Search Results - "Moriguchi, Tetsuo"

A Powerful CRISPR/Cas9-Based Method for Targeted Transcriptional Activation by Katayama, Shota, Moriguchi, Tetsuo, Ohtsu, Naoki, Kondo, Toru

“…Targeted transcriptional activation of endogenous genes is important for understanding physiological transcriptional networks, synthesizing genetic circuits,…”
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Ecrg4 peptide is the ligand of multiple scavenger receptors by Moriguchi, Tetsuo, Takeda, Shuji, Iwashita, Shinzo, Enomoto, Kei, Sawamura, Tatsuya, Koshimizu, Uichi, Kondo, Toru

“…Esophageal cancer-related gene 4 ( Ecrg4 ) encodes a hormone-like peptide that is believed to be involved in a variety of physiological phenomena, including…”
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WNK1 Regulates Phosphorylation of Cation-Chloride-coupled Cotransporters via the STE20-related Kinases, SPAK and OSR1 by Moriguchi, Tetsuo, Urushiyama, Seiichi, Hisamoto, Naoki, Iemura, Shun-ichiro, Uchida, Shinichi, Natsume, Tohru, Matsumoto, Kunihiro, Shibuya, Hiroshi

“…The WNK1 and WNK4 genes have been found to be mutated in some patients with hyperkalemia and hypertension caused by pseudohypoaldosteronism type II. The clue…”
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Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model by Yang, Sung-Sen, Morimoto, Tetsuji, Rai, Tatemitsu, Chiga, Motoko, Sohara, Eisei, Ohno, Mayuko, Uchida, Keiko, Lin, Shih-Hua, Moriguchi, Tetsuo, Shibuya, Hiroshi, Kondo, Yoshiaki, Sasaki, Sei, Uchida, Shinichi

“…WNK1 and WNK4 mutations have been reported to cause pseudohypoaldosteronism type II (PHAII), an autosomal-dominant disorder characterized by hyperkalemia and…”
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A conserved docking motif in MAP kinases common to substrates, activators and regulators by Nishida, Eisuke, Tanoue, Takuji, Adachi, Makoto, Moriguchi, Tetsuo

“…Mitogen-activated protein kinases (MAPKs) are specifically phosphorylated and activated by the MAPK kinases, phosphorylate various targets such as…”
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JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates by Yamanaka, Hiroaki, Moriguchi, Tetsuo, Masuyama, Norihisa, Kusakabe, Morioh, Hanafusa, Hiroshi, Takada, Ritsuko, Takada, Shinji, Nishida, Eisuke

“…Recent genetic studies in Drosophila identified a novel non‐canonical Wnt pathway, the planar cell polarity (PCP) pathway, that signals via JNK to control…”
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Molecular Cloning and Characterization of a Novel Dual Specificity Phosphatase, MKP-5 by Tanoue, T, Moriguchi, T, Nishida, E

“…A group of dual specificity protein phosphatases negatively regulates members of the mitogen-activated protein kinase (MAPK) superfamily, which consists of…”
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Activation of the Protein Kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest by Takenaka, Katsuya, Moriguchi, Tetsuo, Nishida, Eisuke

“…The mitogen-activated protein kinase (MAPK) superfamily comprises classical MAPK (also called ERK), c-Jun amino-terminal or stress-activated protein kinase…”
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Ecrg4 contributes to the anti-glioma immunosurveillance through type-I interferon signaling by Moriguchi, Tetsuo, Kaneumi, Shun, Takeda, Shuji, Enomoto, Kei, Mishra, Shyam Kumar, Miki, Tetsuro, Koshimizu, Uichi, Kitamura, Hidemitsu, Kondo, Toru

“…Esophageal cancer-related gene 4 (Ecrg4), a hormone-like peptide, is thought to be a tumor suppressor, however, little is known about the mechanism of how…”
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Activation of Mitogen-Activated Protein Kinases after Transient Forebrain Ischemia in Gerbil Hippocampus by Sugino, Toshiyuki, Nozaki, Kazuhiko, Takagi, Yasushi, Hattori, Itaro, Hashimoto, Nobuo, Moriguchi, Tetsuo, Nishida, Eisuke

“…We investigated the expression, activation, and distribution of c-Jun N-terminal kinases (JNKs), p38 mitogen-activated protein kinases (p38s) and extracellular…”
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Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity by Hisamoto, Naoki, Moriguchi, Tetsuo, Urushiyama, Seiichi, Mitani, Shohei, Shibuya, Hiroshi, Matsumoto, Kunihiro

“…WNK kinases are a small group of unique serine/threonine protein kinases that are conserved among multicellular organisms. Mutations in WNK1–4 cause…”
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T Lymphocyte Activation Signals for Interleukin-2 Production Involve Activation of MKK6-p38 and MKK7-SAPK/JNK Signaling Pathways Sensitive to Cyclosporin A by Matsuda, Satoshi, Moriguchi, Tetsuo, Koyasu, Shigeo, Nishida, Eisuke

“…p38/CSBP, a subgroup member of mitogen-activated protein kinase (MAPK) superfamily molecules, is known to be activated by proinflammatory cytokines and…”
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Fas Induces Cytoplasmic Apoptotic Responses and Activation of the MKK7-JNK/SAPK and MKK6-p38 Pathways Independent of CPP32-like Proteases by Toyoshima, Fumiko, Moriguchi, Tetsuo, Nishida, Eisuke

“…IL-1β converting enzyme (ICE) family cysteine proteases are subdivided into three groups; ICE-, CPP32-, and Ich-1-like proteases. In Fas-induced apoptosis,…”
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TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase by Shirakabe, Kyoko, Yamaguchi, Kyoko, Shibuya, Hiroshi, Irie, Kenji, Matsuda, Satoshi, Moriguchi, Tetsuo, Gotoh, Yukiko, Matsumoto, Kunihiro, Nishida, Eisuke

“…Ceramide has been proposed as a second messenger molecule implicated in a variety of biological processes. It has recently been reported that ceramide…”
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A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3 by Moriguchi, Tetsuo, Kuroyanagi, Noriyo, Yamaguchi, Kyoko, Gotoh, Yukiko, Irie, Kenji, Kano, Takahisa, Shirakabe, Kyoko, Muro, Yoshinao, Shibuya, Hiroshi, Matsumoto, Kunihiro, Nishida, Eisuke, Hagiwara, Masatoshi

“…A cDNA encoding a novel member of the mitogen-activated protein kinase kinase (MAPKK) family, MAPKK6, was isolated and found to encode a protein of 334 amino…”
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DREG, a developmentally regulated G protein‐coupled receptor containing two conserved proteolytic cleavage sites by Moriguchi, Tetsuo, Haraguchi, Keiko, Ueda, Naoko, Okada, Masato, Furuya, Toshio, Akiyama, Tetsu

“…We have identified and characterized a novel member of the G protein‐coupled receptor (GPCR) family, termed DREG. DREG belongs to the LNB‐TM7 subfamily and…”
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Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates by Moriguchi, Tetsuo, Kawachi, Kaoru, Kamakura, Sachiko, Masuyama, Norihisa, Yamanaka, Hiroaki, Matsumoto, Kunihiro, Kikuchi, Akira, Nishida, Eisuke

“…Recent studies have shown thatDrosophila Dishevelled (Dsh), an essential component of thewingless signal transduction, is also involved in planar polarity…”
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Activation of Protein Kinase Cascades by Osmotic Shock (∗) by Matsuda, Satoshi, Kawasaki, Hiroshi, Moriguchi, Tetsuo, Gotoh, Yukiko, Nishida, Eisuke

“…Osmotic shock induces a variety of biochemical and physiological responses in vertebrate cells. By analyzing extracts obtained from rat 3Y1 fibroblastic cells…”
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Mixed Lineage Kinase LZK Forms a Functional Signaling Complex with JIP-1, a Scaffold Protein of the c-Jun NH2-Terminal Kinase Pathway by Ikeda, Atsushi, Hasegawa, Keiji, Masaki, Megumi, Moriguchi, Tetsuo, Nishida, Eisuke, Kozutsumi, Yasunori, Oka, Shogo, Kawasaki, Toshisuke

“…Leucine zipper-bearing kinase (LZK) is a novel member of the mixed lineage kinase (MLK) protein family, the cDNA of which was first cloned from a human brain…”
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LOK Is a Novel Mouse STE20-like Protein Kinase That Is Expressed Predominantly in Lymphocytes by Kuramochi, Satomi, Moriguchi, Tetsuo, Kuida, Keisuke, Endo, Junji, Semba, Kentaro, Nishida, Eisuke, Karasuyama, Hajime

“…We have identified a new gene, designatedlok (lymphocyte-oriented kinase), that encodes a 966-amino acid protein kinase whose catalytic domain at the N…”
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