Search Results - "Moriarty, Orla"

The effect of pain on cognitive function: a review of clinical and preclinical research by Moriarty, Orla, McGuire, Brian E, Finn, David P

“…Cognitive impairment is commonly associated with the pain experience. This impairment represents a major obstacle to daily activities and rehabilitation,…”
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Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats by Mapplebeck, Josiane C.S., Dalgarno, Rebecca, Tu, YuShan, Moriarty, Orla, Beggs, Simon, Kwok, Charlie H.T., Halievski, Katherine, Assi, Sofia, Mogil, Jeffrey S., Trang, Tuan, Salter, Michael W.

“…Microglia-neuron signalling in the spinal cord is a key mediator of mechanical allodynia caused by peripheral nerve injury. We recently reported sex…”
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Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats by Moriarty, Orla, Tu, YuShan, Sengar, Ameet S, Salter, Michael W, Beggs, Simon, Walker, Suellen M

“…Neonatal hindpaw incision primes developing spinal nociceptive circuitry, resulting in enhanced hyperalgesia following reinjury in adulthood. Spinal microglia…”
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Cognitive Impairment in Patients with Chronic Neuropathic or Radicular Pain: An Interaction of Pain and Age by Moriarty, Orla, Ruane, Nancy, O'Gorman, David, Maharaj, Chris H, Mitchell, Caroline, Sarma, Kiran M, Finn, David P, McGuire, Brian E

“…A growing body of empirical research has confirmed an association between chronic pain and cognitive dysfunction. The aim of the present study was to determine…”
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Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain by Moriarty, Orla, Roche, Michelle, McGuire, Brian E., Finn, David P.

“…► This article describes a novel air-puff-induced passive-avoidance paradigm in rats. ► We describe pharmacological validation of the paradigm using…”
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Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression by Burke, Nikita N, Kerr, Daniel M, Moriarty, Orla, Finn, David P, Roche, Michelle

“…Abstract There is a paucity of data on the role of microglia and neuroinflammatory processes in the association between chronic pain and depression. The…”
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Cognition and pain by Moriarty, Orla, Finn, David P.

“…PURPOSE OF REVIEWPain and cognition share common neural substrates and are known to interact reciprocally. This has implications for treatment and management…”
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A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain by Wang, Jiafu, Casals-Diaz, Laura, Zurawski, Tomas, Meng, Jianghui, Moriarty, Orla, Nealon, John, Edupuganti, Om Prakash, Dolly, Oliver

“…A pressing need exists for long-acting, non-addictive medicines to treat chronic pain, a major societal burden. Botulinum neurotoxin type A (BoNT/A) complex –…”
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Impaired cued and spatial learning performance and altered cannabinoid CB1 receptor functionality in the substantia nigra in a rat model of diabetic neuropathy by Moriarty, Orla, Lang, Yvonne, Idrees, Zubair, McGuire, Brian E., Finn, David P.

“…•STZ-treated rats developed mechanical allodynia and thermal hypoalgesia.•STZ-treated rats showed impaired cued and reference learning in the water maze.•CB1…”
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Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain by Bree, Dara, Moriarty, Orla, O'Mahony, Cliona M, Morris, Bradley, Bannerton, Karen, Broom, Daniel C, Kelly, John P, Roche, Michelle, Finn, David P

“…Acute postoperative pain remains a significant health care issue. Development of anatomically relevant animal models of postoperative pain, with improved…”
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Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain by Bree, Dara, Moriarty, Orla, Broom, Daniel C., Kelly, John P., Roche, Michelle, Finn, David P.

“…Summary Aims Acute postoperative pain remains a significant healthcare issue. Historically, the assessment of postoperative pain in rodents has relied on…”
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Impaired recognition memory and cognitive flexibility in the rat L5–L6 spinal nerve ligation model of neuropathic pain by Moriarty, Orla, Gorman, Claire L, McGowan, Fiona, Ford, Gemma K, Roche, Michelle, Thompson, Kerry, Dockery, Peter, McGuire, Brian E, Finn, David P

“…Highlights • L5–L6 spinal nerve ligation in rats was associated with allodynia and hyperalgesia. • Nerve-injured rats exhibited impaired recognition memory. •…”
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Investigating the effects of distracting stimuli on nociceptive behaviour and associated alterations in brain monoamines in rats by Ford, Gemma K, Moriarty, Orla, McGuire, Brian E, Finn, David P

“…Abstract Distraction interventions are used clinically to relieve pain. Exposure to distracting stimuli causes withdrawal of attention from the painful…”
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Impaired recognition memory and cognitive flexibility in the ratL5–L6 spinal nerve ligation model of neuropathic pain by Moriarty, Orla, Gorman, Claire L., McGowan, Fiona, Ford, Gemma K., Roche, Michelle, Thompson, Kerry, Dockery, Peter, McGuire, Brian E., Finn, David P.

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