The interferon reaction of the leukocytes and the natural killer activity in patients with acute viral hepatitis B undergoing interferon treatment

The interferon response of leukocytes (IRL) alpha and gamma as well as the functional activity of natural killers (NK) were studied in patients with the verified diagnosis of acute viral hepatitis B (AVH-B) treated with leukinferon (a preparation of natural interferon-alpha and cytokines) and reafer...

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Bibliographic Details
Published in:	Voprosy virusologiĭ Vol. 39; no. 4; p. 177
Main Authors:	Golban, T D, Cheshik, S G, Kuznetsov, V P, Beliaev, D L, Grishchenko, S V, Morgunov, K M, Babaiants, A A, Polikushina, O E, Antonenko, S M
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-07-1994
Subjects:	Acute Disease Adjuvants, Immunologic - administration & dosage Convalescence Cytokines - administration & dosage Drug Combinations Hepatitis B - immunology Hepatitis B - therapy Humans Interferon Type I - administration & dosage Interferon-alpha - blood Interferon-alpha - drug effects Interferon-gamma - blood Interferon-gamma - drug effects Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Leukocytes - drug effects Leukocytes - immunology Recombinant Proteins Time Factors
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Summary:	The interferon response of leukocytes (IRL) alpha and gamma as well as the functional activity of natural killers (NK) were studied in patients with the verified diagnosis of acute viral hepatitis B (AVH-B) treated with leukinferon (a preparation of natural interferon-alpha and cytokines) and reaferon (recombinant alpha 2 interferon). The effect of therapy with LF and RF in patients with AVH-B manifested by an increase in the functional activity of NK up to complete normalization after termination of the course of therapy. In the group of patients treated with LF as a result of therapy IRL-alpha increased by the end of the treatment and in the convalescence period. The observed activation of NK and the IF-alpha system under the effect of IF preparations in patients with AVH-B correlated with enhanced elimination of HBsAg.
ISSN:	0507-4088