Search Results - "Moriggl, R"

The role of Stat5 transcription factors as tumor suppressors or oncogenes by Ferbeyre, G., Moriggl, R.

“…Stat5 is constitutively activated in many human cancers affecting the expression of cell proliferation and cell survival controlling genes. These oncogenic…”
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Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression by Kramer, N, Schmöllerl, J, Unger, C, Nivarthi, H, Rudisch, A, Unterleuthner, D, Scherzer, M, Riedl, A, Artaker, M, Crncec, I, Lenhardt, D, Schwarz, T, Prieler, B, Han, X, Hengstschläger, M, Schüler, J, Eferl, R, Moriggl, R, Sommergruber, W, Dolznig, H

“…The canonical WNT signaling pathway is crucial for intestinal stem cell renewal and aberrant WNT signaling is an early event in colorectal cancer (CRC)…”
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Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL by Schrader, A., Crispatzu, G., Oberbeck, S., Mayer, P., Pützer, S., von Jan, J., Vasyutina, E., Warner, K., Weit, N., Pflug, N., Braun, T., Andersson, E. I., Yadav, B., Riabinska, A., Maurer, B., Ventura Ferreira, M. S., Beier, F., Altmüller, J., Lanasa, M., Herling, C. D., Haferlach, T., Stilgenbauer, S., Hopfinger, G., Peifer, M., Brümmendorf, T. H., Nürnberg, P., Elenitoba-Johnson, K. S. J., Zha, S., Hallek, M., Moriggl, R., Reinhardt, H. C., Stern, M.-H., Mustjoki, S., Newrzela, S., Frommolt, P., Herling, M.

“…T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in…”
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Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma by Gordziel, C, Bratsch, J, Moriggl, R, Knösel, T, Friedrich, K

“…Background: Aberrant activities of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signalling pathways have been implicated in the…”
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O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies by Freund, P, Kerenyi, M A, Hager, M, Wagner, T, Wingelhofer, B, Pham, H T T, Elabd, M, Han, X, Valent, P, Gouilleux, F, Sexl, V, Krämer, O H, Groner, B, Moriggl, R

“…The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells…”
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IGFBP7, a novel tumor stroma marker, with growth-promoting effects in colon cancer through a paracrine tumor–stroma interaction by Rupp, C, Scherzer, M, Rudisch, A, Unger, C, Haslinger, C, Schweifer, N, Artaker, M, Nivarthi, H, Moriggl, R, Hengstschläger, M, Kerjaschki, D, Sommergruber, W, Dolznig, H, Garin-Chesa, P

“…The activated tumor stroma participates in many processes that control tumorigenesis, including tumor cell growth, invasion and metastasis. Cancer-associated…”
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PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma by Garces de Los Fayos Alonso, I, Zujo, L, Wiest, I, Kodajova, P, Timelthaler, G, Edtmayer, S, Zrimšek, M, Kollmann, S, Giordano, C, Kothmayer, M, Neubauer, H A, Dey, S, Schlederer, M, Schmalzbauer, B S, Limberger, T, Probst, C, Pusch, O, Högler, S, Tangermann, S, Merkel, O, Schiefer, A I, Kornauth, C, Prutsch, N, Zimmerman, M, Abraham, B, Anagnostopoulos, J, Quintanilla-Martinez, L, Mathas, S, Wolf, P, Stoiber, D, Staber, P B, Egger, G, Klapper, W, Woessmann, W, Look, T A, Gunning, P, Turner, S D, Moriggl, R, Lagger, S, Kenner, L

“…Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin T cell lymphoma commonly driven by NPM-ALK. AP-1 transcription factors, cJUN and JUNb, act…”
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Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia by Eiring, A M, Page, B D G, Kraft, I L, Mason, C C, Vellore, N A, Resetca, D, Zabriskie, M S, Zhang, T Y, Khorashad, J S, Engar, A J, Reynolds, K R, Anderson, D J, Senina, A, Pomicter, A D, Arpin, C C, Ahmad, S, Heaton, W L, Tantravahi, S K, Todic, A, Colaguori, R, Moriggl, R, Wilson, D J, Baron, R, O'Hare, T, Gunning, P T, Deininger, M W

“…Mutations in the BCR-ABL1 kinase domain are an established mechanism of tyrosine kinase inhibitor (TKI) resistance in Philadelphia chromosome-positive…”
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Noncanonical effector functions of the T-memory–like T-PLL cell are shaped by cooperative TCL1A and TCR signaling by Oberbeck, S., Schrader, A., Warner, K., Jungherz, D., Crispatzu, G., von Jan, J., Chmielewski, M., Ianevski, A., Diebner, H.H., Mayer, P., Kondo Ados, A., Wahnschaffe, L., Braun, T., Müller, T.A., Wagle, P., Bouska, A., Neumann, T., Pützer, S., Varghese, L., Pflug, N., Thelen, M., Makalowski, J., Riet, N., Göx, H.J.M., Rappl, G., Altmüller, J., Kotrová, M., Persigehl, T., Hopfinger, G., Hansmann, M.L., Schlößer, H., Stilgenbauer, S., Dürig, J., Mougiakakos, D., von Bergwelt-Baildon, M., Roeder, I., Hartmann, S., Hallek, M., Moriggl, R., Brüggemann, M., Aittokallio, T., Iqbal, J., Newrzela, S., Abken, H., Herling, M.

“…T-cell prolymphocytic leukemia (T-PLL) is a poor-prognostic neoplasm. Differentiation stage and immune-effector functions of the underlying tumor cell are…”
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NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells by Jayavelu, A K, Müller, J P, Bauer, R, Böhmer, S-A, Lässig, J, Cerny-Reiterer, S, Sperr, W R, Valent, P, Maurer, B, Moriggl, R, Schröder, K, Shah, A M, Fischer, M, Scholl, S, Barth, J, Oellerich, T, Berg, T, Serve, H, Frey, S, Fischer, T, Heidel, F H, Böhmer, F-D

“…Activating mutations of FMS -like tyrosine kinase 3 (FLT3), notably internal tandem duplications (ITDs), are associated with a grave prognosis in acute myeloid…”
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Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR–ABL-positive cells by Chatain, N, Ziegler, P, Fahrenkamp, D, Jost, E, Moriggl, R, Schmitz-Van de Leur, H, Müller-Newen, G

“…Persistent activation of the Abl tyrosine kinase in the BCR–ABL fusion protein is the major cause of chronic myeloid leukemia (CML). Among many other…”
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PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis by Berger, A, Hoelbl-Kovacic, A, Bourgeais, J, Hoefling, L, Warsch, W, Grundschober, E, Uras, I Z, Menzl, I, Putz, E M, Hoermann, G, Schuster, C, Fajmann, S, Leitner, E, Kubicek, S, Moriggl, R, Gouilleux, F, Sexl, V

“…The transcription factor STAT5 (signal transducer and activator of transcription 5) is frequently activated in hematological malignancies and represents an…”
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Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells by Peter, B, Bibi, S, Eisenwort, G, Wingelhofer, B, Berger, D, Stefanzl, G, Blatt, K, Herrmann, H, Hadzijusufovic, E, Hoermann, G, Hoffmann, T, Schwaab, J, Jawhar, M, Willmann, M, Sperr, W R, Zuber, J, Sotlar, K, Horny, H-P, Moriggl, R, Reiter, A, Arock, M, Valent, P

“…Systemic mastocytosis (SM) is a mast cell (MC) neoplasm with complex pathology and a variable clinical course. In aggressive SM (ASM) and MC leukemia (MCL),…”
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Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation by Girardot, M, Pecquet, C, Chachoua, I, Van Hees, J, Guibert, S, Ferrant, A, Knoops, L, Baxter, E J, Beer, P A, Giraudier, S, Moriggl, R, Vainchenker, W, Green, A R, Constantinescu, S N

“…STAT (Signal Transducer and Activator of Transcription) transcription factors are constitutively activated in most hematopoietic cancers. We previously…”
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Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy by Bibi, Siham, Arslanhan, Melis Dilara, Langenfeld, Florent, Jeanningros, Sylvie, Cerny-Reiterer, Sabine, Hadzijusufovic, Emir, Tchertanov, Luba, Moriggl, Richard, Valent, Peter, Arock, Michel

“…Chronic myeloid leukemia and systemic mastocytosis are myeloid neoplasms sharing a number of pathogenetic and clinical features. In both conditions, an…”
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Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia by Eiring, A M, Page, B D G, Kraft, I L, Mason, C C, Vellore, N A, Resetca, D, Zabriskie, M S, Zhang, T Y, Khorashad, J S, Engar, A J, Reynolds, K R, Anderson, D J, Senina, A, Pomicter, A D, Arpin, C C, Ahmad, S, Heaton, W L, Tantravahi, S K, Todic, A, Colaguori, R, Moriggl, R, Wilson, D J, Baron, R, O'Hare, T, Gunning, P T, Deininger, M W

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Corrigendum to High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype12 [Translational Oncology Volume 12, Issue 2, February 2019, Pages 256-268] by Golob-Schwarzl, N., Bettermann, K., Mehta, A.K., Kessler, S.M., Unterluggauer, J., Krassnig, S., Kojima, K., Chen, X., Hoshida, Y., Bardeesy, N.M., Müller, H., Svendova, V., Schimek, M.G., Diwoky, C., Lipfert, A., Mahajan, V., Stumptner, C., Thüringer, A., Fröhlich, L.F., Stojakovic, T., Nilsson, K.P.R., Kolbe, T., Rülicke, T., Magin, T.M., Strnad, P., Kiemer, A.K., Moriggl, R., Haybaeck, Johannes

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Stat5 gene dosage in T cells modulates CD8+ T‐cell homeostasis and attenuates contact hypersensitivity response in mice by Nivarthi, H., Prchal‐Murphy, M., Swoboda, A., Hager, M., Schlederer, M., Kenner, L., Tuckermann, J., Sexl, V., Moriggl, R., Ermakova, O.

“…Background Contact hypersensitivity assay (CHS) faithfully models human allergies. The Stat5 transcription factors are essential for both lymphocyte…”
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New perspectives in stem cell research: beyond embryonic stem cells by Leeb, C., Jurga, M., McGuckin, C., Forraz, N., Thallinger, C., Moriggl, R., Kenner, L.

“…Although stem cell research is a rather new field in modern medicine, media soon popularized it. The reason for this hype lies in the potential of stem cells…”
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STAT5A/5B-specific expansion and transformation of hematopoietic stem cells by Ghanem, S, Friedbichler, K, Boudot, C, Bourgeais, J, Gouilleux-Gruart, V, Régnier, A, Herault, O, Moriggl, R, Gouilleux, F

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