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A by Wang, Doudou, Nitta, Ryo, Morikawa, Manatsu, Yajima, Hiroaki, Inoue, Shigeyuki, Shigematsu, Hideki, Kikkawa, Masahide, Hirokawa, Nobutaka

“…The kinesin-8 motor, KIF19A, accumulates at cilia tips and controls cilium length. Defective KIF19A leads to hydrocephalus and female infertility because of…”
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X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding by Morikawa, Manatsu, Yajima, Hiroaki, Nitta, Ryo, Inoue, Shigeyuki, Ogura, Toshihiko, Sato, Chikara, Hirokawa, Nobutaka

“…The molecular motor kinesin moves along microtubules using energy from ATP hydrolysis in an initial step coupled with ADP release. In neurons, kinesin‐1/KIF5C…”
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KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway by Wan, Yuansong, Morikawa, Momo, Morikawa, Manatsu, Iwata, Suguru, Naseer, Muhammad Imran, Ahmed Chaudhary, Adeel Gulzar, Tanaka, Yosuke, Hirokawa, Nobutaka

“…Epilepsy is a common neurological disease worldwide, and one of its causes is genetic abnormalities. Here, we identified a point mutation in KIF4A, a member of…”
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Oxidative stress-mediated bimodal regulation of polymorphonuclear leukocyte spreading by polyphenolic compounds by Suzuki, Kingo, Kori, Soichiro, Morikawa, Manatsu, Takagi, Ai, Namiki, Hideo

“…Pyrogallol-bearing polyphenolic compounds induce spreading of polymorphonuclear leukocytes (PMNL), although their optimal concentrations for induction of…”
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