Effects of dipeptides having a C-terminal lysine on the cholesterol 7alpha-hydroxylase mRNA level in HepG2 cells

Inducing expression of the cholesterol-catabolizing enzyme cholesterol 7alpha-hydroxylase (CYP7A1) in the liver can be an effective strategy in preventing hypercholesterolemia and atherosclerosis. We used HepG2 cells to investigate the effects of 1 mM dipeptides having a C-terminal lysine group on t...

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Bibliographic Details
Published in:	Bioscience, biotechnology, and biochemistry Vol. 71; no. 3; pp. 821 - 825
Main Authors:	Morikawa, K.(Gifu Univ. (Japan). Faculty of Applied Biological Sciences), Ishikawa, K, Kanamaru, Y, Hori, G, Nagaoka, S
Format:	Journal Article
Language:	English
Published:	England 01-03-2007
Subjects:	Amino Acids - pharmacology ARN MENSAJERO ARN MESSAGER CATABOLISM CATABOLISME CATABOLISMO Cell Line Cell Line, Tumor Cholesterol 7-alpha-Hydroxylase - metabolism Dipeptides - pharmacology FOIE Gene Expression Regulation, Enzymologic - drug effects GENERO HUMANO GENRE HUMAIN HIGADO HIPERLIPIDEMIA Humans HYPERLIPIDAEMIA HYPERLIPIDEMIE LISINA LIVER LYSINE Lysine - pharmacology MANKIND MESSENGER RNA PEPTIDE PEPTIDES PEPTIDOS RNA, Messenger - metabolism
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Summary:	Inducing expression of the cholesterol-catabolizing enzyme cholesterol 7alpha-hydroxylase (CYP7A1) in the liver can be an effective strategy in preventing hypercholesterolemia and atherosclerosis. We used HepG2 cells to investigate the effects of 1 mM dipeptides having a C-terminal lysine group on the CYP7A1 mRNA level. We found that the dipeptides Asp-Lys, Glu-Lys, and Trp-Lys significantly increased the CYP7A1 mRNA level.
Bibliography:	S20 2007006258 L50 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0916-8451 1347-6947