Search Results - "Mori, Yasuo"

Ion channelopathies to bridge molecular lesions, channel function, and clinical therapies by Carbone, Emilio, Mori, Yasuo

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A molecular cell atlas of the human lung from single-cell RNA sequencing by Travaglini, Kyle J., Nabhan, Ahmad N., Penland, Lolita, Sinha, Rahul, Gillich, Astrid, Sit, Rene V., Chang, Stephen, Conley, Stephanie D., Mori, Yasuo, Seita, Jun, Berry, Gerald J., Shrager, Joseph B., Metzger, Ross J., Kuo, Christin S., Neff, Norma, Weissman, Irving L., Quake, Stephen R., Krasnow, Mark A.

“…Although single-cell RNA sequencing studies have begun to provide compendia of cell expression profiles 1 – 9 , it has been difficult to systematically…”
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TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells by Gershkovitz, Maya, Caspi, Yaki, Fainsod-Levi, Tanya, Katz, Ben, Michaeli, Janna, Khawaled, Saleh, Lev, Shaya, Polyansky, Lola, Shaul, Merav E, Sionov, Ronit V, Cohen-Daniel, Leonor, Aqeilan, Rami I, Shaul, Yoav D, Mori, Yasuo, Karni, Rotem, Fridlender, Zvi G, Binshtok, Alexander M, Granot, Zvi

“…Neutrophils play a critical role in cancer, with both protumor and antitumor neutrophil subpopulations reported. The antitumor neutrophil subpopulation has the…”
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Redox regulation of transient receptor potential channels by Kozai, Daisuke, Ogawa, Nozomi, Mori, Yasuo

“…Environmental and endogenous reactive species such as reactive oxygen species (ROS), reactive nitrogen species (RNS), and other electrophiles are not only…”
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Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance by Takahashi, Nobuaki, Chen, Hsing-Yu, Harris, Isaac S., Stover, Daniel G., Selfors, Laura M., Bronson, Roderick T., Deraedt, Thomas, Cichowski, Karen, Welm, Alana L., Mori, Yasuo, Mills, Gordon B., Brugge, Joan S.

“…Cancer cell survival is dependent on oxidative-stress defenses against reactive oxygen species (ROS) that accumulate during tumorigenesis. Here, we show a…”
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Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury by Zong, Pengyu, Feng, Jianlin, Yue, Zhichao, Li, Yunfeng, Wu, Gongxiong, Sun, Baonan, He, Yanlin, Miller, Barbara, Yu, Albert S., Su, Zhongping, Xie, Jia, Mori, Yasuo, Hao, Bing, Yue, Lixia

“…Excitotoxicity induced by NMDA receptor (NMDAR) activation is a major cause of neuronal death in ischemic stroke. However, past efforts of directly targeting…”
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Possible involvement of TRPM2 activation in 5-fluorouracil-induced myelosuppression in mice by Ishibashi, Masaaki, Ishii, Masakazu, Yamamoto, Shinichiro, Mori, Yasuo, Shimizu, Shunichi

“…Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-sensitive Ca2+-permeable channel. The activation of TRPM2 by H2O2 causes cell death in…”
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Vital but vulnerable: Human TRPV6 is a trade-off of powerful Ca2+ uptake and susceptibility to epithelial barrier dysfunction by Mori, Yasuo, Omori, Mizuki, Nakao, Akito

“…Robust Ca2+ absorption is controlled by the highly Ca2+-permeable channels TRPV5 and TRPV6 in the kidney and intestine of terrestrial vertebrates, to fulfill…”
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Validating subcellular thermal changes revealed by fluorescent thermosensors by Kiyonaka, Shigeki, Sakaguchi, Reiko, Hamachi, Itaru, Morii, Takashi, Yoshizaki, Takenao, Mori, Yasuo

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ROLE of exercise in maintaining the integrity of the neuromuscular junction by Nishimune, Hiroshi, Stanford, John A., Mori, Yasuo

“…ABSTRACT Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous…”
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Efficacy of prophylactic letermovir for cytomegalovirus reactivation in hematopoietic cell transplantation: a multicenter real-world data by Mori, Yasuo, Jinnouchi, Fumiaki, Takenaka, Katsuto, Aoki, Takatoshi, Kuriyama, Takuro, Kadowaki, Masanori, Odawara, Jun, Ueno, Toshiyuki, Kohno, Kentaro, Harada, Takuya, Yoshimoto, Goichi, Takase, Ken, Henzan, Hideho, Kato, Koji, Ito, Yoshikiyo, Kamimura, Tomohiko, Ohno, Yuju, Ogawa, Ryosuke, Eto, Tetsuya, Nagafuji, Koji, Akashi, Koichi, Miyamoto, Toshihiro

“…A novel anti-cytomegalovirus (CMV) agent, letermovir (LMV), could reportedly improve the outcomes of allogeneic hematopoietic cell transplantation (allo-HCT)…”
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Modulation of NMDAR subunit expression by TRPM2 channels regulates neuronal vulnerability to ischemic cell death by Alim, Ishraq, Teves, Lucy, Li, Rongwen, Mori, Yasuo, Tymianski, Michael

“…Neuronal vulnerability to ischemia is dependent on the balance between prosurvival and prodeath cellular signaling. In the latter, it is increasingly…”
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Thermosensitive Ion Channel Activation in Single Neuronal Cells by Using Surface-Engineered Plasmonic Nanoparticles by Nakatsuji, Hirotaka, Numata, Tomohiro, Morone, Nobuhiro, Kaneko, Shuji, Mori, Yasuo, Imahori, Hiroshi, Murakami, Tatsuya

“…Controlling cell functions using external photoresponsive nanomaterials has enormous potential for the development of cell‐engineering technologies and…”
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Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence by Nishimura, Akiyuki, Shimauchi, Tsukasa, Tanaka, Tomohiro, Shimoda, Kakeru, Toyama, Takashi, Kitajima, Naoyuki, Ishikawa, Tatsuya, Shindo, Naoya, Numaga-Tomita, Takuro, Yasuda, Satoshi, Sato, Yoji, Kuwahara, Koichiro, Kumagai, Yoshito, Akaike, Takaaki, Ide, Tomomi, Ojida, Akio, Mori, Yasuo, Nishida, Motohiro

“…Defective mitochondrial dynamics through aberrant interactions between mitochondria and actin cytoskeleton is increasingly recognized as a key determinant of…”
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Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells by Kiyonaka, Shigeki, Kajimoto, Taketoshi, Sakaguchi, Reiko, Shinmi, Daisuke, Omatsu-Kanbe, Mariko, Matsuura, Hiroshi, Imamura, Hiromi, Yoshizaki, Takenao, Hamachi, Itaru, Morii, Takashi, Mori, Yasuo

“…Genetically encoded sensors based on GFP enable the visualization of subcellular thermal changes noninvasively in intact cells. In mammals and birds,…”
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Determination of the physiological range of oxygen tension in bone marrow monocytes using two-photon phosphorescence lifetime imaging microscopy by Narazaki, Ayako, Shimizu, Reito, Yoshihara, Toshitada, Kikuta, Junichi, Sakaguchi, Reiko, Tobita, Seiji, Mori, Yasuo, Ishii, Masaru, Nishikawa, Keizo

“…Oxygen is a key regulator of both development and homeostasis. To study the role of oxygen, a variety of in vitro and ex vivo cell and tissue models have been…”
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Deletion of TRPC3 or TRPC6 Fails to Attenuate the Formation of Inflammation and Fibrosis in Non-alcoholic Steatohepatitis by Nishiyama, Kazuhiro, Toyama, Chiemi, Kato, Yuri, Tanaka, Tomohiro, Nishimura, Akiyuki, Nagata, Ryu, Mori, Yasuo, Nishida, Motohiro

“…Non-alcoholic steatohepatitis (NASH) is a disease that has progressed from non-alcoholic fatty liver disease (NAFLD) and is characterized by inflammation and…”
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Spironolactone Reduces Cardiovascular and Cerebrovascular Morbidity and Mortality in Hemodialysis Patients by Matsumoto, Yoshihiro, MD, Mori, Yasuo, MD, Kageyama, Shinji, MD, Arihara, Kazuo, MD, Sugiyama, Toshikazu, MD, Ohmura, Hiromichi, MD, Yakushigawa, Toru, MD, Sugiyama, Hatsumi, MD, Shimada, Yasushi, MD, Nojima, Youichi, MD, Shio, Nobuo, MD

“…Objectives This study sought to assess whether spironolactone treatment reduces the high incidence of cardiovascular and cerebrovascular (CCV) morbidity and…”
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In vitro and in vivo characterization of modulation of the vacuolar cation channel TRPY1 from Saccharomyces cerevisiae by Hamamoto, Shin, Mori, Yasuo, Yabe, Isamu, Uozumi, Nobuyuki

“…Saccharomyces cerevisiae possesses a transient receptor potential (TRP) channel homolog TRPY1 in its vacuolar membrane, considered to be an ancestral TRP…”
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Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia by Kikushige, Yoshikane, Ishikawa, Fumihiko, Miyamoto, Toshihiro, Shima, Takahiro, Urata, Shingo, Yoshimoto, Goichi, Mori, Yasuo, Iino, Tadafumi, Yamauchi, Takuji, Eto, Tetsuya, Niiro, Hiroaki, Iwasaki, Hiromi, Takenaka, Katsuto, Akashi, Koichi

“…We report here that in chronic lymphocytic leukemia (CLL), the propensity to generate clonal B cells has been acquired already at the hematopoietic stem cell…”
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